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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4fx360KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4fx360KCyclin-dependent kinase 22.7.11.221.000
1fvv107Cyclin-dependent kinase 22.7.11.220.549
1gih1PUCyclin-dependent kinase 22.7.11.220.542
2wxvWXVCyclin-dependent kinase 22.7.11.220.538
3ral04ZCyclin-dependent kinase 22.7.11.220.531
3rmf20ZCyclin-dependent kinase 22.7.11.220.528
3qqkX02Cyclin-dependent kinase 22.7.11.220.525
1p2a5BNCyclin-dependent kinase 22.7.11.220.521
2wpa889Cyclin-dependent kinase 22.7.11.220.521
3rak03ZCyclin-dependent kinase 22.7.11.220.520
2btsU32Cyclin-dependent kinase 22.7.11.220.517
4fkw62KCyclin-dependent kinase 22.7.11.220.515
4bgh3I6Cyclin-dependent kinase 22.7.11.220.509
3sqq99ZCyclin-dependent kinase 22.7.11.220.508
4bcnT9NCyclin-dependent kinase 22.7.11.220.508
2w05FRTCyclin-dependent kinase 22.7.11.220.507
4fkr45KCyclin-dependent kinase 22.7.11.220.506
1pkdUCNCyclin-dependent kinase 22.7.11.220.505
3qtxX43Cyclin-dependent kinase 22.7.11.220.505
3r9dX6BCyclin-dependent kinase 22.7.11.220.505
3s1h56ZCyclin-dependent kinase 22.7.11.220.505
3rpv26ZCyclin-dependent kinase 22.7.11.220.503
3s2pPMUCyclin-dependent kinase 22.7.11.220.502
1dm2HMDCyclin-dependent kinase 22.7.11.220.501
2btrU73Cyclin-dependent kinase 22.7.11.220.500
3qtzX42Cyclin-dependent kinase 22.7.11.220.499
3qu0X40Cyclin-dependent kinase 22.7.11.220.499
3rk708ZCyclin-dependent kinase 22.7.11.220.496
3rk507ZCyclin-dependent kinase 22.7.11.220.495
1oguST8Cyclin-dependent kinase 22.7.11.220.494
1vyw292Cyclin-dependent kinase 22.7.11.220.493
1w0xOLOCyclin-dependent kinase 22.7.11.220.493
2c6iDT1Cyclin-dependent kinase 22.7.11.220.493
3tnwF18Cyclin-dependent kinase 22.7.11.220.493
3r9hZ67Cyclin-dependent kinase 22.7.11.220.492
3rjc06ZCyclin-dependent kinase 22.7.11.220.492
3rni21ZCyclin-dependent kinase 22.7.11.220.491
1v1k3FPCyclin-dependent kinase 22.7.11.220.490
4fkt48KCyclin-dependent kinase 22.7.11.220.490
1pyePM1Cyclin-dependent kinase 22.7.11.220.489
2wihP48Cyclin-dependent kinase 22.7.11.220.489
1urwI1PCyclin-dependent kinase 22.7.11.220.487
3rk909ZCyclin-dependent kinase 22.7.11.220.487
1finATPCyclin-dependent kinase 22.7.11.220.485
1ke6LS2Cyclin-dependent kinase 22.7.11.220.485
1ke9LS5Cyclin-dependent kinase 22.7.11.220.485
2iw84SPCyclin-dependent kinase 22.7.11.220.484
4fkv61KCyclin-dependent kinase 22.7.11.220.484
1e9hINRCyclin-dependent kinase 22.7.11.220.483
1ke5LS1Cyclin-dependent kinase 22.7.11.220.483
2xmyCDKCyclin-dependent kinase 22.7.11.220.483
1ckpPVBCyclin-dependent kinase 22.7.11.220.482
2vv9IM9Cyclin-dependent kinase 22.7.11.220.482
3qtqX35Cyclin-dependent kinase 22.7.11.220.482
3unk0BYCyclin-dependent kinase 22.7.11.220.482
2b52D42Cyclin-dependent kinase 22.7.11.220.481
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.481
2i40BLZCyclin-dependent kinase 22.7.11.220.480
3qxoX65Cyclin-dependent kinase 22.7.11.220.480
1oitHDTCyclin-dependent kinase 22.7.11.220.479
3lfsA07Cyclin-dependent kinase 22.7.11.220.479
3qtuX44Cyclin-dependent kinase 22.7.11.220.479
2w06FRVCyclin-dependent kinase 22.7.11.220.478
3qzgX67Cyclin-dependent kinase 22.7.11.220.478
2j9mPY8Cyclin-dependent kinase 22.7.11.220.477
2uzbC75Cyclin-dependent kinase 22.7.11.220.477
3ig7EFPCyclin-dependent kinase 22.7.11.220.477
1ke7LS3Cyclin-dependent kinase 22.7.11.220.476
1pxmCK5Cyclin-dependent kinase 22.7.11.220.476
1pxoCK7Cyclin-dependent kinase 22.7.11.220.476
4fkpLS5Cyclin-dependent kinase 22.7.11.220.476
1h1r6CPCyclin-dependent kinase 22.7.11.220.474
1oiyN41Cyclin-dependent kinase 22.7.11.220.474
2r3kSCQCyclin-dependent kinase 22.7.11.220.474
3ddqRRCCyclin-dependent kinase 22.7.11.220.474
4nj32KDCyclin-dependent kinase 22.7.11.220.474
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.473
4eop1ROCyclin-dependent kinase 22.7.11.220.473
1di8DTQCyclin-dependent kinase 22.7.11.220.472
4acm7YGCyclin-dependent kinase 22.7.11.220.471
1oiqHDUCyclin-dependent kinase 22.7.11.220.470
2iw94SPCyclin-dependent kinase 22.7.11.220.470
3qtrX36Cyclin-dependent kinase 22.7.11.220.470
1g5sI17Cyclin-dependent kinase 22.7.11.220.468
1vyzN5BCyclin-dependent kinase 22.7.11.220.468
2r3p3SCCyclin-dependent kinase 22.7.11.220.468
2uzdC85Cyclin-dependent kinase 22.7.11.220.468
3bhtMFRCyclin-dependent kinase 22.7.11.220.468
3uli1N3Cyclin-dependent kinase 22.7.11.220.468
4eomATPCyclin-dependent kinase 22.7.11.220.468
4fkg4CKCyclin-dependent kinase 22.7.11.220.468
1h1s4SPCyclin-dependent kinase 22.7.11.220.467
2fvdLIACyclin-dependent kinase 22.7.11.220.467
2r3r6SCCyclin-dependent kinase 22.7.11.220.467
3my5RFZCyclin-dependent kinase 22.7.11.220.467
4ek610KCyclin-dependent kinase 22.7.11.220.467
1ke8LS4Cyclin-dependent kinase 22.7.11.220.466
1y91CT9Cyclin-dependent kinase 22.7.11.220.466
2c5nCK8Cyclin-dependent kinase 22.7.11.220.466
2cchATPCyclin-dependent kinase 22.7.11.220.466
3r73X87Cyclin-dependent kinase 22.7.11.220.466
4ek816KCyclin-dependent kinase 22.7.11.220.466
4eok4SPCyclin-dependent kinase 22.7.11.220.466
1fvt106Cyclin-dependent kinase 22.7.11.220.465
2r3lSCWCyclin-dependent kinase 22.7.11.220.465
3rm719ZCyclin-dependent kinase 22.7.11.220.465
4qmpDKISerine/threonine-protein kinase 242.7.11.10.465
2c6o4SPCyclin-dependent kinase 22.7.11.220.464
3sw418KCyclin-dependent kinase 22.7.11.220.464
2vu3LZECyclin-dependent kinase 22.7.11.220.463
3qqfX07Cyclin-dependent kinase 22.7.11.220.463
3rkb12ZCyclin-dependent kinase 22.7.11.220.463
3ezvEZVCyclin-dependent kinase 22.7.11.220.462
3fz1B98Cyclin-dependent kinase 22.7.11.220.462
3qwjX6ACyclin-dependent kinase 22.7.11.220.462
4eos1ROCyclin-dependent kinase 22.7.11.220.462
2bheBRYCyclin-dependent kinase 22.7.11.220.461
2eufLQQCyclin-dependent kinase 62.7.11.220.461
1oi9N20Cyclin-dependent kinase 22.7.11.220.460
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.460
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.460
3s0o50ZCyclin-dependent kinase 22.7.11.220.460
3qzfX66Cyclin-dependent kinase 22.7.11.220.459
3rpy27ZCyclin-dependent kinase 22.7.11.220.459
3roy22ZCyclin-dependent kinase 22.7.11.220.457
4bcpT3CCyclin-dependent kinase 22.7.11.220.457
1aq1STUCyclin-dependent kinase 22.7.11.220.456
2a0cCK9Cyclin-dependent kinase 22.7.11.220.456
2w1hL0FCyclin-dependent kinase 22.7.11.220.456
3ddpRC8Cyclin-dependent kinase 22.7.11.220.456
3r8zZ63Cyclin-dependent kinase 22.7.11.220.456
3ti1B49Cyclin-dependent kinase 22.7.11.220.456
2r3o2SCCyclin-dependent kinase 22.7.11.220.455
3py0SU9Cyclin-dependent kinase 22.7.11.220.455
3r7iX9ICyclin-dependent kinase 22.7.11.220.455
2bhhRYUCyclin-dependent kinase 22.7.11.220.454
2uzoC62Cyclin-dependent kinase 22.7.11.220.454
3lfnA27Cyclin-dependent kinase 22.7.11.220.454
4fks46KCyclin-dependent kinase 22.7.11.220.454
4fko20KCyclin-dependent kinase 22.7.11.220.453
1h0w207Cyclin-dependent kinase 22.7.11.220.452
3r9oZ71Cyclin-dependent kinase 22.7.11.220.452
4ez30S0Cyclin-dependent kinase 22.7.11.220.452
2vthLZ2Cyclin-dependent kinase 22.7.11.220.451
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.451
2r3iSCFCyclin-dependent kinase 22.7.11.220.450
2r64740Cyclin-dependent kinase 22.7.11.220.450
2x1nX1NCyclin-dependent kinase 22.7.11.220.450
4eoi1ROCyclin-dependent kinase 22.7.11.220.450
1qmzATPCyclin-dependent kinase 22.7.11.220.449
3dogNNNCyclin-dependent kinase 22.7.11.220.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
2b55D31Cyclin-dependent kinase 22.7.11.220.448
2vttLZDCyclin-dependent kinase 22.7.11.220.448
3iggEFQCyclin-dependent kinase 22.7.11.220.448
3qtwX3ACyclin-dependent kinase 22.7.11.220.448
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.448
2c69CT8Cyclin-dependent kinase 22.7.11.220.446
2vtsLZCCyclin-dependent kinase 22.7.11.220.446
2xnbY8LCyclin-dependent kinase 22.7.11.220.446
3qzhX69Cyclin-dependent kinase 22.7.11.220.446
3r7uX96Cyclin-dependent kinase 22.7.11.220.446
4eon1ROCyclin-dependent kinase 22.7.11.220.446
4fki09KCyclin-dependent kinase 22.7.11.220.446
4fkq42KCyclin-dependent kinase 22.7.11.220.446
2c6tDT5Cyclin-dependent kinase 22.7.11.220.445
3raiX85Cyclin-dependent kinase 22.7.11.220.445
4lyn1YGCyclin-dependent kinase 22.7.11.220.445
1pxkCK3Cyclin-dependent kinase 22.7.11.220.444
2r3mSCXCyclin-dependent kinase 22.7.11.220.444
2uznC96Cyclin-dependent kinase 22.7.11.220.444
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.444
3lfqA28Cyclin-dependent kinase 22.7.11.220.444
3r71X86Cyclin-dependent kinase 22.7.11.220.444
3sw719KCyclin-dependent kinase 22.7.11.220.444
4eol1ROCyclin-dependent kinase 22.7.11.220.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.443
3rpo24ZCyclin-dependent kinase 22.7.11.220.443
2uzlC94Cyclin-dependent kinase 22.7.11.220.441
2bkzSBCCyclin-dependent kinase 22.7.11.220.440
3r7yZ04Cyclin-dependent kinase 22.7.11.220.440
3unj0BXCyclin-dependent kinase 22.7.11.220.440
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.440
4qmySTUSerine/threonine-protein kinase 242.7.11.10.440