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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1hdz NAD Alcohol dehydrogenase 1B 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 1.221
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.005
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.997
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.989
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.987
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.965
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.965
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.962
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.959
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.955
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.953
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.951
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.950
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.950
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.950
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.950
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.949
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.948
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.946
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.945
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.941
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.939
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.935
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.930
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.929
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.917
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.910
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.909
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.902
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.887
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.883
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.880
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.874
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.855
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.852
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.849
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.844
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.837
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.831
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.824
4c4o NADSADH / 0.824
4cpd NADAlcohol dehydrogenase / 0.819
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.817
1yqd NAPSinapyl alcohol dehydrogenase / 0.817
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.799
3two NDPMannitol dehydrogenase / 0.798
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.796
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.792
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.791
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.790
3wle NAD(R)-specific carbonyl reductase / 0.789
4oaq NDPR-specific carbonyl reductase / 0.788
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.787
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.785
4jji NADAlcohol dehydrogenase class-3 / 0.784
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.778
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.777
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.776
2dph NADFormaldehyde dismutase / 0.771
1x7d NADPutative ornithine cyclodeaminase / 0.769
3jv7 NADSecondary alcohol dehydrogenase / 0.769
4l0q NADAlcohol dehydrogenase class-3 / 0.767
1gv0 NADMalate dehydrogenase / 0.764
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.763
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.756
1u7h NADPutative ornithine cyclodeaminase / 0.754
1f8f NADBenzyl alcohol dehydrogenase / 0.753
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.746
4rqu NADAlcohol dehydrogenase class-P / 0.743
1o6z NADMalate dehydrogenase / 0.742
3uko NADAlcohol dehydrogenase class-3 / 0.740
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.734
1yqx NAPSinapyl alcohol dehydrogenase / 0.734
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.733
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.732
4gl4 NAIAlcohol dehydrogenase class-3 / 0.731
1uxk NADMalate dehydrogenase / 0.730
2o4c NADErythronate-4-phosphate dehydrogenase / 0.727
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.726
4ejm NAPPutative zinc-binding dehydrogenase / 0.726
1sow NADL-lactate dehydrogenase 1.1.1.27 0.721
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.717
2xaa NADSecondary alcohol dehydrogenase / 0.717
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.717
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.715
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.713
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.709
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.707
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.706
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.706
2a92 NAIL-lactate dehydrogenase / 0.705
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.705
1uxj NADMalate dehydrogenase / 0.703
2voj NADAlanine dehydrogenase 1.4.1.1 0.703
1ib6 NADMalate dehydrogenase / 0.702
4j43 NADUncharacterized protein / 0.701
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.699
3m2t NADProbable dehydrogenase / 0.697
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.695
3x2f NAIAdenosylhomocysteinase / 0.695
1pzh NADLactate dehydrogenase / 0.692
3abi NADUncharacterized protein / 0.692
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.692
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.691
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.691
1llu NADAlcohol dehydrogenase / 0.690
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.690
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.687
2x0i NAIMalate dehydrogenase / 0.685
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.683
4j4b NAIUncharacterized protein / 0.683
2aa3 AP0L-lactate dehydrogenase / 0.681
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.681
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.681
4b7x NAPProbable oxidoreductase / 0.680
1b8v NADMalate dehydrogenase / 0.678
3ggp NADPrephenate dehydrogenase / 0.673
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.672
2y05 NAPProstaglandin reductase 1 / 0.670
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.670
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.670
2x0r NADMalate dehydrogenase / 0.669
1wzi NDPMalate dehydrogenase / 0.668
2g5c NADPrephenate dehydrogenase / 0.667
1e5q NDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming] 1.5.1.10 0.666
1pzf A3DLactate dehydrogenase / 0.666
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.666
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.665
3wsw NADL-lactate dehydrogenase / 0.665
4xq9 NADHomospermidine synthase 2.5.1.44 0.665
2cda NAPGlucose 1-dehydrogenase / 0.664
3wfj NAD2-dehydropantoate 2-reductase / 0.664
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.664
4xr9 NADCalS8 / 0.664
2dbz NAPGlyoxylate reductase 1.1.1.26 0.662
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.661
4i1i NADMalate dehydrogenase / 0.661
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.661
4ros APRMalate dehydrogenase / 0.661
1wze NADMalate dehydrogenase / 0.660
1c1d NAIPhenylalanine dehydrogenase / 0.659
1guy NADMalate dehydrogenase / 0.659
2hu2 NADC-terminal binding protein 1 / 0.659
4j49 NADUncharacterized protein / 0.659
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.658
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.657
1ie3 NADMalate dehydrogenase / 0.656
2cdc NAPGlucose 1-dehydrogenase / 0.656
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.656
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.656
2dfv NADL-threonine 3-dehydrogenase / 0.655
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.655
4tvb NADHomospermidine synthase 2.5.1.44 0.653
1gq2 NAPNADP-dependent malic enzyme 1.1.1.40 0.652
1up6 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.652
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.652
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.651
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.650
4emi NADToluene 1,2-dioxygenase system ferredoxin--NAD(+) reductase component 1.18.1.3 0.650