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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ehq NAP 1-pyrroline-5-carboxylate dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 1.351
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.214
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 1.212
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.192
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.185
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.163
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 1.112
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 1.024
4pz2 NADAldehyde dehydrogenase 2-6 / 1.024
3efv NADPutative succinate-semialdehyde dehydrogenase / 1.011
3b4w NADAldehyde dehydrogenase family protein / 0.994
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.975
4i8p NADAminoaldehyde dehydrogenase 1 / 0.953
2jg7 NADAntiquitin / 0.951
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.943
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.941
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.931
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.915
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.915
4i8q NADPutative betaine aldehyde dehyrogenase / 0.915
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.910
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.910
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.906
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.904
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.902
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.901
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.892
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.889
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.883
3haz NADBifunctional protein PutA / 0.875
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.867
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.866
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.866
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.865
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.861
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.858
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.858
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.857
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.852
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.832
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.818
4nmk NAPAldehyde dehydrogenase / 0.810
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.799
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.784
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.782
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.769
4c3s NADAldehyde Dehydrogenase / 0.761
4h73 NDPAldehyde dehydrogenase / 0.761
4i9b NADPutative betaine aldehyde dehyrogenase / 0.760
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.756
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.756
4nmj NAPAldehyde dehydrogenase / 0.752
4i3v NADAldehyde dehydrogenase (NAD+) / 0.750
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.748
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.727
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.725
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
4i3w NADAldehyde dehydrogenase (NAD+) / 0.721
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.719
4f3x NADPutative aldehyde dehydrogenase / 0.715
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.714
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.711
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.706
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.702
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.701
1bi9 NADRetinal dehydrogenase 2 / 0.696
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.695
2ilu NDPLactaldehyde dehydrogenase 1.2.1.22 0.692
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.687
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.683
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.675
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.663
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.662
1eyy NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.660
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.656
3onw GDPGuanine nucleotide-binding protein G(i) subunit alpha-1 / 0.655
3qe2 NAPNADPH--cytochrome P450 reductase / 0.653
3rhh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.650