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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rzp PRF NADPH-dependent 7-cyano-7-deazaguanine reductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rzp PRFNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.850
1eve E20Acetylcholinesterase 3.1.1.7 0.744
1hpz AAPGag-Pol polyprotein 2.7.7.49 0.744
1kbo 340NAD(P)H dehydrogenase [quinone] 1 1.6.5.2 0.744
1m67 BOAGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal 1.1.1.8 0.744
1qvu PRLHTH-type transcriptional regulator QacR / 0.744
1sqi 8694-hydroxyphenylpyruvate dioxygenase / 0.744
1xrp PRO_LEU_GLY_GLYProline iminopeptidase 3.4.11.5 0.744
2f98 NGVAklanonic acid methyl ester cyclase AcmA 5.5.1.23 0.744
2g97 DGBNicotinamide phosphoribosyltransferase 2.4.2.12 0.744
2gz7 D3FOrf1a polyprotein / 0.744
2j3q TFLAcetylcholinesterase 3.1.1.7 0.744
2jle I15Reverse transcriptase/RNaseH / 0.744
2l98 STLTroponin C, slow skeletal and cardiac muscles / 0.744
2mji KTRFatty acid-binding protein, intestinal / 0.744
2oaz I96Methionine aminopeptidase 2 / 0.744
2vcq D25Hematopoietic prostaglandin D synthase / 0.744
2vcw ZZAHematopoietic prostaglandin D synthase / 0.744
2x1z PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic / 0.744
2x20 PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic / 0.744
2x21 PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic / 0.744
2xuj TZ5Acetylcholinesterase 3.1.1.7 0.744
2ybu CX9Acidic mammalian chitinase 3.2.1.14 0.744
3arz I5IChitinase A / 0.744
3dys IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A / 0.744
3f8c HT1Transcriptional regulator, PadR-like family / 0.744
3gus N11Glutathione S-transferase P 2.5.1.18 0.744
3gww SFXNa(+):neurotransmitter symporter (Snf family) / 0.744
3hth PRLEbrA repressor / 0.744
3hyw DCQSulfide-quinone reductase / 0.744
3iis PIDPeridinin-chlorophyll a-binding protein 1, chloroplastic / 0.744
3irx UDRGag-Pol polyprotein 2.7.7.49 0.744
3kxo KXOHematopoietic prostaglandin D synthase / 0.744
3lg5 BTMEpi-isozizaene synthase 4.2.3.37 0.744
3mdv CL6Cholesterol 24-hydroxylase / 0.744
3nc9 TR3Ketohexokinase / 0.744
3nf7 CIWGag-Pol polyprotein / 0.744
3nfa CBJGag-Pol polyprotein / 0.744
3p9t TCLRepressor / 0.744
3qwh KMP17beta-hydroxysteroid dehydrogenase / 0.744
4b1f KRHGlutamate racemase / 0.744
4bbx LKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.744
4chz H75Integrase / 0.744
4cjw CBJIntegrase / 0.744
4dyp 0MSNucleoprotein / 0.744
4fiz CUE17beta-hydroxysteroid dehydrogenase / 0.744
4hg7 NUTE3 ubiquitin-protein ligase Mdm2 6.3.2 0.744
4iks TFDMethionine aminopeptidase 1 / 0.744
4ra3 TFXBeta-2-microglobulin / 0.744
3uxv GUNNADPH-dependent 7-cyano-7-deazaguanine reductase / 0.738
4fgc PQ0NADPH-dependent 7-cyano-7-deazaguanine reductase 1.7.1.13 0.694
2nq7 HM5Methionine aminopeptidase 1 / 0.691
2wey EV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.691
3mzt TFXBeta-2-microglobulin / 0.691
3wi2 P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.691
4ikr PVPMethionine aminopeptidase 1 / 0.691
2o8h 227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.686
2xzg VH1Clathrin heavy chain 1 / 0.686
3g49 3G4Corticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.679
1xdy MTEProtein-methionine-sulfoxide reductase catalytic subunit MsrP / 0.668
1xdq MTEProtein-methionine-sulfoxide reductase catalytic subunit MsrP / 0.664
2qju DSMNa(+):neurotransmitter symporter (Snf family) / 0.660
3cne FMNPutative protease I / 0.660
4yp0 5IQHistidyl-tRNA synthetase, putative / 0.660
3rv7 RVBSalicylate synthase / 0.655
1e1x NW1Cyclin-dependent kinase 2 2.7.11.22 0.653
3sni 546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.653
2ovv PFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.650
3sn7 540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 3.1.4.17 0.650