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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nmk NAP Aldehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nmk NAPAldehyde dehydrogenase / 0.968
4h73 NDPAldehyde dehydrogenase / 0.828
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.810
4nmj NAPAldehyde dehydrogenase / 0.805
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.804
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.776
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.761
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.749
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.748
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.747
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.747
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.746
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.746
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.734
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.729
4pz2 NADAldehyde dehydrogenase 2-6 / 0.728
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.724
3iwj NADAminoaldehyde dehydrogenase / 0.719
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.719
4i8q NADPutative betaine aldehyde dehyrogenase / 0.717
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.710
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.709
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.706
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.706
4i9b NADPutative betaine aldehyde dehyrogenase / 0.701
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.700
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.700
4f3x NADPutative aldehyde dehydrogenase / 0.700
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.698
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.697
4i3v NADAldehyde dehydrogenase (NAD+) / 0.697
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.695
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.692
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.691
3haz NADBifunctional protein PutA / 0.691
4i8p NADAminoaldehyde dehydrogenase 1 / 0.691
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.690
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.690
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.690
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.687
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4i3w NADAldehyde dehydrogenase (NAD+) / 0.685
2ilu NDPLactaldehyde dehydrogenase 1.2.1.22 0.682
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.681
5dib NADBetaine-aldehyde dehydrogenase / 0.674
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.672
3b4w NADAldehyde dehydrogenase family protein / 0.667
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.664
4ucu 8HCDNA ligase / 0.664
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.663
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.661
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.654
3qfs NAPNADPH--cytochrome P450 reductase / 0.650