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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5cvf ATP Casein kinase II subunit alpha 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.877
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.787
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.787
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.786
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.763
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.751
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.745
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.738
2pml ANPUncharacterized protein / 0.734
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.732
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.732
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.732
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.731
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.729
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.722
1u54 ACPActivated CDC42 kinase 1 / 0.720
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.716
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.715
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.714
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.713
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.711
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.711
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.711
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.710
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.709
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.707
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.706
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.706
5drd ATPAurora kinase A 2.7.11.1 0.704
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.703
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.702
1pjk ANPCasein kinase II subunit alpha 2.7.11.1 0.701
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.701
2pun ACPMethylthioribose kinase 2.7.1.100 0.697
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.696
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.696
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.695
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.694
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.694
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.694
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.694
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.694
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.693
1ol6 ATPAurora kinase A 2.7.11.1 0.692
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.692
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.691
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.691
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.691
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.690
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.689
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.689
5ce3 ADPProtein kinase YopO / 0.689
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.687
3orp AGSSerine/threonine protein kinase / 0.687
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.687
2pup ADPMethylthioribose kinase 2.7.1.100 0.686
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.686
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.686
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.684
5dos ATPAurora kinase A 2.7.11.1 0.684
3lmh ADPMyosin heavy chain kinase A 2.7.11.7 0.683
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.683
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4utd ACPAurora kinase A 2.7.11.1 0.683
1m0w ANPGlutathione synthetase 6.3.2.3 0.682
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.682
5dnr ATPAurora kinase A 2.7.11.1 0.682
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
5dr2 ATPAurora kinase A 2.7.11.1 0.679
2pyw ADPMethylthioribose kinase 2.7.1.100 0.678
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.678
5eg3 ACPFibroblast growth factor receptor 2 / 0.678
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.677
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.677
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.676
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.676
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.676
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.675
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.674
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.674
1zy5 ANPeIF-2-alpha kinase GCN2 / 0.674
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.674
2zdg ADPD-alanine--D-alanine ligase / 0.674
3ork AGSSerine/threonine protein kinase / 0.674
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.674
2olc ADPMethylthioribose kinase 2.7.1.100 0.673
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.673
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.672
2pui ADPMethylthioribose kinase 2.7.1.100 0.672
2pul ACPMethylthioribose kinase 2.7.1.100 0.672
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.671
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.671
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.670
3c4z ADPRhodopsin kinase / 0.670
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.670
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.669
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.668
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.667
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.666
4o4e ATPKinase / 0.666
4ork GDPBifunctional AAC/APH 2.3.1 0.666
1ol5 ADPAurora kinase A 2.7.11.1 0.665
5iqh GNPBifunctional AAC/APH 2.3.1 0.665
4ock ANPN-acetylhexosamine 1-kinase 2.7.1.162 0.664
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.663
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.663
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.662
3q5i ANPProtein kinase, putative / 0.662
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.661
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.660
5iqa GNPBifunctional AAC/APH 2.3.1 0.660
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.659
5byl GCPBifunctional AAC/APH 2.3.1 0.659
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.658
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.658
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.658
1cm8 ANPMitogen-activated protein kinase 12 / 0.657
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.657
5iqf GDPBifunctional AAC/APH 2.3.1 0.657
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.656
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.656
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.656
5dt4 ATPAurora kinase A 2.7.11.1 0.655
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.654
5l8j ADPAurora kinase A 2.7.11.1 0.654
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.653
3c50 ADPRhodopsin kinase / 0.653
3ort AGSSerine/threonine protein kinase / 0.653
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.653
4q5h ANPProtein kinase OspG 2.7 0.653
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.653
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.652
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.652
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.652
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.651
3zxt ACPDeath-associated protein kinase 1 2.7.11.1 0.650
4c3r ACPAurora kinase A 2.7.11.1 0.650