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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/1.000
1rkpIBMcGMP-specific 3',5'-cyclic phosphodiesterase/0.592
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.552
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.545
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.537
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.534
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.528
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.520
4ajm3A6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.519
4g2wNI0cGMP-specific 3',5'-cyclic phosphodiesterase/0.516
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.515
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.515
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.510
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.505
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.503
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.501
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.499
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.496
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.496
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.491
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.490
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.488
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.486
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.484
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.484
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.483
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.481
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.480
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.479
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.477
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.476
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.475
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.473
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.472
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.468
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.464
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.461
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.460
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.456
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.454
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.451
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
2fm0M98cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440