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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1gjv AGS [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 1.035
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.870
3sl2 ATPSensor histidine kinase WalK / 0.861
3a0t ADPSensor histidine kinase / 0.851
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.839
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.828
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.783
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.778
4wud ANPDNA gyrase subunit B / 0.765
1nhh ANPDNA mismatch repair protein MutL / 0.759
4wuc ANPDNA gyrase subunit B / 0.753
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.751
4prv ADPDNA gyrase subunit B / 0.749
1i5a ACPChemotaxis protein CheA 2.7.13.3 0.745
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.745
4biw ANPSensor histidine kinase CpxA / 0.743
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.742
4prx ADPDNA gyrase subunit B / 0.742
3t2s AGSHeat shock protein HSP 90-alpha / 0.737
2zdy ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.736
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.735
4ivg ANPTNF receptor-associated protein 1 / 0.732
1i5b ANPChemotaxis protein CheA 2.7.13.3 0.730
1byq ADPHeat shock protein HSP 90-alpha / 0.723
2c2a ADPSensor histidine kinase / 0.719
1thn ADPAnti-sigma F factor / 0.718
1til ATPAnti-sigma F factor / 0.713
2yef ANPHeat shock protein HSP 90-alpha / 0.713
2xcm ADPCytosolic heat shock protein 90 / 0.711
3h4l ANPDNA mismatch repair protein PMS1 / 0.704
4gqt ADPHeat shock protein 90 / 0.702
4biz ADPSensor histidine kinase CpxA / 0.692
3t1k ANPHeat shock protein HSP 90-alpha / 0.691
4bix ADPSensor histidine kinase CpxA / 0.688
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.688
1th8 ADPAnti-sigma F factor / 0.687
4ipe ANPTNF receptor-associated protein 1 / 0.687
4xc0 ACPHeat shock cognate 90 kDa protein / 0.687
4xcj ADPHeat shock cognate 90 kDa protein / 0.681
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.677
1id0 ANPSensor protein PhoQ 2.7.13.3 0.674
4xcl AGSHeat shock cognate 90 kDa protein / 0.674
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.673
5c93 ACPTwo-component system histidine protein kinase / 0.666
1jsc TPPAcetolactate synthase catalytic subunit, mitochondrial 2.2.1.6 0.664
3t0z ATPHeat shock protein HSP 90-alpha / 0.664
2bu8 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.663
4gt8 ADPSensor protein VraS 2.7.13.3 0.663
3t10 ACPHeat shock protein HSP 90-alpha / 0.662
4pl9 ADPEthylene receptor 1 / 0.662
4xfj ANPArgininosuccinate synthase / 0.662
2ior ADPChaperone protein HtpG / 0.658
3hdy GDUUDP-galactopyranose mutase / 0.657
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.654
4fj5 DTPDNA-directed DNA polymerase / 0.654
1lol XMPOrotidine 5'-phosphate decarboxylase 4.1.1.23 0.653
1l0o ADPAnti-sigma F factor / 0.652
3dge ADPSensor histidine kinase / 0.650