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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4cpd NAD Alcohol dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4cpd NADAlcohol dehydrogenase / 1.197
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.856
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.843
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.838
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.836
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.833
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.825
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.825
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.822
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.820
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.819
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.819
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.816
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.816
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.814
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.813
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.811
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.810
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.809
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.809
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.809
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.809
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.809
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.806
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.806
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.802
2dph NADFormaldehyde dismutase / 0.801
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.797
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.796
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.795
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.794
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.792
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.791
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.786
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.786
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.784
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.780
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.778
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.776
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.774
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.768
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.766
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.765
4oaq NDPR-specific carbonyl reductase / 0.760
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.760
4l0q NADAlcohol dehydrogenase class-3 / 0.755
2d8a NADL-threonine 3-dehydrogenase / 0.752
3wle NAD(R)-specific carbonyl reductase / 0.752
1yqd NAPSinapyl alcohol dehydrogenase / 0.750
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.748
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.745
3jv7 NADSecondary alcohol dehydrogenase / 0.744
4c4o NADSADH / 0.742
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.739
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.738
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.737
4rqu NADAlcohol dehydrogenase class-P / 0.736
4ejm NAPPutative zinc-binding dehydrogenase / 0.730
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.728
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.727
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.720
4jji NADAlcohol dehydrogenase class-3 / 0.720
1u7h NADPutative ornithine cyclodeaminase / 0.719
4gl4 NAIAlcohol dehydrogenase class-3 / 0.718
4j43 NADUncharacterized protein / 0.715
1x7d NADPutative ornithine cyclodeaminase / 0.712
3oet NADErythronate-4-phosphate dehydrogenase / 0.712
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.712
3wsw NADL-lactate dehydrogenase / 0.710
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.709
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.709
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.708
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.707
4j49 NADUncharacterized protein / 0.706
1ib6 NADMalate dehydrogenase / 0.703
2o4c NADErythronate-4-phosphate dehydrogenase / 0.703
4j4b NAIUncharacterized protein / 0.698
2x0r NADMalate dehydrogenase / 0.695
2x0i NAIMalate dehydrogenase / 0.694
4jk3 NADUncharacterized protein / 0.694
1gv0 NADMalate dehydrogenase / 0.692
1ie3 NADMalate dehydrogenase / 0.688
2cda NAPGlucose 1-dehydrogenase / 0.688
2dfv NADL-threonine 3-dehydrogenase / 0.686
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.684
1f8f NADBenzyl alcohol dehydrogenase / 0.682
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.682
1o6z NADMalate dehydrogenase / 0.681
1uxk NADMalate dehydrogenase / 0.681
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.680
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.679
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.679
2xaa NADSecondary alcohol dehydrogenase / 0.676
2a92 NAIL-lactate dehydrogenase / 0.675
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.675
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.675
1pzh NADLactate dehydrogenase / 0.674
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.674
2ome NADC-terminal-binding protein 2 / 0.672
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.671
4uun NAIL-lactate dehydrogenase / 0.671
3uko NADAlcohol dehydrogenase class-3 / 0.670
2uyy NA7Putative oxidoreductase GLYR1 1 0.669
1bdm NAXMalate dehydrogenase / 0.667
1uxj NADMalate dehydrogenase / 0.667
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.667
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.667
4i1i NADMalate dehydrogenase / 0.667
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.666
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.666
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.665
4plp NADHomospermidine synthase 2.5.1.44 0.664
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.663
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.663
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.662
3abi NADUncharacterized protein / 0.662
3d64 NADAdenosylhomocysteinase / 0.662
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.662
2ejv NADL-threonine 3-dehydrogenase / 0.661
4xq9 NADHomospermidine synthase 2.5.1.44 0.661
4xqc NADHomospermidine synthase 2.5.1.44 0.661
2voj NADAlanine dehydrogenase 1.4.1.1 0.660
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.659
3kb6 NADD-lactate dehydrogenase / 0.659
1bmd NADMalate dehydrogenase / 0.658
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.658
1pzf A3DLactate dehydrogenase / 0.657
1pzg A3DLactate dehydrogenase / 0.657
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.657
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.657
1llu NADAlcohol dehydrogenase / 0.656
2vhx NADAlanine dehydrogenase 1.4.1.1 0.656
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.655
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.655
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.655
2cdc NAPGlucose 1-dehydrogenase / 0.654
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.654
4xrg NADHomospermidine synthase 2.5.1.44 0.653
3x2e NAIAdenosylhomocysteinase / 0.652
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.651
1pjc NADAlanine dehydrogenase / 0.651
2aa3 AP0L-lactate dehydrogenase / 0.651
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.650
1sow NADL-lactate dehydrogenase 1.1.1.27 0.650
1wze NADMalate dehydrogenase / 0.650