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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4dh7 ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.279
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.239
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.220
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.203
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.202
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.200
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.185
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.179
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.177
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.161
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.148
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.113
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.075
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.024
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.009
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.992
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.990
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.984
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.982
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.981
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.976
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.970
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.949
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.921
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.914
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.897
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.885
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.883
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.882
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.877
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.867
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.837
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.808
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.793
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.787
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.786
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.785
4ysj ADPCalmodulin-like domain protein kinase / 0.784
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.782
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.774
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.774
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.771
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.770
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.769
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.765
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.761
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.758
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.758
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.755
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.755
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.753
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.753
1m0w ANPGlutathione synthetase 6.3.2.3 0.752
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.748
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.745
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.744
3ori AGSSerine/threonine protein kinase / 0.742
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.741
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.741
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.740
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.740
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.739
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.738
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.737
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.735
4qny ANPMitogen activated protein kinase, putative / 0.735
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.734
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.734
2pml ANPUncharacterized protein / 0.733
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.733
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.733
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.732
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.732
4ork GDPBifunctional AAC/APH 2.3.1 0.729
5ce3 ADPProtein kinase YopO / 0.727
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.725
1mq4 ADPAurora kinase A 2.7.11.1 0.724
2pup ADPMethylthioribose kinase 2.7.1.100 0.724
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
4dee ADPAurora kinase A 2.7.11.1 0.724
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.722
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.721
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.721
4ceg ADPAurora kinase A 2.7.11.1 0.721
4bn1 ADPAurora kinase A 2.7.11.1 0.719
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.719
3c4z ADPRhodopsin kinase / 0.718
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.716
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.716
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.715
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.714
5dn3 ATPAurora kinase A 2.7.11.1 0.714
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.713
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.712
4n57 ADPAPH(2'')-Id / 0.712
3wnz ADPAlanine--anticapsin ligase / 0.711
3c50 ADPRhodopsin kinase / 0.710
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.710
4o4d ATPKinase / 0.710
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.709
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.709
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.709
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.709
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.709
5dr2 ATPAurora kinase A 2.7.11.1 0.709
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.708
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.708
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.707
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.706
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.705
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.703
5iqa GNPBifunctional AAC/APH 2.3.1 0.702
3c4w ATPRhodopsin kinase / 0.701
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.701
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.700
3tdw GDPGentamicin resistance protein / 0.699
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.699
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.699
3qc9 ADPRhodopsin kinase / 0.698
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.697
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.696
5iqf GDPBifunctional AAC/APH 2.3.1 0.696
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.695
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.695
2pyw ADPMethylthioribose kinase 2.7.1.100 0.694
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.694
3orm AGSSerine/threonine protein kinase / 0.694
5iqb GNPBifunctional AAC/APH 2.3.1 0.694
3nie ANPMitogen-activated protein kinase / 0.693
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.692
2x86 ADPADP-L-glycero-D-manno-heptose-6-epimerase / 0.691
3tdv GDPGentamicin resistance protein / 0.691
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.690
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.690
3t8o ATPRhodopsin kinase / 0.689
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.689
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.688
2pul ACPMethylthioribose kinase 2.7.1.100 0.688
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.688
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.686
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.685
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.684
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.683
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.682
3iew CDP2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase / 0.682
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.681
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.681
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.681
5dt3 ATPAurora kinase A 2.7.11.1 0.681
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.680
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.680
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.680
2pui ADPMethylthioribose kinase 2.7.1.100 0.679
2py3 ACPFibroblast growth factor receptor 2 / 0.679
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.679
5drd ATPAurora kinase A 2.7.11.1 0.679
2pun ACPMethylthioribose kinase 2.7.1.100 0.678
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.677
1pk8 ATPSynapsin-1 / 0.677
3tw6 ADPPyruvate carboxylase / 0.677
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.676
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.675
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.674
4xlv ACPInsulin receptor 2.7.10.1 0.674
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.673
4utd ACPAurora kinase A 2.7.11.1 0.673
3llt ANPProtein serine/threonine kinase-1 / 0.672
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
4h5e YS4Farnesyl pyrophosphate synthase 2.5.1.10 0.672
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.672
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.671
4o0w ADNAurora kinase A 2.7.11.1 0.671
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.669
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.669
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.668
5byl GCPBifunctional AAC/APH 2.3.1 0.668
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.667
5dos ATPAurora kinase A 2.7.11.1 0.667
2x0q ATPAlcaligin biosynthesis protein / 0.666
2qdx FADFerredoxin--NADP+ reductase / 0.665
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.664
3crz FADFerredoxin--NADP+ reductase / 0.664
3wo0 ADPAlanine--anticapsin ligase / 0.664
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.664
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.663
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
1cm8 ANPMitogen-activated protein kinase 12 / 0.662
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.662
4ffr ATPUncharacterized protein / 0.662
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.661
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.661
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.660
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.660
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
2opm NI9Farnesyl pyrophosphate synthase 2.5.1.10 0.659
2pzp ACPFibroblast growth factor receptor 2 / 0.658
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.657
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.657
2w02 ATPAcsD / 0.657
4gyi ADPUncharacterized protein / 0.656
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.656
5iqh GNPBifunctional AAC/APH 2.3.1 0.656
2uvy GVIcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
5ce3 ATPActin / 0.655
1t44 ATPActin, alpha skeletal muscle / 0.654
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.654
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.654
3w3d ATPActin, gamma-enteric smooth muscle / 0.654
4uhr NGIAdenosine receptor A2a / 0.654
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.653
3ll9 ADPIsopentenyl phosphate kinase / 0.653
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.653
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.652
2jj2 ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.651
3dyh 721Farnesyl pyrophosphate synthase / 0.651
3wow ANPCasein kinase II subunit alpha 2.7.11.1 0.651
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.651
2dwb ANPAurora kinase A 2.7.11.1 0.650
2p6i SAHDiphthine synthase / 0.650
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.650
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.650
4jrn ANPRhoptry kinase family protein / 0.650
4o0u ADNAurora kinase A 2.7.11.1 0.650
4wud ANPDNA gyrase subunit B / 0.650