sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hv3 | R49 | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.646 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.614 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.589 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.565 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.565 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.549 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.517 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.500 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.499 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.484 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.479 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.479 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.478 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.477 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 2wjo | QUD | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.473 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.472 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.471 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.469 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.467 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3ppk | FNI | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.465 | |
| 4eyj | N61 | Mitogen-activated protein kinase 13 | 2.7.11.24 | 0.465 | |
| 1x7g | NAP | Putative ketoacyl reductase | 1.3.1 | 0.464 | |
| 3ns2 | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3huc | G97 | Mitogen-activated protein kinase 14 | / | 0.460 | |
| 4g31 | 0WH | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.459 | |
| 3rtn | RTN | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 5dp2 | NAP | CurF | / | 0.458 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.457 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.457 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.455 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.453 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.452 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.452 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.452 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.451 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.451 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.449 | |
| 4g34 | 924 | Eukaryotic translation initiation factor 2-alpha kinase 3 | 2.7.11.1 | 0.449 | |
| 1efz | PRF | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.448 | |
| 1eqb | FFO | Serine hydroxymethyltransferase | 2.1.2.1 | 0.448 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.448 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.447 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.446 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.446 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.446 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.444 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.444 | |
| 4l8u | 9AZ | Serum albumin | / | 0.444 | |
| 5bt4 | 2LO | Bromodomain-containing protein 4 | / | 0.444 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 2wd8 | VGF | Pteridine reductase | / | 0.443 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.443 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.443 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 2bxo | OPB | Serum albumin | / | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.442 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 1rfq | LAR | Actin, alpha skeletal muscle | / | 0.441 | |
| 1syn | F89 | Thymidylate synthase | / | 0.441 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.440 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 3vjc | ZGA | Squalene synthase | 2.5.1.21 | 0.440 |