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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2o1u ANP Endoplasmin

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2o1u ANPEndoplasmin / 0.848
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.779
2ior ADPChaperone protein HtpG / 0.764
1yt0 ADPEndoplasmin / 0.743
4xcl AGSHeat shock cognate 90 kDa protein / 0.742
4xcj ADPHeat shock cognate 90 kDa protein / 0.734
2yef ANPHeat shock protein HSP 90-alpha / 0.727
3t0z ATPHeat shock protein HSP 90-alpha / 0.724
2xk2 ADPHeat shock protein HSP 90-alpha / 0.721
3t1k ANPHeat shock protein HSP 90-alpha / 0.721
4xc0 ACPHeat shock cognate 90 kDa protein / 0.721
1byq ADPHeat shock protein HSP 90-alpha / 0.720
1y4s ADPChaperone protein HtpG / 0.715
3t10 ACPHeat shock protein HSP 90-alpha / 0.715
3t2s AGSHeat shock protein HSP 90-alpha / 0.707
2xcm ADPCytosolic heat shock protein 90 / 0.703
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.695
3ied AN2HSP90 / 0.694
4ivg ANPTNF receptor-associated protein 1 / 0.693
4wud ANPDNA gyrase subunit B / 0.684
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.683
4gt8 ADPSensor protein VraS 2.7.13.3 0.682
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.680
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.678
4gqt ADPHeat shock protein 90 / 0.677
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.676
4ipe ANPTNF receptor-associated protein 1 / 0.676
2o1v ADPEndoplasmin / 0.675
4wuc ANPDNA gyrase subunit B / 0.675
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.671
3h4l ANPDNA mismatch repair protein PMS1 / 0.669
1th8 ADPAnti-sigma F factor / 0.665
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.664
4r39 ANPBlue-light-activated histidine kinase 2 2.7.13.3 0.663
1ea6 ADPMismatch repair endonuclease PMS2 3.1 0.661
1amw ADPATP-dependent molecular chaperone HSP82 / 0.659
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.657
2yeg XQGHeat shock protein HSP 90-alpha / 0.653