sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.698 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.695 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.690 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.682 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.674 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.668 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.659 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.658 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.650 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.644 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.641 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.625 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.614 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.612 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.611 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.609 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.594 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.584 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.583 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.580 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.556 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.536 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.533 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.530 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.520 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.512 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.508 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.507 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.500 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.497 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.493 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.493 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.491 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.491 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.490 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.490 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.489 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.487 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.486 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.483 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.482 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.481 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.478 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.478 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.476 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.475 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.474 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.474 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.473 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.472 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.472 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.469 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.469 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.466 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 3gob | HXX | DdmC | / | 0.462 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.462 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.460 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.459 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.458 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.458 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.457 | |
| 3wec | AUI | Cytochrome P450 | / | 0.457 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.456 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.455 | |
| 3eej | 53R | Uncharacterized protein | / | 0.455 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.454 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.454 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.451 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.451 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.451 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.451 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.451 | |
| 4egn | TWO | Cytochrome P450 | / | 0.450 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.449 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.449 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.448 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.448 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.447 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.447 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.446 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.446 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.445 | |
| 1dyh | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.443 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.443 | |
| 1dhi | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.442 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.442 | |
| 4bge | PYW | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 4fmx | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.442 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.441 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.441 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.441 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.441 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.441 |