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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ipe ANP TNF receptor-associated protein 1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4ipe ANPTNF receptor-associated protein 1 / 1.081
4ivg ANPTNF receptor-associated protein 1 / 0.866
4wud ANPDNA gyrase subunit B / 0.855
4wuc ANPDNA gyrase subunit B / 0.821
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.817
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.803
3zkb ANPDNA gyrase subunit B / 0.789
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.784
4xc0 ACPHeat shock cognate 90 kDa protein / 0.775
1nhh ANPDNA mismatch repair protein MutL / 0.762
2ior ADPChaperone protein HtpG / 0.760
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.757
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.749
4gqt ADPHeat shock protein 90 / 0.743
3zkd ANPDNA gyrase subunit B / 0.734
3t0z ATPHeat shock protein HSP 90-alpha / 0.729
4xcl AGSHeat shock cognate 90 kDa protein / 0.729
3h4l ANPDNA mismatch repair protein PMS1 / 0.726
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.725
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.724
4r1f ADPDNA topoisomerase 2-alpha 5.99.1.3 0.716
1s16 ANPDNA topoisomerase 4 subunit B / 0.714
3a0t ADPSensor histidine kinase / 0.713
3t2s AGSHeat shock protein HSP 90-alpha / 0.708
1yt0 ADPEndoplasmin / 0.703
1y4s ADPChaperone protein HtpG / 0.701
3t10 ACPHeat shock protein HSP 90-alpha / 0.698
4xcj ADPHeat shock cognate 90 kDa protein / 0.698
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.697
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.696
3t1k ANPHeat shock protein HSP 90-alpha / 0.695
3sl2 ATPSensor histidine kinase WalK / 0.689
1byq ADPHeat shock protein HSP 90-alpha / 0.687
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.687
2xk2 ADPHeat shock protein HSP 90-alpha / 0.686
1ei1 ANPDNA gyrase subunit B / 0.685
3kmw ATPIntegrin-linked protein kinase 2.7.11.1 0.679
2yef ANPHeat shock protein HSP 90-alpha / 0.678
2xcm ADPCytosolic heat shock protein 90 / 0.677
4prv ADPDNA gyrase subunit B / 0.677
2o1u ANPEndoplasmin / 0.676
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.675
3rep ATPIntegrin-linked protein kinase 2.7.11.1 0.675
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.668
2bu2 ATP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.666
3ied AN2HSP90 / 0.662
2o1v ADPEndoplasmin / 0.659
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.658
4zse ANPEpidermal growth factor receptor 2.7.10.1 0.654
1mb9 ATPCarboxyethyl-arginine beta-lactam-synthase 6.3.3.4 0.652
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.652
1amw ADPATP-dependent molecular chaperone HSP82 / 0.651
1xjk DGTVitamin B12-dependent ribonucleotide reductase / 0.650