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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4idg NAD Putative UDP-glucose 4-epimerase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4idg NADPutative UDP-glucose 4-epimerase / 1.219
4id9 NADPutative UDP-glucose 4-epimerase / 1.020
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.822
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.811
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.806
3icp NADNAD-dependent epimerase/dehydratase / 0.804
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.803
4m55 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.792
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.783
4lk3 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.782
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.773
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.768
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.764
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 0.761
1zem NADXylitol dehydrogenase / 0.760
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.760
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.759
4cr8 NADN-acylmannosamine 1-dehydrogenase 1.1.1.233 0.756
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.752
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.751
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.751
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.750
2c29 NAPDihydroflavonol 4-reductase / 0.749
4hxy NDPPlm1 / 0.749
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.748
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.747
3ko8 NADNAD-dependent epimerase/dehydratase / 0.745
1i3l NADUDP-glucose 4-epimerase / 0.744
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.743
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.742
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.742
2z1m NDPGDP-mannose 4,6-dehydratase / 0.741
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.741
3mje NDPAmphB / 0.740
1rpn NDPGDP-mannose 4,6-dehydratase / 0.738
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.734
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.734
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.733
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.733
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.731
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.730
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.726
2z95 NDPGDP-mannose 4,6-dehydratase / 0.725
4qec NAPElxO / 0.725
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.724
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.723
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.722
3wds NADNADH-dependent quinuclidinone reductase / 0.722
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.721
3rfx NADUronate dehydrogenase / 0.720
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.719
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.717
4wec NADShort chain dehydrogenase / 0.717
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.716
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.716
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.715
4clo NAPPteridine reductase / 0.715
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.715
5d2e NAPMlnE / 0.714
1x7g NAPPutative ketoacyl reductase 1.3.1 0.713
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.713
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.713
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.711
3aw9 NADNAD-dependent epimerase/dehydratase / 0.711
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.710
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.709
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.709
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.708
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.707
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.707
2yy7 NADL-threonine dehydrogenase / 0.706
3wmx NADNAD dependent epimerase/dehydratase / 0.706
3h4v NAPPteridine reductase 1 1.5.1.33 0.705
4j7u NAPSepiapterin reductase 1.1.1.153 0.705
4u7w NDPMxaA / 0.705
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.704
3bmo NAPPteridine reductase / 0.704
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.704
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.701
1emd NADMalate dehydrogenase / 0.700
2wsb NADGalactitol dehydrogenase / 0.699
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.699
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.699
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.696
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.696
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.695
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.695
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.695
5jla NADPutative short-chain dehydrogenase/reductase / 0.693
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.692
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.692
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.692
5lc1 NADL-threonine 3-dehydrogenase / 0.692
1x7h NDPPutative ketoacyl reductase 1.3.1 0.691
4ros APRMalate dehydrogenase / 0.690
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.689
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.688
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.688
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.688
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.687
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.686
1oaa NAPSepiapterin reductase 1.1.1.153 0.686
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.685
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.684
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.683
2x0i NAIMalate dehydrogenase / 0.683
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.682
2dte NAIGlucose 1-dehydrogenase related protein / 0.682
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.681
4b79 NADProbable short-chain dehydrogenase / 0.680
2pk3 A2RGDP-6-deoxy-D-mannose reductase / 0.679
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.677
1sby NADAlcohol dehydrogenase 1.1.1.1 0.677
2p5u NADUDP-glucose 4-epimerase / 0.677
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.675
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.674
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.674
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.674
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.673
3ak4 NADNADH-dependent quinuclidinone reductase / 0.673
3ec7 NADInositol 2-dehydrogenase / 0.673
1ae1 NAPTropinone reductase 1 / 0.672
1ie3 NADMalate dehydrogenase / 0.671
2p5y NADUDP-glucose 4-epimerase / 0.671
3uce NDPDehydrogenase / 0.671
1wvg APRCDP-glucose 4,6-dehydratase 4.2.1.45 0.670
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.669
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.669
1pr9 NAPL-xylulose reductase 1.1.1.10 0.669
3o26 NDPSalutaridine reductase / 0.669
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.669
1z7e ATPBifunctional polymyxin resistance protein ArnA / 0.668
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.668
3a4v NADNDP-sugar epimerase / 0.667
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.667
5jyd NADShort chain dehydrogenase / 0.667
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.666
2wdz NADGalactitol dehydrogenase / 0.665
3geg NADShort-chain dehydrogenase/reductase SDR / 0.665
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.665
2yut NAPPutative short-chain oxidoreductase / 0.664
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.664
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.663
1dhr NADDihydropteridine reductase 1.5.1.34 0.662
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.662
2bfo NDPPteridine reductase 1 1.5.1.33 0.662
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.662
3sju NDPKeto reductase / 0.662
3sx2 NADUncharacterized protein / 0.662
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.662
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.662
5a02 NAPGlucose-fructose oxidoreductase / 0.662
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.661
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.661
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.661
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.661
1orr NADCDP-paratose 2-epimerase / 0.660
1sny NAPLD36273p / 0.660
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.660
4dbz NDPPutative ketoacyl reductase 1.3.1 0.660
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.659
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.658
3tn7 NJPShort-chain alcohol dehydrogenase / 0.658
4e5y NDPGDP-L-fucose synthase 1.1.1.271 0.658
4kwh NAPReductase homolog / 0.658
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.658
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.657
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.657
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.656
1qyx NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.655
3a9w NADNDP-sugar epimerase / 0.654
1xq6 NAPUncharacterized protein At5g02240 / 0.653
3d3w NAPL-xylulose reductase 1.1.1.10 0.653
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.653
4gf5 SAHCalS11 / 0.653
4yr9 NADL-threonine 3-dehydrogenase, mitochondrial 1.1.1.103 0.653
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.652
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.651
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.651
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.650
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.650
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.650
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.650
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.650