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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oa5 SAH O-methyltransferase family protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oa5 SAHO-methyltransferase family protein / 1.053
4ymg SAMPutative SAM-dependent O-methyltranferase / 0.866
3duw SAHO-methyltransferase, putative / 0.860
3u81 SAHCatechol O-methyltransferase 2.1.1.6 0.857
4pyn SAHCatechol O-methyltransferase 2.1.1.6 0.842
2zth SAMCatechol O-methyltransferase 2.1.1.6 0.809
4pyo SAHCatechol O-methyltransferase 2.1.1.6 0.803
3cbg SAHO-methyltransferase / 0.800
2hnk SAHSAM-dependent O-methyltransferase / 0.767
3ssm SAHMycinamicin VI 2''-O-methyltransferase / 0.764
5ccb SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.762
3sso SAHMycinamicin VI 2''-O-methyltransferase / 0.756
2pwy SAHtRNA (adenine(58)-N(1))-methyltransferase TrmI 2.1.1.220 0.752
2yvl SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.743
3orh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.736
3axs SFGtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.732
3tr6 SAHO-methyltransferase / 0.728
5ccx SAHtRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 2.1.1.220 0.725
4xvy SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.722
1p1c SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.721
3a26 MTAtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.721
5dxj SFGHistone-arginine methyltransferase CARM1 / 0.719
5dwq SFGHistone-arginine methyltransferase CARM1 / 0.717
3c3y SAHO-methyltransferase / 0.716
2y1x SAHHistone-arginine methyltransferase CARM1 / 0.714
3b3f SAHHistone-arginine methyltransferase CARM1 / 0.714
1i9g SAMtRNA (adenine(58)-N(1))-methyltransferase TrmI / 0.713
5cku FADL-ornithine N(5)-monooxygenase / 0.711
2br5 SAHCephalosporin hydroxylase CmcI / 0.709
3ou2 SAHSAM-dependent methyltransferase / 0.705
3g07 SAM7SK snRNA methylphosphate capping enzyme 2.1.1 0.704
3tos SAHCalS11 / 0.704
2yr4 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.702
3hvk 719Catechol O-methyltransferase 2.1.1.6 0.702
3ldf SAHUncharacterized protein / 0.702
4x7y SAHMycinamicin III 3''-O-methyltransferase 2.1.1.237 0.702
5k7w SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.702
5g3t FDAFlavin-dependent L-tryptophan oxidase VioA / 0.698
5dx1 SFGHistone-arginine methyltransferase CARM1 / 0.697
1l3i SAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating) / 0.695
4dmg SAMUncharacterized protein / 0.695
2yxl SFG450aa long hypothetical fmu protein / 0.693
3a25 SAMtRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase / 0.693
3lcc SAHThiocyanate methyltransferase 1 / 0.692
7mht SAHModification methylase HhaI 2.1.1.37 0.692
4blw SAHRibosomal RNA large subunit methyltransferase J / 0.691
2c7q SAHModification methylase HhaI 2.1.1.37 0.690
4a99 FADTetX family tetracycline inactivation enzyme / 0.690
4c03 SFGProtein arginine N-methyltransferase 6 / 0.690
4gf5 SAHCalS11 / 0.690
4krh SAMPhosphoethanolamine N-methyltransferase 2 / 0.690
4obw SAM2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial / 0.690
2gs9 SAHUncharacterized protein / 0.689
3axt SAMtRNA (guanine(26)-N(2)/guanine(27)-N(2))-dimethyltransferase / 0.686
2z6u SAHModification methylase HhaI 2.1.1.37 0.685
2cww SAHUncharacterized protein / 0.684
4gek GEKCarboxy-S-adenosyl-L-methionine synthase / 0.684
5fa5 MTAProtein arginine N-methyltransferase 5 / 0.684
1skm SAHModification methylase HhaI 2.1.1.37 0.683
3bwc SAMSpermidine synthase, putative / 0.682
5bp9 SAHPutative methyltransferase protein / 0.682
2px2 SAHGenome polyprotein 2.7.7.48 0.680
3mht SAHModification methylase HhaI 2.1.1.37 0.680
5k7u SAMN6-adenosine-methyltransferase 70 kDa subunit / 0.680
2cdu ADPNADH oxidase / 0.678
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.678
4o29 SAHProtein-L-isoaspartate O-methyltransferase / 0.678
2qa2 FADPolyketide oxygenase CabE / 0.676
4gbe SAHDNA adenine methylase 2.1.1.72 0.676
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.676
3s1s SAHRestriction endonuclease BpuSI / 0.675
5e9w SAHmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.675
3vyw SAMUncharacterized protein / 0.674
4eqs FADCoenzyme A disulfide reductase / 0.674
1bc5 SAHChemotaxis protein methyltransferase 2.1.1.80 0.673
1khh SAHGuanidinoacetate N-methyltransferase 2.1.1.2 0.671
4guv FADTetX family tetracycline inactivation enzyme / 0.671
1af7 SAHChemotaxis protein methyltransferase 2.1.1.80 0.670
2zcj SAHModification methylase HhaI 2.1.1.37 0.670
5f2k SAHUncharacterized protein / 0.669
4b64 FADL-ornithine N(5)-monooxygenase / 0.668
4wxx SAHDNA (cytosine-5)-methyltransferase 1 2.1.1.37 0.667
2eju SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.666
3lby SAHUncharacterized protein / 0.666
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.666
2bm9 SAMCephalosporin hydroxylase CmcI / 0.665
3epp SFGmRNA cap guanine-N7 methyltransferase 2.1.1.56 0.665
2qe6 SAMUncharacterized protein / 0.664
5d1n SAHUncharacterized protein / 0.664
3sgl SAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC / 0.663
4g6h NAIRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.663
5il2 SAHN6-adenosine-methyltransferase 70 kDa subunit / 0.663
2okc SAMProbable type I restriction enzyme BthVORF4518P M protein 2.1.1.72 0.662
2vdv SAMtRNA (guanine-N(7)-)-methyltransferase / 0.662
4blv SAMRibosomal RNA large subunit methyltransferase J / 0.662
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.661
2i9k SAHModification methylase HhaI 2.1.1.37 0.661
2ytz SAHtRNA (guanine(26)-N(2))-dimethyltransferase / 0.661
3h5n ATPMccB protein / 0.661
5dst SAHProtein arginine N-methyltransferase 8 2.1.1 0.661
3grv ADNProbable ribosomal RNA small subunit methyltransferase A / 0.660
4ax8 SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.660
1zmc NADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.659
3iv6 SAMUncharacterized protein / 0.658
3qow SAMHistone-lysine N-methyltransferase, H3 lysine-79 specific 2.1.1.43 0.657
4iwn GEKCarboxy-S-adenosyl-L-methionine synthase / 0.657
3v8v SAMRibosomal RNA large subunit methyltransferase K/L 2.1.1.173 0.656
3gry SAMProbable ribosomal RNA small subunit methyltransferase A / 0.655
2ji9 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.654
3oe4 610Catechol O-methyltransferase 2.1.1.6 0.654
1boo SAHModification methylase PvuII 2.1.1.113 0.652
1wg8 SAMRibosomal RNA small subunit methyltransferase H / 0.652
4c05 SAHProtein arginine N-methyltransferase 6 / 0.652
5e72 SAMN2, N2-dimethylguanosine tRNA methyltransferase / 0.651
1nbh SAMGlycine N-methyltransferase 2.1.1.20 0.650
3emd SFGMethyltransferase / 0.650
3k30 ADPHistamine dehydrogenase / 0.650