sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Å
NMR
1998-05-21
| Name: | Fibroblast growth factor 1 |
|---|---|
| ID: | FGF1_HUMAN |
| AC: | P05230 |
| Organism: | Homo sapiens |
| Reign: | Eukaryota |
| TaxID: | 9606 |
| EC Number: | / |
| Chain Name: | Percentage of Residues within binding site |
|---|---|
| A | 100 % |
| B-Factor: | 0.000 |
|---|---|
| Number of residues: | 20 |
| Including | |
| Standard Amino Acids: | 20 |
| Non Standard Amino Acids: | 0 |
| Water Molecules: | 0 |
| Cofactors: | |
| Metals: | |
| Ligandability | Volume (Å3) |
|---|---|
| 0.536 | 300.375 |
| % Hydrophobic | % Polar |
|---|---|
| 50.56 | 49.44 |
| According to VolSite | |
| HET Code: | NTS |
|---|---|
| Formula: | C10H5O9S3 |
| Molecular weight: | 365.336 g/mol |
| DrugBank ID: | DB04409 |
| Buried Surface Area: | 50.03 % |
| Polar Surface area: | 196.73 Å2 |
| Number of | |
|---|---|
| H-Bond Acceptors: | 9 |
| H-Bond Donors: | 0 |
| Rings: | 2 |
| Aromatic rings: | 2 |
| Anionic atoms: | 3 |
| Cationic atoms: | 0 |
| Rule of Five Violation: | 0 |
| Rotatable Bonds: | 3 |
| X | Y | Z |
|---|---|---|
| 14.4729 | -3.21277 | -1.98014 |
Image generated by PoseView
Represent the protein/ligand binding mode, centered on the ligand
Dashed lines represents hydrogen bonds and metal interactions
Green residue labels for amino acids with hydrophobic contacts (green lines) to the ligand
| Ligand | Protein | Interaction | |||
|---|---|---|---|---|---|
| Atom | Atom | Residue | Distance (Å) | Angle (°) | Type |
| O13 | NZ | LYS- 127 | 3.77 | 0 | Ionic (Protein Cationic) |
| O33 | NZ | LYS- 127 | 3.48 | 0 | Ionic (Protein Cationic) |
| C2 | CG | LYS- 127 | 3.89 | 0 | Hydrophobic |
| C4 | CB | GLN- 141 | 3.22 | 0 | Hydrophobic |
| C10 | CB | GLN- 141 | 4.2 | 0 | Hydrophobic |
| C7 | CB | ALA- 143 | 4.07 | 0 | Hydrophobic |
| C10 | CB | ALA- 143 | 3.42 | 0 | Hydrophobic |
