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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3o7l ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.025
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.830
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.828
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.818
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.817
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.812
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.807
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.805
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.800
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.791
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.791
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.787
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.785
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.778
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.776
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.775
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.773
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.772
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.771
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.762
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.762
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.754
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.752
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.750
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.749
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.746
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.745
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.744
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.740
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.739
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.738
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.737
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.736
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.733
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.733
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.731
2pml ANPUncharacterized protein / 0.729
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.728
5dt3 ATPAurora kinase A 2.7.11.1 0.727
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.726
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.726
4ysj ADPCalmodulin-like domain protein kinase / 0.725
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.724
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.719
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.719
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.718
5dr2 ATPAurora kinase A 2.7.11.1 0.718
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.714
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.714
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.712
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.712
1ol6 ATPAurora kinase A 2.7.11.1 0.711
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.710
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.709
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.708
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.705
5drd ATPAurora kinase A 2.7.11.1 0.703
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.702
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.702
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.701
3c4z ADPRhodopsin kinase / 0.700
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.700
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.700
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.699
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.699
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.698
4qny ANPMitogen activated protein kinase, putative / 0.698
5ce3 ADPProtein kinase YopO / 0.698
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.697
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.697
4gyi ADPUncharacterized protein / 0.697
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.697
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.696
4dee ADPAurora kinase A 2.7.11.1 0.696
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.694
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.693
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.691
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.691
5eg3 ACPFibroblast growth factor receptor 2 / 0.691
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.690
2olc ADPMethylthioribose kinase 2.7.1.100 0.690
2zdg ADPD-alanine--D-alanine ligase / 0.690
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.690
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
5dt4 ATPAurora kinase A 2.7.11.1 0.690
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.689
4o4e ATPKinase / 0.689
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.688
4o4f ATPKinase / 0.688
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.687
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.687
4aw0 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.687
5ckw ANPUncharacterized protein / 0.686
3t8o ATPRhodopsin kinase / 0.684
4xlv ACPInsulin receptor 2.7.10.1 0.684
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.682
3c50 ADPRhodopsin kinase / 0.682
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.682
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.682
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.682
4xx9 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.682
5dnr ATPAurora kinase A 2.7.11.1 0.682
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.680
2pyw ADPMethylthioribose kinase 2.7.1.100 0.679
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.679
1mq4 ADPAurora kinase A 2.7.11.1 0.678
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.678
3cly ACPFibroblast growth factor receptor 2 / 0.677
4ceg ADPAurora kinase A 2.7.11.1 0.677
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.676
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.675
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.675
3g51 ANPRibosomal protein S6 kinase alpha-3 2.7.11.1 0.675
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.675
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.674
2pul ACPMethylthioribose kinase 2.7.1.100 0.674
2vqd AP2Biotin carboxylase 6.3.4.14 0.674
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.674
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.673
4utd ACPAurora kinase A 2.7.11.1 0.673
2dwb ANPAurora kinase A 2.7.11.1 0.672
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.672
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.670
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.670
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.670
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.669
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.669
2yaa ATPDeath-associated protein kinase 2 / 0.668
3g8d ADPBiotin carboxylase 6.3.4.14 0.668
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.667
2if8 ADPInositol polyphosphate multikinase 2.7.1.151 0.667
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.667
3qc9 ADPRhodopsin kinase / 0.667
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.666
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.666
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.666
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.666
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.666
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.666
5dn3 ATPAurora kinase A 2.7.11.1 0.666
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.665
4fg7 ATPCalcium/calmodulin-dependent protein kinase type 1 2.7.11.17 0.665
4q5h ANPProtein kinase OspG 2.7 0.665
1m0w ANPGlutathione synthetase 6.3.2.3 0.664
1ol5 ADPAurora kinase A 2.7.11.1 0.664
4o1p ANPRibonuclease L / 0.664
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.664
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.662
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.662
5iqf GDPBifunctional AAC/APH 2.3.1 0.662
4c3r ACPAurora kinase A 2.7.11.1 0.661
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.660
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.660
2pui ADPMethylthioribose kinase 2.7.1.100 0.660
2pup ADPMethylthioribose kinase 2.7.1.100 0.660
1ol7 ADPAurora kinase A 2.7.11.1 0.659
3wnz ADPAlanine--anticapsin ligase / 0.659
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.659
1cm8 ANPMitogen-activated protein kinase 12 / 0.658
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.658
5la6 ACPTubulin tyrosine ligase / 0.658
1px2 ATPSynapsin-1 / 0.657
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.657
3nie ANPMitogen-activated protein kinase / 0.657
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.657
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.656
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.656
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.656
2wqe ADPAurora kinase A 2.7.11.1 0.656
4axd ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.656
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.655
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.653
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.653
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.653
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.653
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.653
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.652
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.652
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.652
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.651
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.650
3wo1 ADPAlanine--anticapsin ligase / 0.650