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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1phh FAD p-hydroxybenzoate hydroxylase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1phh FADp-hydroxybenzoate hydroxylase / 1.139
3all FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.758
1d7l RFLp-hydroxybenzoate hydroxylase / 0.733
3alm FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.732
4h2n FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.731
4jy2 FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.731
4j2w FADKynurenine 3-monooxygenase / 0.722
5eow FAD6-hydroxynicotinate 3-monooxygenase 1.14.13.114 0.722
1k0j FADp-hydroxybenzoate hydroxylase / 0.719
3gmb FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.715
3cgc FADCoenzyme A disulfide reductase / 0.712
4j34 FADKynurenine 3-monooxygenase / 0.708
4j31 FADKynurenine 3-monooxygenase / 0.704
4k2x FADPolyketide oxygenase/hydroxylase / 0.695
2qa1 FADPgaE / 0.694
3cge FADCoenzyme A disulfide reductase / 0.694
4j33 FADKynurenine 3-monooxygenase / 0.694
2vou FAD2,6-dihydroxypyridine 3-monooxygenase 1.14.13.10 0.691
2e1m FADL-glutamate oxidase / 0.689
1f8w FADNADH peroxidase 1.11.1.1 0.688
4ysh FADGlycine oxidase / 0.687
2a8x FADDihydrolipoyl dehydrogenase 1.8.1.4 0.685
1v59 FADDihydrolipoyl dehydrogenase, mitochondrial 1.8.1.4 0.684
3gsi FADDimethylglycine oxidase 1.5.3.10 0.684
3ic9 FADPutative dihydrolipoamide dehydrogenase / 0.683
2cdu FADNADH oxidase / 0.681
3rp8 FADFAD-dependent urate hydroxylase / 0.681
4h4r FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.681
4h4v FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.681
1ng4 FADGlycine oxidase 1.4.3.19 0.680
4h4p FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
4h4x FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.680
1d7y FADFerredoxin reductase / 0.679
4bk3 FADProbable salicylate monooxygenase / 0.679
1tdk FADL-amino-acid oxidase 1.4.3.2 0.678
2c3d FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.678
3cgd FADCoenzyme A disulfide reductase / 0.678
1xdi FADNAD(P)H dehydrogenase (quinone) / 0.677
1nhp FADNADH peroxidase 1.11.1.1 0.676
2gr0 FADFerredoxin reductase / 0.676
3dh9 FADThioredoxin reductase 1, mitochondrial 1.8.1.9 0.676
4k5r FADOxygenase / 0.676
1nhr FADNADH peroxidase 1.11.1.1 0.675
5er0 FADUncharacterized NAD(FAD)-dependent dehydrogenase / 0.675
1f8s FADL-amino-acid oxidase 1.4.3.2 0.674
1tdo FADL-amino-acid oxidase 1.4.3.2 0.673
3vqr FADPutative oxidoreductase / 0.673
4fx9 FADCoenzyme A disulfide reductase 1.8.1.14 0.673
4hb9 FADUncharacterized protein / 0.672
1c0k FADD-amino-acid oxidase 1.4.3.3 0.671
4fwj FADLysine-specific histone demethylase 1B 1 0.670
3alj FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.668
4bk2 FADProbable salicylate monooxygenase / 0.668
4h4t FADBiphenyl dioxygenase ferredoxin reductase subunit / 0.668
4cy8 FDA2-hydroxybiphenyl-3-monooxygenase / 0.667
4j36 FADKynurenine 3-monooxygenase / 0.667
1nhs FADNADH peroxidase 1.11.1.1 0.665
4bjz FADProbable salicylate monooxygenase / 0.665
1nhq FADNADH peroxidase 1.11.1.1 0.662
2gqw FADFerredoxin reductase / 0.662
2ard FDAFlavin-dependent tryptophan halogenase PrnA 1.14.19.9 0.661
1ebd FADDihydrolipoyl dehydrogenase 1.8.1.4 0.660
2yqu FADDihydrolipoyl dehydrogenase / 0.660
3icr FADCoenzyme A disulfide reductase / 0.660
1ju2 FAD(R)-mandelonitrile lyase 2 4.1.2.10 0.659
2qa2 FADPolyketide oxygenase CabE / 0.659
2qae FADDihydrolipoyl dehydrogenase 1.8.1.4 0.659
4em3 FADCoenzyme A disulfide reductase / 0.659
1ges FADGlutathione reductase 1.8.1.7 0.658
2yr5 FADPhenylalanine 2-monooxygenase precursor 1.13.12.9 0.658
1mok FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.657
2c3c FAD2-oxopropyl-CoM reductase, carboxylating 1.8.1.5 0.657
3fg2 FADPutative rubredoxin reductase / 0.657
4eqs FADCoenzyme A disulfide reductase / 0.657
2xdo FADTetX family tetracycline inactivation enzyme / 0.656
4opl FDAConserved Archaeal protein / 0.654
1c0l FADD-amino-acid oxidase 1.4.3.3 0.653
1zk7 FADMercuric reductase 1.16.1.1 0.653
3cnd FADPolyamine oxidase FMS1 / 0.653
4eqr FADCoenzyme A disulfide reductase / 0.653
4g6g FADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial 1.6.5.9 0.653
5g3s FDAFlavin-dependent L-tryptophan oxidase VioA / 0.653
3oc4 FADOxidoreductase, pyridine nucleotide-disulfide family / 0.652
4m52 FADDihydrolipoyl dehydrogenase 1.8.1.4 0.652
1f3p FADFerredoxin reductase / 0.651
1gox FMNPeroxisomal (S)-2-hydroxy-acid oxidase 1.1.3.15 0.651
1ps9 FAD2,4-dienoyl-CoA reductase 1.3.1.34 0.651
1q1r FADPutidaredoxin reductase 1.18.1.5 0.651
4h2p FAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase / 0.651
4icy FADPgaE / 0.650