sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3gcq | 1BU | Mitogen-activated protein kinase 14 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 1.000 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.617 | |
| 3lfc | Z86 | Mitogen-activated protein kinase 14 | / | 0.602 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.535 | |
| 3l8s | BFF | Mitogen-activated protein kinase 14 | / | 0.525 | |
| 3iw8 | HIZ | Mitogen-activated protein kinase 14 | / | 0.516 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.514 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.510 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.489 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.488 | |
| 3ctj | 320 | Hepatocyte growth factor receptor | 2.7.10.1 | 0.483 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.480 | |
| 3itz | P66 | Mitogen-activated protein kinase 14 | / | 0.478 | |
| 4eyj | N61 | Mitogen-activated protein kinase 13 | 2.7.11.24 | 0.478 | |
| 1w83 | L11 | Mitogen-activated protein kinase 14 | / | 0.477 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.476 | |
| 1w7h | 3IP | Mitogen-activated protein kinase 14 | / | 0.468 | |
| 4eh6 | 0ON | Mitogen-activated protein kinase 14 | / | 0.467 | |
| 2uxh | QUE | HTH-type transcriptional regulator TtgR | / | 0.466 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.466 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.463 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.463 | |
| 3l9m | L9M | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.461 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.461 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.460 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.460 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.458 | |
| 2zb1 | GK4 | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.456 | |
| 2yvw | EPU | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.456 | |
| 3p9t | TCL | Repressor | / | 0.456 | |
| 3ds6 | A17 | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.453 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.452 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.451 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.451 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.450 | |
| 3be2 | RAJ | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.449 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.448 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.447 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.447 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.447 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.446 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.444 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.444 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.443 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.443 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.443 | |
| 4equ | G6I | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.443 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.443 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.442 | |
| 3ngl | NAP | Bifunctional protein FolD | / | 0.442 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.442 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.441 | |
| 3nxo | D2B | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4a4o | 664 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.440 |