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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fw8 NAI 3-oxoacyl-(Acyl-carrier-protein) reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4fw8 NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 1.015
2dte NAIGlucose 1-dehydrogenase related protein / 0.782
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.753
1x7h NDPPutative ketoacyl reductase 1.3.1 0.747
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.741
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.739
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.738
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.733
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.731
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.729
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.725
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.724
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.722
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.721
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.720
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.720
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.719
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.718
3qrw NDPPutative ketoacyl reductase 1.3.1 0.718
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.717
1x7g NAPPutative ketoacyl reductase 1.3.1 0.716
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.715
3g49 NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.715
4wec NADShort chain dehydrogenase / 0.715
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.714
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.708
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.707
3ai2 NDPNADPH-sorbose reductase / 0.707
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.707
3tn7 NJPShort-chain alcohol dehydrogenase / 0.704
1orr NADCDP-paratose 2-epimerase / 0.703
4dbz NDPPutative ketoacyl reductase 1.3.1 0.702
2wsb NADGalactitol dehydrogenase / 0.701
3l77 NJPShort-chain alcohol dehydrogenase / 0.701
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.700
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.700
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.699
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.699
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.699
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.698
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.697
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.697
3ak4 NADNADH-dependent quinuclidinone reductase / 0.697
4bmv NAPShort-chain dehydrogenase / 0.697
1ipe NDPTropinone reductase 2 1.1.1.236 0.695
1pr9 NAPL-xylulose reductase 1.1.1.10 0.695
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.695
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.693
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.692
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.692
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.692
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.692
4yai NAIC alpha-dehydrogenase / 0.689
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.687
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.687
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.686
1ae1 NAPTropinone reductase 1 / 0.684
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.682
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.682
3o26 NDPSalutaridine reductase / 0.681
3sx2 NADUncharacterized protein / 0.681
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.680
3a1n NADNDP-sugar epimerase / 0.680
4yag NAIC alpha-dehydrogenase / 0.680
4kwh NAPReductase homolog / 0.677
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.676
3ai3 NDPNADPH-sorbose reductase / 0.676
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.676
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.676
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.676
1iy8 NADLevodione reductase / 0.675
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.674
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.674
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.673
3geg NADShort-chain dehydrogenase/reductase SDR / 0.673
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.671
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.670
1i3l NADUDP-glucose 4-epimerase / 0.669
3wds NADNADH-dependent quinuclidinone reductase / 0.669
1xkq NDPUncharacterized protein / 0.667
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.667
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.667
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.667
3d3w NAPL-xylulose reductase 1.1.1.10 0.666
4j7u NAPSepiapterin reductase 1.1.1.153 0.664
5jla NADPutative short-chain dehydrogenase/reductase / 0.664
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.663
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.662
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.660
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.660
3tsc NADUncharacterized protein / 0.660
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.660
3u4c NDPNADPH-dependent reductase BacG / 0.659
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.658
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.658
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.655
2p5u NADUDP-glucose 4-epimerase / 0.655
4b79 NADProbable short-chain dehydrogenase / 0.655
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.655
1g1a NADdTDP-glucose 4,6-dehydratase / 0.654
1w4z NAPPutative ketoacyl reductase 1.3.1 0.654
3s55 NADPutative short-chain dehydrogenase/reductase / 0.654
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.654
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.653
2bgl NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.653
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.653
2jah NDPClavaldehyde dehydrogenase / 0.652
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.652
1ek5 NADUDP-glucose 4-epimerase / 0.651
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.651
2hsd NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.651
3lqf NADGalactitol dehydrogenase / 0.651
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.650