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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3dcsMZMCarbonic anhydrase 24.2.1.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3dcsMZMCarbonic anhydrase 24.2.1.11.000
3dc3AZMCarbonic anhydrase 24.2.1.10.763
4kap1QVCarbonic anhydrase 24.2.1.10.701
4m2rBZ1Carbonic anhydrase 24.2.1.10.683
1if5FBTCarbonic anhydrase 24.2.1.10.682
3hkuTORCarbonic anhydrase 24.2.1.10.681
1if6FBUCarbonic anhydrase 24.2.1.10.670
3qykIE2Carbonic anhydrase 24.2.1.10.665
2x7tWZBCarbonic anhydrase 24.2.1.10.647
1if7SBRCarbonic anhydrase 24.2.1.10.636
3m5eJDRCarbonic anhydrase 24.2.1.10.636
1bn3AL6Carbonic anhydrase 24.2.1.10.628
4m2vBZ1Carbonic anhydrase 24.2.1.10.627
1i91INQCarbonic anhydrase 24.2.1.10.626
1bnnAL1Carbonic anhydrase 24.2.1.10.624
2h15B19Carbonic anhydrase 24.2.1.10.624
1bn1AL5Carbonic anhydrase 24.2.1.10.621
1g52F2BCarbonic anhydrase 24.2.1.10.621
1i9qIOFCarbonic anhydrase 24.2.1.10.621
3d9zD9ZCarbonic anhydrase 24.2.1.10.618
1g45FSBCarbonic anhydrase 24.2.1.10.617
3t82SG4Carbonic anhydrase 24.2.1.10.617
1kwrSG2Carbonic anhydrase 24.2.1.10.616
3dazMZMCarbonic anhydrase 24.2.1.10.615
1bn4AL9Carbonic anhydrase 24.2.1.10.613
1a42BZUCarbonic anhydrase 24.2.1.10.612
4kniE1ECarbonic anhydrase 24.2.1.10.612
3eft3BSCarbonic anhydrase 24.2.1.10.609
1cilETSCarbonic anhydrase 24.2.1.10.607
1ttm667Carbonic anhydrase 24.2.1.10.606
3k2fNKXCarbonic anhydrase 24.2.1.10.605
2eu3FF3Carbonic anhydrase 24.2.1.10.604
3sbiE90Carbonic anhydrase 24.2.1.10.604
3dbuD8WCarbonic anhydrase 24.2.1.10.597
3mhlJ71Carbonic anhydrase 24.2.1.10.596
1g1dFSBCarbonic anhydrase 24.2.1.10.595
1if4FBSCarbonic anhydrase 24.2.1.10.594
1bnwTPDCarbonic anhydrase 24.2.1.10.592
1zsbAZMCarbonic anhydrase 24.2.1.10.591
3ffpLC1Carbonic anhydrase 24.2.1.10.589
1kwqSG1Carbonic anhydrase 24.2.1.10.586
3n0nP9BCarbonic anhydrase 24.2.1.10.586
3po6DT9Carbonic anhydrase 24.2.1.10.585
4bf6X0QCarbonic anhydrase 24.2.1.10.584
2weoFBWCarbonic anhydrase 24.2.1.10.583
3t84SG6Carbonic anhydrase 24.2.1.10.583
1xpz4TZCarbonic anhydrase 24.2.1.10.578
3kigDA4Carbonic anhydrase 24.2.1.10.576
1bntAL2Carbonic anhydrase 24.2.1.10.574
3nb5R21Carbonic anhydrase 24.2.1.10.573
5fltVJJCarbonic anhydrase 24.2.1.10.572
1bnqAL4Carbonic anhydrase 24.2.1.10.570
1i9mINWCarbonic anhydrase 24.2.1.10.569
1g54FFBCarbonic anhydrase 24.2.1.10.566
1if8SBSCarbonic anhydrase 24.2.1.10.566
3f4xKLTCarbonic anhydrase 24.2.1.10.566
4itp1GDCarbonic anhydrase 24.2.1.10.566
3mdzEZLCarbonic anhydrase 74.2.1.10.564
1g4jFFBCarbonic anhydrase 24.2.1.10.563
3m2nJ74Carbonic anhydrase 24.2.1.10.562
4ilx1EZCarbonic anhydrase 24.2.1.10.561
3ni5C1HCarbonic anhydrase 24.2.1.10.557
4iwz1GOCarbonic anhydrase 24.2.1.10.557
2h4nAZMCarbonic anhydrase 24.2.1.10.556
3n4bWWZCarbonic anhydrase 24.2.1.10.556
3oysOYSCarbonic anhydrase 24.2.1.10.556
3b4fTUOCarbonic anhydrase 24.2.1.10.555
3mnaDWHCarbonic anhydrase 24.2.1.10.555
3t85SG7Carbonic anhydrase 24.2.1.10.555
2wejFB2Carbonic anhydrase 24.2.1.10.553
2wehFB1Carbonic anhydrase 24.2.1.10.552
4itoMPXCarbonic anhydrase 24.2.1.10.552
1g4oBSBCarbonic anhydrase 24.2.1.10.551
2x7uWZACarbonic anhydrase 24.2.1.10.549
3m2yBE0Carbonic anhydrase 24.2.1.10.549
3mzcS6ICarbonic anhydrase 24.2.1.10.549
1xq04TRCarbonic anhydrase 24.2.1.10.548
3m98E02Carbonic anhydrase 24.2.1.10.548
1cnwEG1Carbonic anhydrase 24.2.1.10.547
3m67E36Carbonic anhydrase 24.2.1.10.545
3dd82C7Carbonic anhydrase 24.2.1.10.544
4n16CHDCarbonic anhydrase 24.2.1.10.544
1i90INMCarbonic anhydrase 24.2.1.10.543
4k0tD9ZCarbonic anhydrase 24.2.1.10.543
4k13ETSCarbonic anhydrase 24.2.1.10.543
3zncBZ1Carbonic anhydrase 44.2.1.10.541
4kp8E1GCarbonic anhydrase 124.2.1.10.539
1oq5CELCarbonic anhydrase 24.2.1.10.538
3betCTFCarbonic anhydrase 24.2.1.10.538
3dccD9ZCarbonic anhydrase 24.2.1.10.537
1i9nIOACarbonic anhydrase 24.2.1.10.536
3oikWZBCarbonic anhydrase 24.2.1.10.536
1jd0AZMCarbonic anhydrase 124.2.1.10.535
3f7uAG4Carbonic anhydrase 44.2.1.10.534
3s9tE49Carbonic anhydrase 24.2.1.10.533
3d8wD8WCarbonic anhydrase 24.2.1.10.532
3mhoJ43Carbonic anhydrase 24.2.1.10.531
3igpDT7Carbonic anhydrase 24.2.1.10.530
3sbhE65Carbonic anhydrase 24.2.1.10.530
3ml2SU0Carbonic anhydrase 24.2.1.10.528
3saxE50Carbonic anhydrase 24.2.1.10.528
1bnuAL3Carbonic anhydrase 24.2.1.10.527
2powI7CCarbonic anhydrase 24.2.1.10.527
3f7bAG5Carbonic anhydrase 44.2.1.10.527
1bnmAL8Carbonic anhydrase 24.2.1.10.522
3mhcARZCarbonic anhydrase 24.2.1.10.522
4kp5E1FCarbonic anhydrase 124.2.1.10.522
1oklMNSCarbonic anhydrase 24.2.1.10.521
1ydaAZMCarbonic anhydrase 24.2.1.10.521
2wd2MS5Carbonic anhydrase 24.2.1.10.521
3s8xE59Carbonic anhydrase 24.2.1.10.519
4pxxCHDCarbonic anhydrase 24.2.1.10.519
3p5lIT5Carbonic anhydrase 24.2.1.10.518
4ht2V50Carbonic anhydrase 124.2.1.10.517
3n3jWWVCarbonic anhydrase 24.2.1.10.513
1i8zINLCarbonic anhydrase 24.2.1.10.512
1i9pIOECarbonic anhydrase 24.2.1.10.512
3n2pAYXCarbonic anhydrase 24.2.1.10.512
3oimVZ5Carbonic anhydrase 24.2.1.10.512
4x5sAZMCarbonic anhydrase (Carbonate dehydratase)/0.512
3fw3ETSCarbonic anhydrase 44.2.1.10.511
1bnvAL7Carbonic anhydrase 24.2.1.10.509
3dcwEZLCarbonic anhydrase 24.2.1.10.509
4bf19FKCarbonic anhydrase 24.2.1.10.505
2wegFBVCarbonic anhydrase 24.2.1.10.504
4knjE1FCarbonic anhydrase 24.2.1.10.502
3m96E38Carbonic anhydrase 24.2.1.10.501
1cnxEG2Carbonic anhydrase 24.2.1.10.500
3bl1BL1Carbonic anhydrase 24.2.1.10.500
3l14I7BCarbonic anhydrase 24.2.1.10.500
3v2jAZMCarbonic anhydrase 24.2.1.10.500
3mmfD9HCarbonic anhydrase 24.2.1.10.496
3dd0EZLCarbonic anhydrase 24.2.1.10.494
4uovAZMCarbonate dehydratase/0.493
3m40J45Carbonic anhydrase 24.2.1.10.492
4mo82VQCarbonic anhydrase 24.2.1.10.490
3lxeTORCarbonic anhydrase 14.2.1.10.488
3mhiJ90Carbonic anhydrase 24.2.1.10.487
1cnyEG3Carbonic anhydrase 24.2.1.10.481
3h3qH13Collagen type IV alpha-3-binding protein/0.479
1eouSMSCarbonic anhydrase 24.2.1.10.477
1okmSABCarbonic anhydrase 24.2.1.10.473
1oknSTBCarbonic anhydrase 24.2.1.10.472
4iae1DXAlr2278 protein/0.470
4lu3AZMCarbonic anhydrase 144.2.1.10.470
3oy0OY0Carbonic anhydrase 24.2.1.10.466
4xiwAZMCarbonic anhydrase, alpha type/0.463
3oyqOYQCarbonic anhydrase 24.2.1.10.459
1rj6AZMCarbonic anhydrase 144.2.1.10.456
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.455
3fr5I4AFatty acid-binding protein, adipocyte/0.455
4k0zMZMCarbonic anhydrase 24.2.1.10.454
4knmE1ECarbonic anhydrase 134.2.1.10.454
2rqfJH3Hemolymph juvenile hormone binding protein/0.453
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.452
3h3t16HCollagen type IV alpha-3-binding protein/0.452
3myqE27Carbonic anhydrase 24.2.1.10.451
4a802ANMajor pollen allergen Bet v 1-A/0.451
4jicFMNGTN Reductase/0.451
7stdCRPScytalone dehydratase4.2.1.940.451
4dz7D02Carbonic anhydrase 24.2.1.10.450
3p62FMNPentaerythritol tetranitrate reductase/0.449
4iah1DXAlr2278 protein/0.449
3h3r14HCollagen type IV alpha-3-binding protein/0.448
3zbsOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.448
1h50FMNPentaerythritol tetranitrate reductase/0.447
4kbyC2EStimulator of interferon genes protein/0.447
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.447
1h63FMNPentaerythritol tetranitrate reductase/0.444
1x1bSAHC-20 methyltransferase/0.443
4bfvZVVPantothenate kinase2.7.1.330.443
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
1o9bNAIQuinate/shikimate dehydrogenase/0.442
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.442
3hl0NADMaleylacetate reductase/0.441
1towCRZFatty acid-binding protein, adipocyte/0.440
4gdcNDPUDP-galactopyranose mutase/0.440