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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2o2q NAP Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.329
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.191
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.189
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.172
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.165
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.151
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 1.036
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.958
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.932
4i8p NADAminoaldehyde dehydrogenase 1 / 0.922
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.920
4i8q NADPutative betaine aldehyde dehyrogenase / 0.913
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.905
4pz2 NADAldehyde dehydrogenase 2-6 / 0.899
3b4w NADAldehyde dehydrogenase family protein / 0.898
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.884
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.880
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.877
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.872
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.871
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.862
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.857
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.852
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.851
2jg7 NADAntiquitin / 0.846
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.839
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.832
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.827
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.826
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.815
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.805
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.801
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.800
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.800
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.800
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.798
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.792
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.769
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.764
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.762
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.756
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.755
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.753
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.753
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.751
4pxl NADAldehyde dehydrogenase3 / 0.742
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.738
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.737
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.736
4i3w NADAldehyde dehydrogenase (NAD+) / 0.733
3haz NADBifunctional protein PutA / 0.729
4h73 NDPAldehyde dehydrogenase / 0.729
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.727
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.725
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.723
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.722
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.719
4i3v NADAldehyde dehydrogenase (NAD+) / 0.718
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.717
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.717
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.716
4i9b NADPutative betaine aldehyde dehyrogenase / 0.714
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.714
4pt0 NADAldehyde dehydrogenase / 0.712
4f3x NADPutative aldehyde dehydrogenase / 0.708
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.707
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.706
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.704
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.703
4nmk NAPAldehyde dehydrogenase / 0.700
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.700
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.699
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.698
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.693
1bi9 NADRetinal dehydrogenase 2 / 0.691
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.691
4nmj NAPAldehyde dehydrogenase / 0.689
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.687
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.686
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.686
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.678
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.672
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.670
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.666
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.662
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.660
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.654