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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3iwj NAD Aminoaldehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3iwj NADAminoaldehyde dehydrogenase / 0.870
4i9b NADPutative betaine aldehyde dehyrogenase / 0.846
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.782
4i8q NADPutative betaine aldehyde dehyrogenase / 0.775
4pz2 NADAldehyde dehydrogenase 2-6 / 0.772
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.769
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.765
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.763
4pxl NADAldehyde dehydrogenase3 / 0.760
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.758
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.758
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.755
4pt0 NADAldehyde dehydrogenase / 0.754
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.743
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.742
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.741
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.736
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.736
4nmj NAPAldehyde dehydrogenase / 0.736
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.735
3b4w NADAldehyde dehydrogenase family protein / 0.734
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.732
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.732
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.730
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.727
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.726
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.724
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.723
5dib NADBetaine-aldehyde dehydrogenase / 0.722
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.721
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.720
4nmk NAPAldehyde dehydrogenase / 0.719
1bi9 NADRetinal dehydrogenase 2 / 0.718
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.716
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
4h73 NDPAldehyde dehydrogenase / 0.716
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.711
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.710
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.704
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.703
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.701
4i3v NADAldehyde dehydrogenase (NAD+) / 0.700
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.699
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.696
5eyu NADBetaine-aldehyde dehydrogenase / 0.696
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.694
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.693
3haz NADBifunctional protein PutA / 0.693
5ez4 NADBetaine-aldehyde dehydrogenase / 0.692
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.688
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.688
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.687
4f3x NADPutative aldehyde dehydrogenase / 0.686
2xdr NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.677
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.672
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.670
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.669
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.665
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.665
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.663
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.663
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.663
4i8p NADAminoaldehyde dehydrogenase 1 / 0.662
1r6t TYMTryptophan--tRNA ligase, cytoplasmic 6.1.1.2 0.658
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.656
4j7x NAPSepiapterin reductase 1.1.1.153 0.655
2y53 NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.651