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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5l7d CLR Smoothened homolog

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5l7d CLRSmoothened homolog / 1.233
1zhz ERGOxysterol-binding protein homolog 4 / 0.753
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1nmd ATPMajor actin / 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.744
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.744
2zs9 ADPPantothenate kinase 2.7.1.33 0.744
3cwq ADPParA family chromosome partitioning protein / 0.744
3f8p NADNADH oxidase/thioredoxin reductase / 0.744
3fzf ATPHeat shock cognate 71 kDa protein / 0.744
3u9d ATPActin, alpha skeletal muscle / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
4e5l DBHPolymerase acidic protein / 0.744
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.744
4c49 HCYCorticosteroid-binding globulin / 0.714
3up3 XCAaceDAF-12 / 0.691
2yja ESTEstrogen receptor / 0.690
1kdm DHTSex hormone-binding globulin / 0.689
5hyr ESTEstrogen receptor / 0.687
2qgt EEDEstrogen receptor / 0.686
3cas ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.682
3q95 ESLEstrogen receptor / 0.680
3uzz TES3-oxo-5-beta-steroid 4-dehydrogenase / 0.678
2ocf ESTEstrogen receptor / 0.666
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1yra GDPGPN-loop GTPase PAB0955 / 0.660
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2hs4 ACPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2puf GUNHTH-type transcriptional repressor PurR / 0.660
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.660
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.660
4cdg ADPBloom syndrome protein 3.6.4.12 0.660
4nxv GDPMitochondrial dynamics protein MID51 / 0.660
4nxx GDPMitochondrial dynamics protein MID51 / 0.660
4o3m ADPBloom syndrome protein 3.6.4.12 0.660
2b01 TUDPhospholipase A2, major isoenzyme 3.1.1.4 0.658
1zhy CLROxysterol-binding protein homolog 4 / 0.655
1ot7 CHCBile acid receptor / 0.652
2ft9 CHDFatty acid-binding protein 2, liver / 0.652