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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4txi FAD [F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4txi FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.312
2bra FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.223
2bry FAD[F-actin]-methionine sulfoxide oxidase MICAL1 1.14.13 1.189
4a99 FADTetX family tetracycline inactivation enzyme / 0.803
2rgj FADFlavin-containing monooxygenase / 0.772
3s5w FADL-ornithine N(5)-monooxygenase / 0.762
1rp0 AHZThiamine thiazole synthase, chloroplastic / 0.745
1e1m FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.736
3ihg FADAklavinone 12-hydroxylase RdmE / 0.733
3k30 ADPHistamine dehydrogenase / 0.727
2eq6 FADDihydrolipoyl dehydrogenase / 0.725
2ym1 FADPhenylacetone monooxygenase 1.14.13.92 0.725
4ap3 FADSteroid monooxygenase / 0.717
3lzw FADFerredoxin--NADP reductase 2 1.18.1.2 0.714
2eq8 FADDihydrolipoyl dehydrogenase / 0.712
3cge FADCoenzyme A disulfide reductase / 0.712
3ada NADSubunit alpha of sarocosine oxidase / 0.711
4x4j FADPutative oxygenase / 0.711
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.709
3ad9 NADSubunit alpha of sarocosine oxidase / 0.706
3qfa FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.705
4b65 FADL-ornithine N(5)-monooxygenase / 0.705
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.705
5cku FADL-ornithine N(5)-monooxygenase / 0.705
3uoy FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.704
4b68 FADL-ornithine N(5)-monooxygenase / 0.703
4z24 FADPutative GMC-type oxidoreductase R135 1 0.702
3l8k ADPDihydrolipoamide dehydrogenase (PdhD-3) / 0.701
4aox FADSteroid monooxygenase / 0.701
1bwc FADGlutathione reductase, mitochondrial 1.8.1.7 0.698
4ap1 FADSteroid monooxygenase / 0.698
4yac NAIC alpha-dehydrogenase / 0.698
2nvk FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.697
3g5s FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.696
4dna FADProbable glutathione reductase / 0.694
4eqx FADCoenzyme A disulfide reductase / 0.693
4tm1 FDAKtzI / 0.693
1dnc FADGlutathione reductase, mitochondrial 1.8.1.7 0.692
2gv8 FADThiol-specific monooxygenase 1.14.13 0.692
1f3p FADFerredoxin reductase / 0.691
3sm8 FNKFAD-dependent catabolic D-arginine dehydrogenase DauA / 0.691
1ges FADGlutathione reductase 1.8.1.7 0.690
3lzx FADFerredoxin--NADP reductase 2 1.18.1.2 0.690
4bjz FADProbable salicylate monooxygenase / 0.690
2yqu FADDihydrolipoyl dehydrogenase / 0.689
3cgb FADCoenzyme A disulfide reductase / 0.689
1grb FADGlutathione reductase, mitochondrial 1.8.1.7 0.687
1ger FADGlutathione reductase 1.8.1.7 0.686
2c7g FADNADPH-ferredoxin reductase FprA 1.18.1.2 0.686
2qa2 FADPolyketide oxygenase CabE / 0.686
4gde FDAUDP-galactopyranose mutase / 0.686
2ylx FADPhenylacetone monooxygenase 1.14.13.92 0.684
4wx1 FDAUDP-galactopyranose mutase / 0.684
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.682
4usr FADMonooxygenase / 0.681
1gvh FADFlavohemoprotein / 0.680
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.680
3nt6 FADFAD-dependent pyridine nucleotide-disulphide oxidoreductase / 0.680
2cdu ADPNADH oxidase / 0.679
2ylr FADPhenylacetone monooxygenase 1.14.13.92 0.679
3icr FADCoenzyme A disulfide reductase / 0.677
4b69 FADL-ornithine N(5)-monooxygenase / 0.677
4nzh FADL-ornithine N(5)-monooxygenase / 0.677
2jib ADPOxalyl-CoA decarboxylase 4.1.1.8 0.676
2wba FADTrypanothione reductase 1.8.1.12 0.676
4bv6 FADApoptosis-inducing factor 1, mitochondrial 1.1.1 0.676
4tm3 FADKtzI / 0.676
1d4d FADFumarate reductase flavoprotein subunit 1.3.5.4 0.675
1gpe FADGlucose oxidase 1.1.3.4 0.675
3cgd FADCoenzyme A disulfide reductase / 0.675
3sqp FADGlutathione reductase, mitochondrial 1.8.1.7 0.675
4tlx FDAKtzI / 0.675
4tlz FADKtzI / 0.675
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.674
4la1 FADThioredoxin glutathione reductase / 0.674
4z26 FADPutative GMC-type oxidoreductase R135 1 0.674
1pdh FASp-hydroxybenzoate hydroxylase / 0.673
1z6l FADPolyamine oxidase FMS1 / 0.672
2fjb SFDAdenylylsulfate reductase, subunit A (AprA) / 0.672
3g5q FADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO / 0.672
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.672
3qvr FADGlucose oxidase 1.1.3.4 0.671
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.670
3ean FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.670
1e1k FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.669
1qo8 FADFumarate reductase flavoprotein subunit / 0.669
2r0c FADPutative FAD-monooxygenase / 0.669
4d04 FADPhenylacetone monooxygenase 1.14.13.92 0.669
4ykg FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.669
1geu FADGlutathione reductase 1.8.1.7 0.668
1h6v FADThioredoxin reductase 1, cytoplasmic 1.8.1.9 0.667
1xpq FADPolyamine oxidase FMS1 / 0.667
2fjd SFDAdenylylsulfate reductase, subunit A (AprA) / 0.667
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.667
4u8n FDAUDP-galactopyranose mutase / 0.666
1jeh FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.665
2gr1 FADFerredoxin reductase / 0.665
3gwf FADCyclohexanone monooxygenase / 0.665
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.665
2dki FAD3-hydroxybenzoate 4-monooxygenase 1.14.13.23 0.664
4b1b FADThioredoxin reductase 1.8.1.9 0.664
4gus FADLysine-specific histone demethylase 1B 1 0.664
5hsa FASAlcohol oxidase 1 1.1.3.13 0.664
2a87 FADThioredoxin reductase 1.8.1.9 0.663
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.663
3uox FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.663
4d03 FADPhenylacetone monooxygenase 1.14.13.92 0.663
1fec FADTrypanothione reductase 1.8.1.12 0.662
2x8g FADThioredoxin glutathione reductase / 0.662
2xvf FADPutative flavin-containing monooxygenase / 0.662
4cnk FADL-amino acid oxidase / 0.662
2yls FADPhenylacetone monooxygenase 1.14.13.92 0.661
3bg7 FADPyranose 2-oxidase / 0.660
1feb FADTrypanothione reductase 1.8.1.12 0.659
1fl2 FADAlkyl hydroperoxide reductase subunit F 1.8.1 0.659
1nhs FADNADH peroxidase 1.11.1.1 0.659
3fpz AHZThiamine thiazole synthase / 0.659
4em3 FADCoenzyme A disulfide reductase / 0.659
1joa FADNADH peroxidase 1.11.1.1 0.658
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.658
4opt FDAConserved Archaeal protein / 0.658
4u8m FDAUDP-galactopyranose mutase / 0.658
2rab FADGlutathione amide reductase / 0.656
2x8h FADThioredoxin glutathione reductase / 0.656
2ylt FADPhenylacetone monooxygenase 1.14.13.92 0.656
4c5o FADPutative monooxygenase / 0.656
4dsg FADUncharacterized protein / 0.656
4jq9 FADDihydrolipoyl dehydrogenase / 0.656
1e1l FADNADPH:adrenodoxin oxidoreductase, mitochondrial 1.18.1.6 0.655
2cul FADGidA-related protein / 0.655
2eq7 FADDihydrolipoyl dehydrogenase / 0.655
3ics FADCoenzyme A disulfide reductase / 0.655
1tyt FADTrypanothione reductase 1.8.1.12 0.654
1y56 ATPUncharacterized protein / 0.654
3gwd FADCyclohexanone monooxygenase / 0.654
3qvp FADGlucose oxidase 1.1.3.4 0.654
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.654
3e23 SAMUncharacterized protein / 0.653
3up5 FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase 1.14.13.160 0.653
4fwj FADLysine-specific histone demethylase 1B 1 0.653
1k4q FADGlutathione reductase, mitochondrial 1.8.1.7 0.652
3nlc FADUncharacterized protein / 0.652
1h7w FADDihydropyrimidine dehydrogenase [NADP(+)] 1.3.1.2 0.651
3bi5 FADPolyamine oxidase FMS1 / 0.651
3grs FADGlutathione reductase, mitochondrial 1.8.1.7 0.651
3ict FADCoenzyme A disulfide reductase / 0.651
4u8l FDAUDP-galactopyranose mutase / 0.651
2ylw FADPhenylacetone monooxygenase 1.14.13.92 0.650
3ish FADThioredoxin reductase 1.8.1.9 0.650
4j57 FADThioredoxin reductase 2 1.8.1.9 0.650