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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1h6a NDP Glucose--fructose oxidoreductase 1.1.99.28

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 1.406
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 1.347
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 1.341
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 1.289
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 1.283
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 1.251
5a02 NAPGlucose-fructose oxidoreductase / 1.144
5a03 NDPGlucose-fructose oxidoreductase / 1.116
5a06 NDPGlucose-fructose oxidoreductase / 1.068
5a05 NDPGlucose-fructose oxidoreductase / 1.058
5a04 NDPGlucose-fructose oxidoreductase / 1.050
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 1.024
1rye NDPGlucose--fructose oxidoreductase 1.1.99.28 0.904
1zh8 NAPUncharacterized protein / 0.868
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.823
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.812
2glx NDP1,5-anhydro-D-fructose reductase / 0.766
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.752
1yqd NAPSinapyl alcohol dehydrogenase / 0.741
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.730
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.719
5bsf NADPyrroline-5-carboxylate reductase / 0.707
3rbv NAPSugar 3-ketoreductase / 0.703
4gmg NAPYersiniabactin biosynthetic protein YbtU / 0.702
3ec7 NADInositol 2-dehydrogenase / 0.696
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.695
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.692
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.689
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.688
3wbb NAPMeso-diaminopimelate D-dehydrogenase / 0.687
2f1k NAPPrephenate dehydrogenase / 0.686
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.686
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.681
3m2t NADProbable dehydrogenase / 0.681
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.679
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.679
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.679
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.678
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.678
1dli UDXUDP-glucose 6-dehydrogenase / 0.675
2rcy NAPPyrroline-5-carboxylate reductase / 0.675
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.674
2c29 NAPDihydroflavonol 4-reductase / 0.672
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.672
3aw9 NADNAD-dependent epimerase/dehydratase / 0.670
4kqw NAPKetol-acid reductoisomerase (NADP(+)) / 0.670
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.668
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.668
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.668
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.667
2h63 NAPBiliverdin reductase A 1.3.1.24 0.666
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.666
3tri NAPPyrroline-5-carboxylate reductase / 0.665
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.663
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.662
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
3f3s NADLambda-crystallin homolog / 0.660
4oaq NDPR-specific carbonyl reductase / 0.660
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.659
1lj8 NADMannitol dehydrogenase / 0.658
4xgi NADGlutamate dehydrogenase / 0.658
5bsg NAPPyrroline-5-carboxylate reductase / 0.658
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.657
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.657
1o8c NDPProbable acrylyl-CoA reductase AcuI 1.3.1.84 0.656
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.656
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.656
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.655
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.655
1c1d NAIPhenylalanine dehydrogenase / 0.653
3abi NADUncharacterized protein / 0.653
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.653
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.652
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.652
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.651
2r6h FADNa(+)-translocating NADH-quinone reductase subunit F / 0.651
3i6q NDPPutative leucoanthocyanidin reductase 1 / 0.650
3tnl NADShikimate dehydrogenase (NADP(+)) / 0.650
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.650
3wfj NAD2-dehydropantoate 2-reductase / 0.650
4rf2 NAPNADPH dependent R-specific alcohol dehydrogenase / 0.650