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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1r37 NAD NAD-dependent alcohol dehydrogenase 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 1.460
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 1.119
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 1.109
1h2b NAJNAD-dependent alcohol dehydrogenase / 1.042
1yqd NAPSinapyl alcohol dehydrogenase / 0.981
3jv7 NADSecondary alcohol dehydrogenase / 0.974
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.973
3wle NAD(R)-specific carbonyl reductase / 0.962
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.962
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.949
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.945
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.944
3two NDPMannitol dehydrogenase / 0.941
4c4o NADSADH / 0.934
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.934
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.932
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.930
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.930
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.928
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.928
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.924
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.923
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.918
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.915
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.902
2xaa NADSecondary alcohol dehydrogenase / 0.896
4oaq NDPR-specific carbonyl reductase / 0.894
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.891
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.890
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.888
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.886
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.881
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.874
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.872
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.866
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.861
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.856
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.848
1yqx NAPSinapyl alcohol dehydrogenase / 0.843
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.841
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.841
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.840
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.836
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.831
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.824
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.823
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.822
1uxj NADMalate dehydrogenase / 0.822
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.811
1uxk NADMalate dehydrogenase / 0.807
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.807
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.806
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.802
1o6z NADMalate dehydrogenase / 0.802
4j43 NADUncharacterized protein / 0.801
1x7d NADPutative ornithine cyclodeaminase / 0.797
1gv0 NADMalate dehydrogenase / 0.794
2vhx NADAlanine dehydrogenase 1.4.1.1 0.786
2x0i NAIMalate dehydrogenase / 0.786
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.785
1u7h NADPutative ornithine cyclodeaminase / 0.783
1pzh NADLactate dehydrogenase / 0.781
1llu NADAlcohol dehydrogenase / 0.775
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.775
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.775
4b7x NAPProbable oxidoreductase / 0.774
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.773
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.766
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.761
4rqu NADAlcohol dehydrogenase class-P / 0.760
5a1t NAIL-lactate dehydrogenase / 0.759
4j49 NADUncharacterized protein / 0.758
2y05 NAPProstaglandin reductase 1 / 0.756
4jk3 NADUncharacterized protein / 0.754
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.752
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.752
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.750
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.747
1ib6 NADMalate dehydrogenase / 0.747
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.746
1sow NADL-lactate dehydrogenase 1.1.1.27 0.745
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.740
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.739
3keo NADRedox-sensing transcriptional repressor Rex / 0.739
2nad NADFormate dehydrogenase / 0.738
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.738
4j4b NAIUncharacterized protein / 0.738
1pjc NADAlanine dehydrogenase / 0.737
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.736
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.735
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.734
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.733
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.732
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.730
5a02 NAPGlucose-fructose oxidoreductase / 0.728
2o4c NADErythronate-4-phosphate dehydrogenase / 0.726
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.725
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.725
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.724
4k28 NADShikimate dehydrogenase family protein / 0.722
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.722
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.722
3tqh NDPQuinone oxidoreductase / 0.721
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.718
2gsd NADFormate dehydrogenase / 0.716
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.715
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.713
1emd NADMalate dehydrogenase / 0.712
3adp NAILambda-crystallin 1.1.1.45 0.711
4ros APRMalate dehydrogenase / 0.711
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.711
1f8f NADBenzyl alcohol dehydrogenase / 0.710
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.706
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.705
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.705
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.704
4z0p NDPNAD-dependent dehydrogenase / 0.704
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.703
1pzf A3DLactate dehydrogenase / 0.703
2ph5 NADHomospermidine synthase / 0.702
2x0r NADMalate dehydrogenase / 0.701
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.700
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.700
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.699
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.699
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.696
4hnh NAPNAD-dependent epimerase/dehydratase / 0.696
4y1b NAPAntE / 0.695
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.694
1b8u NADMalate dehydrogenase / 0.693
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.693
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.691
3wsw NADL-lactate dehydrogenase / 0.691
4j49 NAIUncharacterized protein / 0.691
4l0q NADAlcohol dehydrogenase class-3 / 0.691
3d64 NADAdenosylhomocysteinase / 0.690
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.690
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.689
3iup NDPPossible NADH oxidoreductase / 0.688
2vna NAPProstaglandin reductase 2 1.3.1.48 0.685
2fkn NADUrocanate hydratase 4.2.1.49 0.684
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.684
3q2k NAIProbable oxidoreductase / 0.683
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.682
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.682
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.682
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.681
3p19 NDPPutative blue fluorescent protein / 0.681
4i1i NADMalate dehydrogenase / 0.680
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.678
2dvm NAD439aa long hypothetical malate oxidoreductase (NAD) [malic enzyme] / 0.678
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.678
2c0c NAPProstaglandin reductase 3 1 0.677
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.677
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.676
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.676
1bmd NADMalate dehydrogenase / 0.675
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.674
4x3q SAHSibL / 0.674
2ome NADC-terminal-binding protein 2 / 0.672
3ikt NADRedox-sensing transcriptional repressor Rex / 0.672
1c1d NAIPhenylalanine dehydrogenase / 0.671
3ggg NADPrephenate dehydrogenase / 0.671
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.669
3nx4 NAPPutative oxidoreductase / 0.669
2p9g NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.668
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.668
1b8v NADMalate dehydrogenase / 0.667
3qvs NADMyo-inositol-1-phosphate synthase (Ino1) / 0.667
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.666
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.666
2v7g NADUrocanate hydratase 4.2.1.49 0.666
3m2t NADProbable dehydrogenase / 0.666
1ie3 NADMalate dehydrogenase / 0.665
1wzi NDPMalate dehydrogenase / 0.665
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.665
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.664
2oby NAPQuinone oxidoreductase PIG3 1 0.664
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.664
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.664
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.664
4y0k NAPAntE / 0.662
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.662
1j49 NADD-lactate dehydrogenase 1.1.1.28 0.661
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
1vi2 NADQuinate/shikimate dehydrogenase / 0.661
3jyn NDPQuinone oxidoreductase / 0.661
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.660
4wlo NAIMalate dehydrogenase, mitochondrial 1.1.1.37 0.660
1wvg APRCDP-glucose 4,6-dehydratase 4.2.1.45 0.659
3ket NADRedox-sensing transcriptional repressor Rex / 0.659
5a04 NDPGlucose-fructose oxidoreductase / 0.659
1i36 NAPConserved protein / 0.658
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.658
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.658
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.658
4xye NADFormate dehydrogenase / 0.658
4jji NADAlcohol dehydrogenase class-3 / 0.657
3zok NAD3-dehydroquinate synthase, chloroplastic 4.2.3.4 0.656
1ptj SNDNAD(P) transhydrogenase subunit alpha part 1 1.6.1.2 0.655
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.655
4uun NAIL-lactate dehydrogenase / 0.655
2aa3 AP0L-lactate dehydrogenase / 0.654
1bws NDPGDP-L-fucose synthase / 0.653
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.653
3pfh T3QdTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase 2.1.1.235 0.653
3x2f NAIAdenosylhomocysteinase / 0.653
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.652
2dbz NAPGlyoxylate reductase 1.1.1.26 0.652
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.651
1z0d GDPRas-related protein Rab-5C / 0.650
2yy7 NADL-threonine dehydrogenase / 0.650
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.650
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.650
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.650