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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3efv NAD Putative succinate-semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
3efv NADPutative succinate-semialdehyde dehydrogenase / 1.263
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.047
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.043
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.011
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.003
3b4w NADAldehyde dehydrogenase family protein / 1.001
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.979
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.977
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.969
4i8p NADAminoaldehyde dehydrogenase 1 / 0.954
4i8q NADPutative betaine aldehyde dehyrogenase / 0.953
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.953
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.943
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.930
4pz2 NADAldehyde dehydrogenase 2-6 / 0.924
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.910
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.909
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.905
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.899
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.895
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.884
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.883
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.881
2jg7 NADAntiquitin / 0.877
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.872
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.872
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.864
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.863
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.856
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.854
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.853
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.851
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.843
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.835
3haz NADBifunctional protein PutA / 0.823
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.816
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.814
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.813
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.800
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.799
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.765
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.763
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.759
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.750
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.748
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.724
4i9b NADPutative betaine aldehyde dehyrogenase / 0.724
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
4h73 NDPAldehyde dehydrogenase / 0.722
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.719
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.719
4nmj NAPAldehyde dehydrogenase / 0.718
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.713
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.713
4pxl NADAldehyde dehydrogenase3 / 0.713
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.712
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.710
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.708
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.707
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.707
4i3w NADAldehyde dehydrogenase (NAD+) / 0.705
4pt0 NADAldehyde dehydrogenase / 0.705
4f3x NADPutative aldehyde dehydrogenase / 0.702
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.701
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.701
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.695
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.693
4nmk NAPAldehyde dehydrogenase / 0.691
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.688
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.687
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.686
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.684
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.683
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.680
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.679
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.675
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.671
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.670
4c3s NADAldehyde Dehydrogenase / 0.669
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.666
5eyu NADBetaine-aldehyde dehydrogenase / 0.661
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.658
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.651