Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4uxj TTP Thymidine kinase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4uxj TTPThymidine kinase / 0.769
2uz3 TTPThymidine kinase / 0.739
1e79 ATPATP synthase subunit alpha, mitochondrial / 0.689
1e79 ATPATP synthase subunit beta, mitochondrial 3.6.3.14 0.689
1xbt TTPThymidine kinase, cytosolic 2.7.1.21 0.689
3zia ATPATP synthase subunit alpha, mitochondrial / 0.687
2c96 ATPPsp operon transcriptional activator / 0.682
2uyi ADPKinesin-like protein KIF11 / 0.679
3dt4 GTPPhosphoenolpyruvate carboxykinase, cytosolic [GTP] 4.1.1.32 0.677
2dr3 ADPUPF0273 protein PH0284 / 0.675
2jj1 ADPATP synthase subunit alpha, mitochondrial / 0.672
2jj1 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.672
1e79 ADPATP synthase subunit alpha, mitochondrial / 0.671
1e79 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.671
3af0 GDPPantothenate kinase 2.7.1.33 0.671
1l2t ATPUncharacterized ABC transporter ATP-binding protein MJ0796 / 0.668
2x2r ADPKinesin-like protein KIF11 / 0.663
1gil GSPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.662
1xmv ADPProtein RecA / 0.662
2pg2 ADPKinesin-like protein KIF11 / 0.662
3l9h ADPKinesin-like protein KIF11 / 0.662
2xae ADPKinesin-like protein KIF11 / 0.661
3ews ADPATP-dependent RNA helicase DDX19B 3.6.4.13 0.661
4ol0 GTPGTP-binding nuclear protein Ran / 0.661
1eyn 2ANUDP-N-acetylglucosamine 1-carboxyvinyltransferase / 0.660
1gy3 ATPCyclin-dependent kinase 2 2.7.11.22 0.660
1kzj CB3Thymidylate synthase / 0.660
1sn5 T3Transthyretin / 0.660
1svl ADPLarge T antigen 3.6.4 0.660
1vrq FONSubunit alpha of sarocosine oxidase / 0.660
2pc4 ASP_TRP_ASNFructose-bisphosphate aldolase 4.1.2.13 0.660
2tsc CB3Thymidylate synthase / 0.660
2xf3 J01Uncharacterized protein / 0.660
2xvv 9DNSerum albumin / 0.660
3cz0 9ODPheromone-binding protein ASP1 / 0.660
3fo7 IMNPhospholipase A2 VRV-PL-VIIIa / 0.660
3nks ACJProtoporphyrinogen oxidase 1.3.3.4 0.660
4b6u M7GEukaryotic translation initiation factor 4E type 3 / 0.660
4c1f X8ZMetallo-beta-lactamase type 2 / 0.660
4dsb A8SAbscisic acid receptor PYL3 / 0.660
4eil CB3Bifunctional dihydrofolate reductase-thymidylate synthase 1.5.1.3 0.660
4iqq D16Thymidylate synthase / 0.660
4ivo ACJProtoporphyrinogen oxidase 1.3.3.4 0.660
4kla CHDFerrochelatase, mitochondrial 4.99.1.1 0.660
5dby NPSSerum albumin / 0.660
5jqb IBPEnvelope glycoprotein / 0.660
1q3h ANPCystic fibrosis transmembrane conductance regulator / 0.659
2fna ADPUncharacterized protein / 0.658
2jj2 ADPATP synthase subunit alpha, mitochondrial / 0.658
2jj2 ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.658
3cob ADPKinesin heavy chain-like protein / 0.658
4yer ADPAntibiotic ABC transporter, ATP-binding protein, putative / 0.658
1v8k ANPKinesin-like protein KIF2C / 0.657
2jiz ADPATP synthase subunit beta, mitochondrial 3.6.3.14 0.657
2p2l GDPRas-related C3 botulinum toxin substrate 1 / 0.657
4asu ADPATP synthase subunit alpha, mitochondrial / 0.657
4r43 GDPPhosphoenolpyruvate carboxykinase [GTP] / 0.657
1l8q ADPChromosomal replication initiator protein DnaA / 0.656
2whx ADPGenome polyprotein 3.4.21.91 0.656
3wyf GTPGTP-binding nuclear protein / 0.656
3wyg GTPGTP-binding nuclear protein GSP1/CNR1 / 0.656
4b7b ADPKinesin-like protein KIF11 / 0.656
4tla ADPCircadian clock protein kinase KaiC 2.7.11.1 0.656
1um8 ADPATP-dependent Clp protease ATP-binding subunit ClpX / 0.655
2zrj AGSProtein RecA / 0.655
1r0z ATPCystic fibrosis transmembrane conductance regulator / 0.654
1rml NTSFibroblast growth factor 1 / 0.653
1zcb GDPGuanine nucleotide-binding protein subunit alpha-13 / 0.653
1ytm ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.652
4xsg GSPTransforming protein RhoA / 0.652
1sxj AGSReplication factor C subunit 1 / 0.651
1xp8 AGSProtein RecA / 0.650
2fah GDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial 4.1.1.32 0.650
4pk4 ADPUnconventional myosin-VI / 0.650
4ymu ATPABC-type polar amino acid transport system, ATPase component / 0.650