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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4c3r ACP Aurora kinase A 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4c3r ACPAurora kinase A 2.7.11.1 0.883
4c3p ACPAurora kinase A 2.7.11.1 0.771
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.759
5l8j ADPAurora kinase A 2.7.11.1 0.741
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.735
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.732
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.725
4ceg ADPAurora kinase A 2.7.11.1 0.725
2dwb ANPAurora kinase A 2.7.11.1 0.724
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.723
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.722
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.721
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.719
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.718
1mq4 ADPAurora kinase A 2.7.11.1 0.716
3c4w ATPRhodopsin kinase / 0.716
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.714
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.713
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.711
3cly ACPFibroblast growth factor receptor 2 / 0.711
3qc9 ADPRhodopsin kinase / 0.711
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.708
4dee ADPAurora kinase A 2.7.11.1 0.708
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.706
4fg8 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.706
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.704
2pup ADPMethylthioribose kinase 2.7.1.100 0.704
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.704
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.703
3ork AGSSerine/threonine protein kinase / 0.701
4n57 ADPAPH(2'')-Id / 0.701
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.699
4xlv ACPInsulin receptor 2.7.10.1 0.698
2wqe ADPAurora kinase A 2.7.11.1 0.697
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.696
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.694
1ol6 ATPAurora kinase A 2.7.11.1 0.691
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.691
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.690
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.689
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.687
2pui ADPMethylthioribose kinase 2.7.1.100 0.687
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.687
5l8k ADPAurora kinase A 2.7.11.1 0.687
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.686
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.686
3ori AGSSerine/threonine protein kinase / 0.686
4ysj ADPCalmodulin-like domain protein kinase / 0.686
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.684
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.684
4q5h ANPProtein kinase OspG 2.7 0.684
5iqh GNPBifunctional AAC/APH 2.3.1 0.684
2pzp ACPFibroblast growth factor receptor 2 / 0.683
3fzp AGSProtein-tyrosine kinase 2-beta 2.7.10.2 0.683
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.683
5l8l ADPAurora kinase A 2.7.11.1 0.683
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.682
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.682
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.682
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.681
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.679
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
4o4d ATPKinase / 0.678
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.677
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.677
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.676
2pyw ADPMethylthioribose kinase 2.7.1.100 0.676
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.676
1pkg ADPMast/stem cell growth factor receptor Kit 2.7.10.1 0.675
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.675
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
2olc ADPMethylthioribose kinase 2.7.1.100 0.674
1i44 ACPInsulin receptor 2.7.10.1 0.673
3c4z ADPRhodopsin kinase / 0.673
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.673
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.672
5dt3 ATPAurora kinase A 2.7.11.1 0.672
5iqf GDPBifunctional AAC/APH 2.3.1 0.672
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.671
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.670
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.670
5dt4 ATPAurora kinase A 2.7.11.1 0.669
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.668
3ort AGSSerine/threonine protein kinase / 0.668
3ung ADPCRISPR system Cmr subunit Cmr2 / 0.668
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
3a8w ATPProtein kinase C iota type 2.7.11.13 0.667
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.666
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.666
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.666
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.665
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.665
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.664
2pul ACPMethylthioribose kinase 2.7.1.100 0.664
2w5a ADPSerine/threonine-protein kinase Nek2 2.7.11.1 0.664
4b8l A0PAurora kinase B-A 2.7.11.1 0.664
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.664
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.664
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.664
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.664
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.663
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.662
3c50 ADPRhodopsin kinase / 0.662
4o4f ATPKinase / 0.662
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.661
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.661
4o0u ADNAurora kinase A 2.7.11.1 0.661
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.660
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.660
1u54 ACPActivated CDC42 kinase 1 / 0.659
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.659
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.659
2eva ADNMitogen-activated protein kinase kinase kinase 7 2.7.11.25 0.657
2yaa ATPDeath-associated protein kinase 2 / 0.657
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.657
3t8o ATPRhodopsin kinase / 0.657
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4o4e ATPKinase / 0.657
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.657
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.656
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.656
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.656
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.655
4jrn ANPRhoptry kinase family protein / 0.655
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.655
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
3pdt ADPMyosin heavy chain kinase A 2.7.11.7 0.653
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.653
5dnr ATPAurora kinase A 2.7.11.1 0.653
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.652
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.652
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.652
3nie ANPMitogen-activated protein kinase / 0.652
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.652
2vqd AP2Biotin carboxylase 6.3.4.14 0.651
4ffl ADPUncharacterized protein / 0.651
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.650
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.650