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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1e3k R18 Progesterone receptor

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1e3k R18Progesterone receptor / 1.030
1xow R18Androgen receptor / 0.762
1n38 U3HRNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2cgw 3C3Serine/threonine-protein kinase Chk1 2.7.11.1 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
2oap ANPType II secretion system protein (GspE-2) / 0.744
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.744
2zs9 ADPPantothenate kinase 2.7.1.33 0.744
3cwq ADPParA family chromosome partitioning protein / 0.744
3f8p NADNADH oxidase/thioredoxin reductase / 0.744
3fzf ATPHeat shock cognate 71 kDa protein / 0.744
3u9d ATPActin, alpha skeletal muscle / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.744
1xq3 R18Androgen receptor / 0.737
2amb 17HAndrogen receptor / 0.737
3vhu SNLMineralocorticoid receptor / 0.734
4ofu DHTAndrogen receptor / 0.733
1e3g R18Androgen receptor / 0.723
4oed DHTAndrogen receptor / 0.710
2ao6 R18Androgen receptor / 0.700
4oey DHTAndrogen receptor / 0.699
2am9 TESAndrogen receptor / 0.688
4ofr DHTAndrogen receptor / 0.686
1t79 DHTAndrogen receptor / 0.685
2oax SNLMineralocorticoid receptor / 0.684
2q7l TESAndrogen receptor / 0.684
2yhd TESAndrogen receptor / 0.684
1t7t DHTAndrogen receptor / 0.681
4oez DHTAndrogen receptor / 0.678
2pip DHTAndrogen receptor / 0.671
4c49 HCYCorticosteroid-binding globulin / 0.671
2ylq TESAndrogen receptor / 0.667
1t73 DHTAndrogen receptor / 0.662
2piu DHTAndrogen receptor / 0.662
2ylp TESAndrogen receptor / 0.661
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.660
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1yra GDPGPN-loop GTPase PAB0955 / 0.660
2hru ADPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2hs4 ACPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.660
4cdg ADPBloom syndrome protein 3.6.4.12 0.660
4nxv GDPMitochondrial dynamics protein MID51 / 0.660
1t76 DHTAndrogen receptor / 0.656
3uzz ASD3-oxo-5-beta-steroid 4-dehydrogenase / 0.653
1t63 DHTAndrogen receptor / 0.652
2aa7 1CAMineralocorticoid receptor / 0.652
2q7j TESAndrogen receptor / 0.652
1t7f DHTAndrogen receptor / 0.651