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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4ek610KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4ek610KCyclin-dependent kinase 22.7.11.221.000
4fkg4CKCyclin-dependent kinase 22.7.11.220.635
4fkt48KCyclin-dependent kinase 22.7.11.220.609
1ykr628Cyclin-dependent kinase 22.7.11.220.592
2a0cCK9Cyclin-dependent kinase 22.7.11.220.559
4fki09KCyclin-dependent kinase 22.7.11.220.558
1pxmCK5Cyclin-dependent kinase 22.7.11.220.557
2btrU73Cyclin-dependent kinase 22.7.11.220.554
1pxlCK4Cyclin-dependent kinase 22.7.11.220.553
2vthLZ2Cyclin-dependent kinase 22.7.11.220.552
4fkpLS5Cyclin-dependent kinase 22.7.11.220.551
1oitHDTCyclin-dependent kinase 22.7.11.220.550
3rni21ZCyclin-dependent kinase 22.7.11.220.549
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.547
3s2pPMUCyclin-dependent kinase 22.7.11.220.544
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.543
4ek816KCyclin-dependent kinase 22.7.11.220.541
1ke5LS1Cyclin-dependent kinase 22.7.11.220.540
3lfqA28Cyclin-dependent kinase 22.7.11.220.537
3r8lZ30Cyclin-dependent kinase 22.7.11.220.537
2c6o4SPCyclin-dependent kinase 22.7.11.220.532
3lfnA27Cyclin-dependent kinase 22.7.11.220.528
3r7uX96Cyclin-dependent kinase 22.7.11.220.527
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.522
3r1yX76Cyclin-dependent kinase 22.7.11.220.519
1w0xOLOCyclin-dependent kinase 22.7.11.220.512
3qzgX67Cyclin-dependent kinase 22.7.11.220.512
4fkq42KCyclin-dependent kinase 22.7.11.220.512
1w8cN69Cyclin-dependent kinase 22.7.11.220.510
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.510
3qxoX65Cyclin-dependent kinase 22.7.11.220.508
1g5sI17Cyclin-dependent kinase 22.7.11.220.507
2xmyCDKCyclin-dependent kinase 22.7.11.220.507
3rk708ZCyclin-dependent kinase 22.7.11.220.507
3sqq99ZCyclin-dependent kinase 22.7.11.220.506
4fklCK2Cyclin-dependent kinase 22.7.11.220.506
2btsU32Cyclin-dependent kinase 22.7.11.220.505
2a4lRRCCyclin-dependent kinase 22.7.11.220.504
4fkj11KCyclin-dependent kinase 22.7.11.220.504
3lfsA07Cyclin-dependent kinase 22.7.11.220.503
1vyzN5BCyclin-dependent kinase 22.7.11.220.502
1aq1STUCyclin-dependent kinase 22.7.11.220.501
1oirHDYCyclin-dependent kinase 22.7.11.220.501
1pxoCK7Cyclin-dependent kinase 22.7.11.220.501
2r3iSCFCyclin-dependent kinase 22.7.11.220.498
3r73X87Cyclin-dependent kinase 22.7.11.220.495
2uzoC62Cyclin-dependent kinase 22.7.11.220.494
3rm719ZCyclin-dependent kinase 22.7.11.220.494
1ke7LS3Cyclin-dependent kinase 22.7.11.220.493
3rk909ZCyclin-dependent kinase 22.7.11.220.493
1ke6LS2Cyclin-dependent kinase 22.7.11.220.491
3qqlX03Cyclin-dependent kinase 22.7.11.220.491
3r7vZ02Cyclin-dependent kinase 22.7.11.220.491
3rpo24ZCyclin-dependent kinase 22.7.11.220.491
2bhhRYUCyclin-dependent kinase 22.7.11.220.490
1gih1PUCyclin-dependent kinase 22.7.11.220.489
2r3lSCWCyclin-dependent kinase 22.7.11.220.489
1y91CT9Cyclin-dependent kinase 22.7.11.220.488
1ckpPVBCyclin-dependent kinase 22.7.11.220.487
2r64740Cyclin-dependent kinase 22.7.11.220.487
3r7yZ04Cyclin-dependent kinase 22.7.11.220.487
3qqkX02Cyclin-dependent kinase 22.7.11.220.486
1v1k3FPCyclin-dependent kinase 22.7.11.220.485
1y8yCT7Cyclin-dependent kinase 22.7.11.220.485
2b52D42Cyclin-dependent kinase 22.7.11.220.485
2r3r6SCCyclin-dependent kinase 22.7.11.220.485
3qqfX07Cyclin-dependent kinase 22.7.11.220.485
2r3jSCJCyclin-dependent kinase 22.7.11.220.484
3rjc06ZCyclin-dependent kinase 22.7.11.220.484
4bgh3I6Cyclin-dependent kinase 22.7.11.220.484
2r3p3SCCyclin-dependent kinase 22.7.11.220.483
4ez30S0Cyclin-dependent kinase 22.7.11.220.483
3r9dX6BCyclin-dependent kinase 22.7.11.220.482
1h0w207Cyclin-dependent kinase 22.7.11.220.480
3r71X86Cyclin-dependent kinase 22.7.11.220.480
4fkr45KCyclin-dependent kinase 22.7.11.220.480
4nj32KDCyclin-dependent kinase 22.7.11.220.480
1ke9LS5Cyclin-dependent kinase 22.7.11.220.479
3fz1B98Cyclin-dependent kinase 22.7.11.220.479
3qu0X40Cyclin-dependent kinase 22.7.11.220.479
1p2a5BNCyclin-dependent kinase 22.7.11.220.478
1e1xNW1Cyclin-dependent kinase 22.7.11.220.477
3r8vZ62Cyclin-dependent kinase 22.7.11.220.477
4fks46KCyclin-dependent kinase 22.7.11.220.477
2c6lDT4Cyclin-dependent kinase 22.7.11.220.476
3qtzX42Cyclin-dependent kinase 22.7.11.220.476
3r83Z14Cyclin-dependent kinase 22.7.11.220.476
3qwjX6ACyclin-dependent kinase 22.7.11.220.475
1gii1PUCyclin-dependent kinase 22.7.11.220.474
1pyePM1Cyclin-dependent kinase 22.7.11.220.474
3nynSGVG protein-coupled receptor kinase 62.7.11.160.474
2c6kDT2Cyclin-dependent kinase 22.7.11.220.473
2exmZIPCyclin-dependent kinase 22.7.11.220.473
3qtxX43Cyclin-dependent kinase 22.7.11.220.473
3qtuX44Cyclin-dependent kinase 22.7.11.220.472
3r1sX73Cyclin-dependent kinase 22.7.11.220.472
4erwSTUCyclin-dependent kinase 22.7.11.220.472
1b38ATPCyclin-dependent kinase 22.7.11.220.471
2b53D23Cyclin-dependent kinase 22.7.11.220.471
3rmf20ZCyclin-dependent kinase 22.7.11.220.471
3ezvEZVCyclin-dependent kinase 22.7.11.220.470
2vtsLZCCyclin-dependent kinase 22.7.11.220.469
2w1hL0FCyclin-dependent kinase 22.7.11.220.469
3qqhX0ACyclin-dependent kinase 22.7.11.220.469
3rm618ZCyclin-dependent kinase 22.7.11.220.468
4fkv61KCyclin-dependent kinase 22.7.11.220.468
1b39ATPCyclin-dependent kinase 22.7.11.220.467
1pxkCK3Cyclin-dependent kinase 22.7.11.220.467
1pxpCK8Cyclin-dependent kinase 22.7.11.220.466
3r6xX84Cyclin-dependent kinase 22.7.11.220.466
1dm2HMDCyclin-dependent kinase 22.7.11.220.465
3qzhX69Cyclin-dependent kinase 22.7.11.220.465
3roy22ZCyclin-dependent kinase 22.7.11.220.465
3pxyJWSCyclin-dependent kinase 22.7.11.220.461
2c6iDT1Cyclin-dependent kinase 22.7.11.220.460
3raiX85Cyclin-dependent kinase 22.7.11.220.460
3rpy27ZCyclin-dependent kinase 22.7.11.220.460
1fvt106Cyclin-dependent kinase 22.7.11.220.459
2duv371Cyclin-dependent kinase 22.7.11.220.459
3s1h56ZCyclin-dependent kinase 22.7.11.220.459
1urwI1PCyclin-dependent kinase 22.7.11.220.458
3rpv26ZCyclin-dependent kinase 22.7.11.220.458
2w06FRVCyclin-dependent kinase 22.7.11.220.457
3iggEFQCyclin-dependent kinase 22.7.11.220.457
2uznC96Cyclin-dependent kinase 22.7.11.220.456
3r7iX9ICyclin-dependent kinase 22.7.11.220.456
3s0o50ZCyclin-dependent kinase 22.7.11.220.455
3unk0BYCyclin-dependent kinase 22.7.11.220.455
3ral04ZCyclin-dependent kinase 22.7.11.220.454
4fko20KCyclin-dependent kinase 22.7.11.220.453
3ddpRC8Cyclin-dependent kinase 22.7.11.220.451
3r28XA0Cyclin-dependent kinase 22.7.11.220.451
3sw719KCyclin-dependent kinase 22.7.11.220.451
4fkw62KCyclin-dependent kinase 22.7.11.220.451
2vv9IM9Cyclin-dependent kinase 22.7.11.220.450
3ezrEZRCyclin-dependent kinase 22.7.11.220.450
1h1s4SPCyclin-dependent kinase 22.7.11.220.449
1oguST8Cyclin-dependent kinase 22.7.11.220.448
2w17I19Cyclin-dependent kinase 22.7.11.220.448
3wblPDYCyclin-dependent kinase 22.7.11.220.448
2bheBRYCyclin-dependent kinase 22.7.11.220.447
3rk507ZCyclin-dependent kinase 22.7.11.220.447
3r8pZ46Cyclin-dependent kinase 22.7.11.220.446
3qzfX66Cyclin-dependent kinase 22.7.11.220.445
2b55D31Cyclin-dependent kinase 22.7.11.220.444
3r7eX88Cyclin-dependent kinase 22.7.11.220.442
4lyn1YGCyclin-dependent kinase 22.7.11.220.442