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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3o4r NAP Dehydrogenase/reductase SDR family member 4 1.1.1.184

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3o4r NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 1.403
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 1.158
1x7g NAPPutative ketoacyl reductase 1.3.1 0.946
4dbz NDPPutative ketoacyl reductase 1.3.1 0.924
3qrw NDPPutative ketoacyl reductase 1.3.1 0.901
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.899
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.887
1x7h NDPPutative ketoacyl reductase 1.3.1 0.885
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.859
2jah NDPClavaldehyde dehydrogenase / 0.856
3ai3 NDPNADPH-sorbose reductase / 0.848
4iqg NAPShort-chain dehydrogenase/reductase SDR / 0.847
4dc1 NDPPutative ketoacyl reductase 1.3.1 0.846
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.829
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.826
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.824
4fn4 NADShort chain dehydrogenase / 0.824
4hwk NAPSepiapterin reductase 1.1.1.153 0.819
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.818
3ai2 NDPNADPH-sorbose reductase / 0.815
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.813
1w4z NAPPutative ketoacyl reductase 1.3.1 0.811
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.810
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.809
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.809
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.808
3u4c NDPNADPH-dependent reductase BacG / 0.807
3p19 NDPPutative blue fluorescent protein / 0.804
1pr9 NAPL-xylulose reductase 1.1.1.10 0.803
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.803
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.800
2wsb NADGalactitol dehydrogenase / 0.799
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.799
3uce NDPDehydrogenase / 0.799
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.796
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.793
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.792
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.791
1ae1 NAPTropinone reductase 1 / 0.790
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.789
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.788
4kwh NAPReductase homolog / 0.787
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.786
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.784
4j7u NAPSepiapterin reductase 1.1.1.153 0.784
3r3s NADPutative oxidoreductase / 0.782
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.781
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.781
3s55 NADPutative short-chain dehydrogenase/reductase / 0.780
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.778
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.775
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.775
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.775
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.775
1oaa NAPSepiapterin reductase 1.1.1.153 0.771
3geg NADShort-chain dehydrogenase/reductase SDR / 0.768
3o26 NDPSalutaridine reductase / 0.765
3sx2 NADUncharacterized protein / 0.764
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.756
4j7x NAPSepiapterin reductase 1.1.1.153 0.756
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.755
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.753
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.753
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.753
3tsc NADUncharacterized protein / 0.752
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.751
3sju NDPKeto reductase / 0.751
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.750
3qwf NAP17beta-hydroxysteroid dehydrogenase / 0.750
5jla NADPutative short-chain dehydrogenase/reductase / 0.750
5jyd NADShort chain dehydrogenase / 0.749
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.748
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.748
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.747
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.746
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.746
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.746
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.744
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.743
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.742
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.741
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.735
4xyb NDPFormate dehydrogenase / 0.735
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.731
2dte NAIGlucose 1-dehydrogenase related protein / 0.730
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.729
4hxy NDPPlm1 / 0.729
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.729
2yut NAPPutative short-chain oxidoreductase / 0.728
4b79 NADProbable short-chain dehydrogenase / 0.728
4wec NADShort chain dehydrogenase / 0.728
1nfr NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.727
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.727
3mje NDPAmphB / 0.726
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.726
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.722
3tn7 NJPShort-chain alcohol dehydrogenase / 0.721
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.718
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.716
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.716
2bd0 NAPSepiapterin reductase / 0.715
2y99 NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase 1.3.1.56 0.713
1sny NAPLD36273p / 0.712
1i3l NADUDP-glucose 4-epimerase / 0.711
4yag NAIC alpha-dehydrogenase / 0.710
3bmo NAPPteridine reductase / 0.709
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.707
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.705
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.704
1ahh NAD7-alpha-hydroxysteroid dehydrogenase 1.1.1.159 0.703
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.702
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.702
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.701
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.701
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.700
2p5y NADUDP-glucose 4-epimerase / 0.699
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.696
1nai NADUDP-glucose 4-epimerase 5.1.3.2 0.694
3d3w NAPL-xylulose reductase 1.1.1.10 0.694
4bmv NAPShort-chain dehydrogenase / 0.694
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.694
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.693
2nq8 ZIDEnoyl-ACP reductase / 0.693
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.690
3oew NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.690
2b4q NAPRhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.688
1sby NADAlcohol dehydrogenase 1.1.1.1 0.687
1xkq NDPUncharacterized protein / 0.687
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.687
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.686
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.686
3l77 NJPShort-chain alcohol dehydrogenase / 0.685
4fj1 NAP17beta-hydroxysteroid dehydrogenase / 0.685
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.684
4yai NAIC alpha-dehydrogenase / 0.682
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.681
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.680
3wmx NADNAD dependent epimerase/dehydratase / 0.680
2c29 NAPDihydroflavonol 4-reductase / 0.679
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.679
3h4v NAPPteridine reductase 1 1.5.1.33 0.679
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.679
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.679
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.678
2bgm NAJSecoisolariciresinol dehydrogenase 1.1.1.331 0.677
4b4o NDPEpimerase family protein SDR39U1 / 0.677
2bfo NDPPteridine reductase 1 1.5.1.33 0.676
4u7w NDPMxaA / 0.674
5lc1 NADL-threonine 3-dehydrogenase / 0.674
3a4v NADNDP-sugar epimerase / 0.672
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.671
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.670
3a9w NADNDP-sugar epimerase / 0.670
4cql NADEstradiol 17-beta-dehydrogenase 8 1.1.1.62 0.669
4imp NDPPolyketide synthase extender modules 3-4 / 0.669
4n5n NAPAcetoacetyl-CoA reductase 1.1.1.36 0.668
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.667
5b1y NDP3-oxoacyl-[acyl-carrier-protein] reductase / 0.667
4yac NAIC alpha-dehydrogenase / 0.666
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.663
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.662
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.661
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.661
3ajr NADNDP-sugar epimerase / 0.661
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.661
4qec NAPElxO / 0.661
1fk8 NAD3-alpha-hydroxysteroid dehydrogenase/carbonyl reductase 1.1.1.50 0.660
3aw9 NADNAD-dependent epimerase/dehydratase / 0.660
4j16 NAPNAD(P) transhydrogenase subunit beta / 0.660
4clo NAPPteridine reductase / 0.658
3ko8 NADNAD-dependent epimerase/dehydratase / 0.653
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.653
1g1a NADdTDP-glucose 4,6-dehydratase / 0.652
1pt9 TAPNAD(P) transhydrogenase, mitochondrial 1.6.1.2 0.651
1u31 NDPNAD(P) transhydrogenase, mitochondrial 1.6.1.2 0.651
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.650
5bt9 NAP3-oxoacyl-(Acyl-carrier-protein) reductase / 0.650