scPDB - Distribution of Binding site Similarity values of 1b39 entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
1b39	ATP	Cyclin-dependent kinase 2	2.7.11.22

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
1b39	ATP	Cyclin-dependent kinase 2	2.7.11.22	1.000
1hck	ATP	Cyclin-dependent kinase 2	2.7.11.22	0.595
1b38	ATP	Cyclin-dependent kinase 2	2.7.11.22	0.571
3r1y	X76	Cyclin-dependent kinase 2	2.7.11.22	0.521
3r1s	X73	Cyclin-dependent kinase 2	2.7.11.22	0.513
1h0v	UN4	Cyclin-dependent kinase 2	2.7.11.22	0.509
1y91	CT9	Cyclin-dependent kinase 2	2.7.11.22	0.508
3ezr	EZR	Cyclin-dependent kinase 2	2.7.11.22	0.507
3pls	ANP	Macrophage-stimulating protein receptor	2.7.10.1	0.507
3lfq	A28	Cyclin-dependent kinase 2	2.7.11.22	0.506
3r7y	Z04	Cyclin-dependent kinase 2	2.7.11.22	0.505
2r3j	SCJ	Cyclin-dependent kinase 2	2.7.11.22	0.498
2a4l	RRC	Cyclin-dependent kinase 2	2.7.11.22	0.497
4ek8	16K	Cyclin-dependent kinase 2	2.7.11.22	0.494
1jst	ATP	Cyclin-dependent kinase 2	2.7.11.22	0.492
2w05	FRT	Cyclin-dependent kinase 2	2.7.11.22	0.491
1w8c	N69	Cyclin-dependent kinase 2	2.7.11.22	0.490
2c5y	MTW	Cyclin-dependent kinase 2	2.7.11.22	0.490
5cno	ANP	Epidermal growth factor receptor	2.7.10.1	0.490
3lfn	A27	Cyclin-dependent kinase 2	2.7.11.22	0.489
2r3o	2SC	Cyclin-dependent kinase 2	2.7.11.22	0.488
2vtq	LZA	Cyclin-dependent kinase 2	2.7.11.22	0.487
1e1x	NW1	Cyclin-dependent kinase 2	2.7.11.22	0.485
3r7i	X9I	Cyclin-dependent kinase 2	2.7.11.22	0.485
4fl2	ANP	Tyrosine-protein kinase SYK	2.7.10.2	0.481
2r3p	3SC	Cyclin-dependent kinase 2	2.7.11.22	0.480
1pxo	CK7	Cyclin-dependent kinase 2	2.7.11.22	0.479
3r73	X87	Cyclin-dependent kinase 2	2.7.11.22	0.479
5cnn	ANP	Epidermal growth factor receptor	2.7.10.1	0.479
2c6o	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.478
4fl3	ANP	Tyrosine-protein kinase SYK	2.7.10.2	0.478
3s2p	PMU	Cyclin-dependent kinase 2	2.7.11.22	0.476
1h1r	6CP	Cyclin-dependent kinase 2	2.7.11.22	0.474
2vth	LZ2	Cyclin-dependent kinase 2	2.7.11.22	0.473
1h0w	207	Cyclin-dependent kinase 2	2.7.11.22	0.471
2r3m	SCX	Cyclin-dependent kinase 2	2.7.11.22	0.471
1qmz	ATP	Cyclin-dependent kinase 2	2.7.11.22	0.469
2fvd	LIA	Cyclin-dependent kinase 2	2.7.11.22	0.468
2r3i	SCF	Cyclin-dependent kinase 2	2.7.11.22	0.468
3r7u	X96	Cyclin-dependent kinase 2	2.7.11.22	0.468
2c6i	DT1	Cyclin-dependent kinase 2	2.7.11.22	0.467
3nyn	SGV	G protein-coupled receptor kinase 6	2.7.11.16	0.467
2b52	D42	Cyclin-dependent kinase 2	2.7.11.22	0.466
2r64	740	Cyclin-dependent kinase 2	2.7.11.22	0.465
3r7v	Z02	Cyclin-dependent kinase 2	2.7.11.22	0.464
1j1c	ADP	Glycogen synthase kinase-3 beta	2.7.11.26	0.462
3ddp	RC8	Cyclin-dependent kinase 2	2.7.11.22	0.462
3lmg	ANP	Receptor tyrosine-protein kinase erbB-3	2.7.10.1	0.462
3r8v	Z62	Cyclin-dependent kinase 2	2.7.11.22	0.462
3sqq	99Z	Cyclin-dependent kinase 2	2.7.11.22	0.462
2duv	371	Cyclin-dependent kinase 2	2.7.11.22	0.461
1pxp	CK8	Cyclin-dependent kinase 2	2.7.11.22	0.459
3rm6	18Z	Cyclin-dependent kinase 2	2.7.11.22	0.458
1ke6	LS2	Cyclin-dependent kinase 2	2.7.11.22	0.457
1pxj	CK2	Cyclin-dependent kinase 2	2.7.11.22	0.457
2r3g	SC9	Cyclin-dependent kinase 2	2.7.11.22	0.457
5c03	AGS	Non-receptor tyrosine-protein kinase TYK2	2.7.10.2	0.457
3p23	ADP	Serine/threonine-protein kinase/endoribonuclease IRE1	2.7.11.1	0.456
2vz6	FEF	Calcium/calmodulin-dependent protein kinase type II subunit alpha	2.7.11.17	0.455
3ddq	RRC	Cyclin-dependent kinase 2	2.7.11.22	0.455
3qzh	X69	Cyclin-dependent kinase 2	2.7.11.22	0.455
3rm7	19Z	Cyclin-dependent kinase 2	2.7.11.22	0.455
2r3l	SCW	Cyclin-dependent kinase 2	2.7.11.22	0.454
3q4z	ANP	Serine/threonine-protein kinase PAK 1	2.7.11.1	0.454
3my5	RFZ	Cyclin-dependent kinase 2	2.7.11.22	0.453
3r8p	Z46	Cyclin-dependent kinase 2	2.7.11.22	0.453
3lfs	A07	Cyclin-dependent kinase 2	2.7.11.22	0.452
3qqh	X0A	Cyclin-dependent kinase 2	2.7.11.22	0.452
3qwj	X6A	Cyclin-dependent kinase 2	2.7.11.22	0.452
4jrn	ANP	Rhoptry kinase family protein	/	0.451
1gih	1PU	Cyclin-dependent kinase 2	2.7.11.22	0.450
1h1s	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.450
1j39	UPG	DNA beta-glucosyltransferase	/	0.449
2ozo	ANP	Tyrosine-protein kinase ZAP-70	2.7.10.2	0.449
3qrt	X14	Cyclin-dependent kinase 2	2.7.11.22	0.449
2b9f	ADP	Mitogen-activated protein kinase FUS3	2.7.11.24	0.448
1mru	AGS	Serine/threonine-protein kinase PknB	2.7.11.1	0.447
4riy	ANP	Receptor tyrosine-protein kinase erbB-3	2.7.10.1	0.447
2r3k	SCQ	Cyclin-dependent kinase 2	2.7.11.22	0.446
3qqf	X07	Cyclin-dependent kinase 2	2.7.11.22	0.446
4bco	T6Q	Cyclin-dependent kinase 2	2.7.11.22	0.446
1ke7	LS3	Cyclin-dependent kinase 2	2.7.11.22	0.445
1pye	PM1	Cyclin-dependent kinase 2	2.7.11.22	0.445
2iw8	4SP	Cyclin-dependent kinase 2	2.7.11.22	0.445
2phk	ATP	Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	2.7.11.19	0.445
2vtp	LZ9	Cyclin-dependent kinase 2	2.7.11.22	0.445
3qzi	X72	Cyclin-dependent kinase 2	2.7.11.22	0.445
4k2r	ANP	Tyrosine-protein kinase ZAP-70	2.7.10.2	0.445
3qql	X03	Cyclin-dependent kinase 2	2.7.11.22	0.444
4dee	ADP	Aurora kinase A	2.7.11.1	0.444
2r3r	6SC	Cyclin-dependent kinase 2	2.7.11.22	0.443
3pj8	404	Cyclin-dependent kinase 2	2.7.11.22	0.443
4cfn	JYM	Cyclin-dependent kinase 2	2.7.11.22	0.443
1p2a	5BN	Cyclin-dependent kinase 2	2.7.11.22	0.442
1ykr	628	Cyclin-dependent kinase 2	2.7.11.22	0.442
1zth	ADP	RIO-type serine/threonine-protein kinase Rio1	2.7.11.1	0.442
2b55	D31	Cyclin-dependent kinase 2	2.7.11.22	0.442
2c6l	DT4	Cyclin-dependent kinase 2	2.7.11.22	0.442
2jjx	ATP	Uridylate kinase	/	0.442
2xmy	CDK	Cyclin-dependent kinase 2	2.7.11.22	0.442
2y9q	ANP	Mitogen-activated protein kinase 1	2.7.11.24	0.442
3rah	O1Z	Cyclin-dependent kinase 2	2.7.11.22	0.442
3rak	03Z	Cyclin-dependent kinase 2	2.7.11.22	0.442
4bcp	T3C	Cyclin-dependent kinase 2	2.7.11.22	0.442
4lyn	1YG	Cyclin-dependent kinase 2	2.7.11.22	0.442
1g5s	I17	Cyclin-dependent kinase 2	2.7.11.22	0.441
2c69	CT8	Cyclin-dependent kinase 2	2.7.11.22	0.441
3bu5	ATP	Insulin receptor	2.7.10.1	0.441
3rpo	24Z	Cyclin-dependent kinase 2	2.7.11.22	0.441
4fkl	CK2	Cyclin-dependent kinase 2	2.7.11.22	0.441
3ezv	EZV	Cyclin-dependent kinase 2	2.7.11.22	0.440
3qx4	X4B	Cyclin-dependent kinase 2	2.7.11.22	0.440
3r6x	X84	Cyclin-dependent kinase 2	2.7.11.22	0.440
3sw7	19K	Cyclin-dependent kinase 2	2.7.11.22	0.440
4i3z	ADP	Cyclin-dependent kinase 2	2.7.11.22	0.440