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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4pz2 NAD Aldehyde dehydrogenase 2-6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4pz2 NADAldehyde dehydrogenase 2-6 / 1.230
4i8p NADAminoaldehyde dehydrogenase 1 / 1.121
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.084
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.070
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.068
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.052
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 1.047
3b4w NADAldehyde dehydrogenase family protein / 1.033
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.026
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.024
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.023
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.991
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.988
4i8q NADPutative betaine aldehyde dehyrogenase / 0.973
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.973
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.951
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.947
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.946
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.936
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.924
2jg7 NADAntiquitin / 0.916
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.907
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.901
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.901
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.899
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.898
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.894
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.893
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.893
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.884
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.884
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.881
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.857
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.847
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.847
3haz NADBifunctional protein PutA / 0.819
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.817
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.817
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.810
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.809
4pxl NADAldehyde dehydrogenase3 / 0.803
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.796
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.791
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.790
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.788
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.780
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.778
3iwj NADAminoaldehyde dehydrogenase / 0.772
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.763
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.758
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.757
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.754
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.754
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.751
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.748
4i9b NADPutative betaine aldehyde dehyrogenase / 0.738
4nmj NAPAldehyde dehydrogenase / 0.736
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.734
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.733
4nmk NAPAldehyde dehydrogenase / 0.728
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.724
1bi9 NADRetinal dehydrogenase 2 / 0.723
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.722
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.717
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.712
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.707
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.707
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.706
4i3v NADAldehyde dehydrogenase (NAD+) / 0.706
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.703
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.701
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.696
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.694
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.691
4i3w NADAldehyde dehydrogenase (NAD+) / 0.691
4h73 NDPAldehyde dehydrogenase / 0.688
4c3s NADAldehyde Dehydrogenase / 0.687
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.686
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.684
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.677
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.675
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.674
5ez4 NADBetaine-aldehyde dehydrogenase / 0.674
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.671
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.667
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.662
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.657
2voj NADAlanine dehydrogenase 1.4.1.1 0.657
5dib NADBetaine-aldehyde dehydrogenase / 0.656
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.652