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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xr1 ANP Serine/threonine-protein kinase pim-1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.905
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.754
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.736
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.731
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.725
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.723
2olc ADPMethylthioribose kinase 2.7.1.100 0.722
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.722
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.718
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.718
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.717
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.716
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.715
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.715
5iqb GNPBifunctional AAC/APH 2.3.1 0.714
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.713
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.713
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.711
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.709
4gyi ADPUncharacterized protein / 0.708
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.707
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.706
5ce3 ADPProtein kinase YopO / 0.706
1m0w ANPGlutathione synthetase 6.3.2.3 0.705
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.705
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.704
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.704
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.703
5iqf GDPBifunctional AAC/APH 2.3.1 0.703
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.702
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.698
2pul ACPMethylthioribose kinase 2.7.1.100 0.697
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.697
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.697
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.697
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.696
2pml ANPUncharacterized protein / 0.695
4qny ANPMitogen activated protein kinase, putative / 0.695
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.694
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.693
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.693
2pun ACPMethylthioribose kinase 2.7.1.100 0.691
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.691
2pui ADPMethylthioribose kinase 2.7.1.100 0.690
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.689
3llt ANPProtein serine/threonine kinase-1 / 0.688
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.687
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.685
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.685
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.684
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.683
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.682
5dos ATPAurora kinase A 2.7.11.1 0.682
5iqh GNPBifunctional AAC/APH 2.3.1 0.682
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.681
3c4z ADPRhodopsin kinase / 0.681
4ceg ADPAurora kinase A 2.7.11.1 0.681
4utd ACPAurora kinase A 2.7.11.1 0.681
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.680
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.680
4ork GDPBifunctional AAC/APH 2.3.1 0.680
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.679
2vqd AP2Biotin carboxylase 6.3.4.14 0.679
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.678
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.678
3wo1 ADPAlanine--anticapsin ligase / 0.678
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.677
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.677
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.677
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.677
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.676
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.676
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.675
4dee ADPAurora kinase A 2.7.11.1 0.675
5byl GCPBifunctional AAC/APH 2.3.1 0.675
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.674
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.674
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.673
2yaa ATPDeath-associated protein kinase 2 / 0.673
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.673
5ckw ANPUncharacterized protein / 0.673
3g8c ADPBiotin carboxylase 6.3.4.14 0.672
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.672
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.670
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.669
1ol6 ATPAurora kinase A 2.7.11.1 0.668
3t8o ATPRhodopsin kinase / 0.668
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.668
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.668
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.666
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.665
2pyw ADPMethylthioribose kinase 2.7.1.100 0.665
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.665
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.665
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.665
4o4d ATPKinase / 0.665
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.664
5iqe GNPBifunctional AAC/APH 2.3.1 0.664
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.663
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.663
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.663
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.662
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.662
4xlv ACPInsulin receptor 2.7.10.1 0.662
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.661
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.661
3tdw GDPGentamicin resistance protein / 0.661
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.661
5dr2 ATPAurora kinase A 2.7.11.1 0.661
5dt4 ATPAurora kinase A 2.7.11.1 0.661
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.660
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.659
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.659
5eg3 ACPFibroblast growth factor receptor 2 / 0.658
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.657
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.657
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.657
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.656
5dt3 ATPAurora kinase A 2.7.11.1 0.656
3c50 ADPRhodopsin kinase / 0.655
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.654
3q5i ANPProtein kinase, putative / 0.654
3vjo ANPEpidermal growth factor receptor 2.7.10.1 0.654
3x04 GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta 2.7.1.149 0.654
2py3 ACPFibroblast growth factor receptor 2 / 0.653
2zdg ADPD-alanine--D-alanine ligase / 0.653
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.653
2pup ADPMethylthioribose kinase 2.7.1.100 0.652
3c4w ATPRhodopsin kinase / 0.652
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.652
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.651
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.651
2pzp ACPFibroblast growth factor receptor 2 / 0.651
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.651
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.650
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.650
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.650
4ffr ATPUncharacterized protein / 0.650
4n57 ADPAPH(2'')-Id / 0.650