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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2wep ADP ATP-dependent molecular chaperone HSP82

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2wep ADPATP-dependent molecular chaperone HSP82 / 0.790
4gqt ADPHeat shock protein 90 / 0.745
3t1k ANPHeat shock protein HSP 90-alpha / 0.729
3t10 ACPHeat shock protein HSP 90-alpha / 0.726
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.724
4xcj ADPHeat shock cognate 90 kDa protein / 0.720
1byq ADPHeat shock protein HSP 90-alpha / 0.719
2xk2 ADPHeat shock protein HSP 90-alpha / 0.718
3t0z ATPHeat shock protein HSP 90-alpha / 0.718
1amw ADPATP-dependent molecular chaperone HSP82 / 0.716
4xc0 ACPHeat shock cognate 90 kDa protein / 0.711
4xcl AGSHeat shock cognate 90 kDa protein / 0.710
1yt0 ADPEndoplasmin / 0.699
2ior ADPChaperone protein HtpG / 0.689
2xcm ADPCytosolic heat shock protein 90 / 0.688
3t2s AGSHeat shock protein HSP 90-alpha / 0.687
2yeg XQGHeat shock protein HSP 90-alpha / 0.682
2yef ANPHeat shock protein HSP 90-alpha / 0.678
1ea6 ADPMismatch repair endonuclease PMS2 3.1 0.671
1qy5 NECEndoplasmin / 0.671
2gqp PA7Endoplasmin / 0.669
1u0y PA7Endoplasmin / 0.665
1u2o NECEndoplasmin / 0.664
1y4s ADPChaperone protein HtpG / 0.659
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.656
1m8g NADNicotinamide-nucleotide adenylyltransferase 2.7.7.1 0.655
4ivg ANPTNF receptor-associated protein 1 / 0.653
4gt8 ADPSensor protein VraS 2.7.13.3 0.651
3lij ANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands / 0.650