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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1cdk ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.217
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.200
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.169
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.168
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.166
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.132
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.111
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.068
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.063
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.061
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.061
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.058
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 1.048
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.006
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.995
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.953
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.951
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.941
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.935
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.907
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.888
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.876
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.868
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.865
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.865
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.864
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.830
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.827
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.817
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.817
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.814
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.800
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.792
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.784
4ysj ADPCalmodulin-like domain protein kinase / 0.779
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.776
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.768
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.768
3orm AGSSerine/threonine protein kinase / 0.760
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.757
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.756
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.755
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.754
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.753
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.753
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.750
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.747
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.747
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.746
5byl GCPBifunctional AAC/APH 2.3.1 0.746
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.744
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.744
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.744
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.742
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.741
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.740
1m0w ANPGlutathione synthetase 6.3.2.3 0.739
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.739
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.739
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.738
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.737
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.737
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.735
3c4z ADPRhodopsin kinase / 0.733
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.733
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.732
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.732
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.732
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.732
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.730
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.728
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.727
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.727
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.727
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.726
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.726
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.726
3ori AGSSerine/threonine protein kinase / 0.725
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.724
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.724
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.724
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.722
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.722
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.719
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.718
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.718
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.717
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.717
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.715
4qny ANPMitogen activated protein kinase, putative / 0.715
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.713
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.713
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.712
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.712
1mq4 ADPAurora kinase A 2.7.11.1 0.710
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.710
5dn3 ATPAurora kinase A 2.7.11.1 0.710
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.708
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.707
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.706
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.702
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.699
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.699
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.699
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.698
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.698
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.697
5dr2 ATPAurora kinase A 2.7.11.1 0.696
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.695
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.695
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.695
3ort AGSSerine/threonine protein kinase / 0.695
3c50 ADPRhodopsin kinase / 0.694
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.694
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.693
4ceg ADPAurora kinase A 2.7.11.1 0.693
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.692
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.691
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.691
2pul ACPMethylthioribose kinase 2.7.1.100 0.690
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.690
4dee ADPAurora kinase A 2.7.11.1 0.690
5dt3 ATPAurora kinase A 2.7.11.1 0.690
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.689
2pup ADPMethylthioribose kinase 2.7.1.100 0.688
2x0q ATPAlcaligin biosynthesis protein / 0.688
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.687
4n57 ADPAPH(2'')-Id / 0.687
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.686
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.686
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.686
3lmi ATPMyosin heavy chain kinase A 2.7.11.7 0.686
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.686
5dos ATPAurora kinase A 2.7.11.1 0.686
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.685
2pml ANPUncharacterized protein / 0.685
2pyw ADPMethylthioribose kinase 2.7.1.100 0.685
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.684
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.684
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.683
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.683
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.683
3c4w ATPRhodopsin kinase / 0.681
3t8o ATPRhodopsin kinase / 0.680
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.680
5ce3 ADPProtein kinase YopO / 0.680
4o4d ATPKinase / 0.679
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.678
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.676
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.676
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
5ckw ANPUncharacterized protein / 0.674
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.673
3qc9 ADPRhodopsin kinase / 0.673
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.673
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.672
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.672
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.672
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.671
5csh ATPCasein kinase II subunit alpha 2.7.11.1 0.671
1dv2 ATPBiotin carboxylase 6.3.4.14 0.669
3nie ANPMitogen-activated protein kinase / 0.669
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.669
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.669
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.668
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.668
5iqb GNPBifunctional AAC/APH 2.3.1 0.668
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.666
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.666
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.666
4ork GDPBifunctional AAC/APH 2.3.1 0.665
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.665
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.665
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.665
2wqe ADPAurora kinase A 2.7.11.1 0.664
5drd ATPAurora kinase A 2.7.11.1 0.663
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.662
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.662
3wnz ADPAlanine--anticapsin ligase / 0.660
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.658
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.658
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.658
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.658
4xlv ACPInsulin receptor 2.7.10.1 0.658
2pun ACPMethylthioribose kinase 2.7.1.100 0.656
2yaa ATPDeath-associated protein kinase 2 / 0.656
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.656
4uhr NGIAdenosine receptor A2a / 0.656
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.655
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.655
4ffr ATPUncharacterized protein / 0.655
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.655
5cu6 ATPCasein kinase II subunit alpha 2.7.11.1 0.655
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.654
2eh4 SAHDiphthine synthase / 0.654
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.654
1cm8 ANPMitogen-activated protein kinase 12 / 0.653
3rv4 ADPBiotin carboxylase 6.3.4.14 0.653
5dnr ATPAurora kinase A 2.7.11.1 0.653
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.652
3oii SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.652
5iqf GDPBifunctional AAC/APH 2.3.1 0.652
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.651
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.651
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.651
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.650
4q5h ANPProtein kinase OspG 2.7 0.650