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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2pdp393Aldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2pdp393Aldose reductase1.1.1.211.000
1t41ID5Aldose reductase1.1.1.210.645
2fz9ZSTAldose reductase1.1.1.210.644
1t40ID5Aldose reductase1.1.1.210.640
2pdxZSTAldose reductase1.1.1.210.640
2dv0ZSTAldose reductase1.1.1.210.638
1z8962PAldose reductase1.1.1.210.636
2hv5ZSTAldose reductase1.1.1.210.633
4gca2X9Aldose reductase1.1.1.210.631
1z3n3NAAldose reductase1.1.1.210.630
2pzn393Aldose reductase1.1.1.210.628
2pdc393Aldose reductase1.1.1.210.627
3g5eQ74Aldose reductase1.1.1.210.627
3lenZSTAldose reductase1.1.1.210.618
3mb9ZSTAldose reductase1.1.1.210.618
2fz8ZSTAldose reductase1.1.1.210.617
2pd5ZSTAldose reductase1.1.1.210.617
2pdu393Aldose reductase1.1.1.210.612
2iki388Aldose reductase1.1.1.210.611
2qxwLDTAldose reductase1.1.1.210.609
2pdg47DAldose reductase1.1.1.210.607
3ghsLDTAldose reductase1.1.1.210.606
3ld5LDTAldose reductase1.1.1.210.604
3ghrLDTAldose reductase1.1.1.210.602
3t423T4Aldose reductase1.1.1.210.599
2duxZSTAldose reductase1.1.1.210.596
1pwlBFIAldose reductase1.1.1.210.595
1us0LDTAldose reductase1.1.1.210.595
2i16LDTAldose reductase1.1.1.210.593
3ghuLDTAldose reductase1.1.1.210.588
1ieiZESAldose reductase1.1.1.210.587
3ghtLDTAldose reductase1.1.1.210.587
2duzZSTAldose reductase1.1.1.210.586
2i17LDTAldose reductase1.1.1.210.583
2pdbZSTAldose reductase1.1.1.210.583
2hvoZSTAldose reductase1.1.1.210.581
2ikj393Aldose reductase1.1.1.210.577
1frbZSTAldose reductase-related protein 2/0.576
3m64393Aldose reductase1.1.1.210.576
3m4h388Aldose reductase1.1.1.210.575
4yu153NAldose reductase1.1.1.210.574
3m0iZSTAldose reductase1.1.1.210.573
2ikhLITAldose reductase1.1.1.210.572
3lboLDTAldose reductase1.1.1.210.568
3mc5393Aldose reductase1.1.1.210.559
3lqlLDTAldose reductase1.1.1.210.557
2pdfZSTAldose reductase1.1.1.210.553
2pdh47DAldose reductase1.1.1.210.553
2pdlTOLAldose reductase1.1.1.210.544
2fzdTOLAldose reductase1.1.1.210.540
3lz5LDTAldose reductase1.1.1.210.540
2pdn47DAldose reductase1.1.1.210.531
1zuaTOLAldo-keto reductase family 1 member B101.1.10.487
1ah3TOLAldose reductase1.1.1.210.484
2f2kTGGAldose reductase1.1.1.210.479
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.475
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.474
2pdyFIDAldose reductase1.1.1.210.474
4d2dALA_ALA_ALADi-or tripeptide:H+ symporter/0.473
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.471
2iqdLPAAldose reductase1.1.1.210.466
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
4dbw511Aldo-keto reductase family 1 member C3/0.466
5liu388Aldo-keto reductase family 1 member B101.1.10.465
2agtFIDAldose reductase1.1.1.210.464
4k4eK4ETankyrase-12.4.2.300.464
4wevSUZAldo-keto reductase family 1 member B101.1.10.464
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
4araC56Acetylcholinesterase3.1.1.70.460
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.459
3u2cSUZAldose reductase1.1.1.210.459
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.456
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.455
2inzOHPAldose reductase1.1.1.210.454
4i9z5BAcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
3rj0BLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
3e4vFMNUncharacterized protein/0.451
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
1m9nAMZBifunctional purine biosynthesis protein PURH2.1.2.30.450
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.450
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2pdwFIDAldose reductase1.1.1.210.450
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.449
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.449
4phlPILPhosphodiesterase/0.449
1o6qR17Squalene--hopene cyclase4.2.1.1290.448
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.447
2fzbTOLAldose reductase1.1.1.210.447
2w6cBM4Acetylcholinesterase3.1.1.70.447
1s1rNAPAldo-keto reductase family 1 member C3/0.446
2wzySQXSoluble acetylcholine receptor/0.446
4mm729JNa(+):neurotransmitter symporter (Snf family)/0.446
3sn6P0GBeta-2 adrenergic receptor/0.446
1ry0PG2Aldo-keto reductase family 1 member C3/0.445
2tplHPPTyrosine phenol-lyase4.1.99.20.445
4jtqNAPAldo-keto reductase family 1 member C2/0.445
2ohhFMNType A flavoprotein FprA10.444
4kn0MTXFolate receptor beta/0.444
1el3I84Aldose reductase1.1.1.210.443
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.443
3n0hTOPDihydrofolate reductase1.5.1.30.443
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.442
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.442
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.442
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4j7hTRHPCZA361.3/0.442
1s9dAFBCytohesin-2/0.441
1s9dAFBADP-ribosylation factor 1/0.441
2nvcITAAldose reductase1.1.1.210.441
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3f3y4OABile salt sulfotransferase2.8.2.140.441
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.441
4j7gTRHPCZA361.3/0.441
1dgbNDPCatalase1.11.1.60.440
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.440