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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3ckxSTUSerine/threonine-protein kinase 242.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3ckxSTUSerine/threonine-protein kinase 242.7.11.11.000
4qmpDKISerine/threonine-protein kinase 242.7.11.10.558
2xikJ60Serine/threonine-protein kinase 252.7.11.10.522
4e4m0NHTyrosine-protein kinase JAK2/0.518
3t8oATPRhodopsin kinase/0.511
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.503
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.495
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.495
3zep1NXTyrosine-protein kinase JAK32.7.10.20.492
3ggfGVDSerine/threonine-protein kinase 26/0.487
4gmy0X5Tyrosine-protein kinase JAK2/0.484
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.482
4qmlANPSerine/threonine-protein kinase 242.7.11.10.481
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.480
3a7jADPSerine/threonine-protein kinase 242.7.11.10.480
3a7hATPSerine/threonine-protein kinase 242.7.11.10.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
3tnwF18Cyclin-dependent kinase 22.7.11.220.474
2hog710Serine/threonine-protein kinase Chk12.7.11.10.473
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.472
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.472
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.471
4dgo0JWCasein kinase II subunit alpha2.7.11.10.471
4hvh19RTyrosine-protein kinase JAK32.7.10.20.471
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.471
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.470
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4bbfO19Tyrosine-protein kinase JAK2/0.468
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.467
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.467
2pvnP63Casein kinase II subunit alpha2.7.11.10.466
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.465
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.465
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.465
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.464
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3uli1N3Cyclin-dependent kinase 22.7.11.220.464
4jia1K3Tyrosine-protein kinase JAK2/0.464
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.463
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.463
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.461
5auwQUEDeath-associated protein kinase 12.7.11.10.461
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.460
1yvj4STTyrosine-protein kinase JAK32.7.10.20.459
3be9P04Casein kinase II subunit alpha2.7.11.10.459
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.459
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.459
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.459
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.458
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.456
2j0j4STFocal adhesion kinase 12.7.10.20.456
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.456
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.455
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.455
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.454
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.454
4grb0XGCasein kinase II subunit alpha2.7.11.10.454
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.453
4fkw62KCyclin-dependent kinase 22.7.11.220.452
3zh8C58Protein kinase C iota type2.7.11.130.451
4hvg19QTyrosine-protein kinase JAK32.7.10.20.451
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.450
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.450
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.450
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.449
2wpa889Cyclin-dependent kinase 22.7.11.220.449
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4jqeANPCasein kinase II subunit alpha2.7.11.10.449
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.449
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.449
5drdATPAurora kinase A2.7.11.10.449
2x1nX1NCyclin-dependent kinase 22.7.11.220.448
4qmySTUSerine/threonine-protein kinase 242.7.11.10.448
2c6tDT5Cyclin-dependent kinase 22.7.11.220.447
2j0m4STFocal adhesion kinase 12.7.10.20.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.447
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.446
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.446
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.446
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.446
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.446
5auvAGIDeath-associated protein kinase 12.7.11.10.446
1fvv107Cyclin-dependent kinase 22.7.11.220.445
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.445
1oiyN41Cyclin-dependent kinase 22.7.11.220.444
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.444
4fx360KCyclin-dependent kinase 22.7.11.220.444
4qms1N1Serine/threonine-protein kinase 242.7.11.10.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
5av2KMPDeath-associated protein kinase 12.7.11.10.444
5dr9SKEAurora kinase A2.7.11.10.444
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.443
1wvxBD4Death-associated protein kinase 12.7.11.10.443
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.443
5av4GENDeath-associated protein kinase 12.7.11.10.443
1m2pHNACasein kinase II subunit alpha2.7.11.10.442
1oi9N20Cyclin-dependent kinase 22.7.11.220.442
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.442
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.442
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.442
3gubGUBDeath-associated protein kinase 12.7.11.10.441
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.441
5dt3ATPAurora kinase A2.7.11.10.441
1xjdSTUProtein kinase C theta type2.7.11.130.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.440
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.440
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.440
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
5auxKMPDeath-associated protein kinase 12.7.11.10.440