Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3rhl NAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.386
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.326
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.266
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.264
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.253
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.151
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.008
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.005
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.976
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.971
4i8p NADAminoaldehyde dehydrogenase 1 / 0.958
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.946
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.943
4pz2 NADAldehyde dehydrogenase 2-6 / 0.936
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.933
4i8q NADPutative betaine aldehyde dehyrogenase / 0.933
3b4w NADAldehyde dehydrogenase family protein / 0.919
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.918
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.915
2jg7 NADAntiquitin / 0.911
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.899
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.895
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.880
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.867
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.865
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.863
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.855
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.843
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.840
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.839
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.837
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.835
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.833
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.824
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.818
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.803
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.801
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.798
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.792
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.782
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.774
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.771
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.770
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.768
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.764
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.755
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.752
4pt0 NADAldehyde dehydrogenase / 0.752
4pxl NADAldehyde dehydrogenase3 / 0.749
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.744
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.738
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.730
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.729
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.728
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.727
4i3v NADAldehyde dehydrogenase (NAD+) / 0.724
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.723
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.722
4c3s NADAldehyde Dehydrogenase / 0.721
4i3w NADAldehyde dehydrogenase (NAD+) / 0.721
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.720
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.719
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.718
4h73 NDPAldehyde dehydrogenase / 0.714
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.712
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.712
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.712
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.709
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.708
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.703
3haz NADBifunctional protein PutA / 0.703
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.702
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.699
4f3x NADPutative aldehyde dehydrogenase / 0.690
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.684
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.683
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.683
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.682
4i9b NADPutative betaine aldehyde dehyrogenase / 0.680
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.679
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.677
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.676
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.675
2voj NADAlanine dehydrogenase 1.4.1.1 0.670
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.663
2ilu NDPLactaldehyde dehydrogenase 1.2.1.22 0.656
2vro NDP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.651