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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ntj P1H Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ntj P1HEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 1.214
2nv6 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.886
4dre NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.884
2aqh NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.872
2h9i EADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.867
2idz ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.862
3oey NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.859
3of2 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.859
4dti NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.845
4dqu NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.840
2aqk NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.837
4bii NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.830
4trn NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.822
4bqp NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.814
1eny NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.800
5cpb NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.800
2aq8 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.799
4zju NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.795
4bgi NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.794
2ntv P1HEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.793
2aqi NAIEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.791
2wyv NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.786
2pr2 DG1Enoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.778
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.771
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.769
2q2v NADBeta-D-hydroxybutyrate dehydrogenase / 0.767
2ztl NADD(-)-3-hydroxybutyrate dehydrogenase / 0.767
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.765
3p19 NDPPutative blue fluorescent protein / 0.765
2ie0 ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.761
2gdz NAD15-hydroxyprostaglandin dehydrogenase [NAD(+)] 1.1.1.141 0.754
3r3s NADPutative oxidoreductase / 0.752
2ieb ZIDEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.750
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.747
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.747
3vdq NAD3-hydroxybutyrate dehydrogenase / 0.745
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.740
2dkn NAI3-alpha-hydroxysteroid dehydrogenase / 0.738
3w8d NAD3-hydroxybutyrate dehydrogenase / 0.738
3wds NADNADH-dependent quinuclidinone reductase / 0.738
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.737
5jsf NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.737
5js6 NAD17-beta-hydroxysteroid dehydrogenase 14 1.1.1 0.736
2b37 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.735
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.733
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.731
4b79 NADProbable short-chain dehydrogenase / 0.731
4oxy NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.731
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.728
3sx2 NADUncharacterized protein / 0.724
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.724
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.723
3uic NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.722
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.721
3ak4 NADNADH-dependent quinuclidinone reductase / 0.719
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.715
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.715
1w4z NAPPutative ketoacyl reductase 1.3.1 0.714
4m87 NADEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.714
5jyd NADShort chain dehydrogenase / 0.714
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.713
3o03 NAPDehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) / 0.713
3o26 NDPSalutaridine reductase / 0.713
4kwh NAPReductase homolog / 0.713
4qxm NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.713
2b35 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.712
1h5q NAPNADP-dependent mannitol dehydrogenase 1.1.1.138 0.710
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.710
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.709
3tn7 NJPShort-chain alcohol dehydrogenase / 0.708
4fn4 NADShort chain dehydrogenase / 0.707
4j7u NAPSepiapterin reductase 1.1.1.153 0.707
4nbt NAD3-oxoacyl-[acyl-carrier-protein] reductase / 0.706
1x7h NDPPutative ketoacyl reductase 1.3.1 0.705
4clo NAPPteridine reductase / 0.705
4hwk NAPSepiapterin reductase 1.1.1.153 0.705
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.705
4yag NAIC alpha-dehydrogenase / 0.704
1edo NAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic 1.1.1.100 0.702
4gh5 NADShort-chain dehydrogenase/reductase SDR / 0.702
2dte NAIGlucose 1-dehydrogenase related protein / 0.700
2bd0 NAPSepiapterin reductase / 0.699
5jla NADPutative short-chain dehydrogenase/reductase / 0.699
1e3w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.697
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.697
2yut NAPPutative short-chain oxidoreductase / 0.696
3geg NADShort-chain dehydrogenase/reductase SDR / 0.696
4o1m NADEnoyl-acyl carrier reductase / 0.695
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.694
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.694
4o0l NDPNADPH-dependent 3-quinuclidinone reductase / 0.694
3ai2 NDPNADPH-sorbose reductase / 0.693
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.692
3bmo NAPPteridine reductase / 0.692
2bfo NDPPteridine reductase 1 1.5.1.33 0.691
4qec NAPElxO / 0.690
4qed NAPElxO / 0.690
2ztu NADD(-)-3-hydroxybutyrate dehydrogenase / 0.689
1u7t NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.688
4yai NAIC alpha-dehydrogenase / 0.688
1g0n NDPTetrahydroxynaphthalene reductase 1.1.1.252 0.685
3l77 NJPShort-chain alcohol dehydrogenase / 0.685
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.684
1cyd NDPCarbonyl reductase [NADPH] 2 1.1.1.184 0.682
4bmv NAPShort-chain dehydrogenase / 0.680
4k6f NAPPutative Acetoacetyl-CoA reductase / 0.680
1ipe NDPTropinone reductase 2 1.1.1.236 0.677
3d3w NAPL-xylulose reductase 1.1.1.10 0.677
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.676
1oaa NAPSepiapterin reductase 1.1.1.153 0.674
4c7k NAPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.674
5b1y NDP3-oxoacyl-[acyl-carrier-protein] reductase / 0.674
3tsc NADUncharacterized protein / 0.673
1b2l NDCAlcohol dehydrogenase 1.1.1.1 0.672
2p5y NADUDP-glucose 4-epimerase / 0.672
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.672
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.669
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.669
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.669
1vrw NAIEnoyl-ACP reductase / 0.667
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.665
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.664
2q2q NADBeta-D-hydroxybutyrate dehydrogenase / 0.664
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.661
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.659
4eue NAITrans-2-enoyl-CoA reductase [NADH] / 0.658
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.656
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.655
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.655
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.654
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.653
3icp NADNAD-dependent epimerase/dehydratase / 0.652
3ruh NADUDP-N-acetylglucosamine 4-epimerase / 0.652
1zem NADXylitol dehydrogenase / 0.650