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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1pjkANPCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1pjkANPCasein kinase II subunit alpha2.7.11.11.000
5cvfATPCasein kinase II subunit alpha2.7.11.10.602
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.567
3at4CCKCasein kinase II subunit alpha2.7.11.10.564
3axwTIDCasein kinase II subunit alpha2.7.11.10.557
4grb0XGCasein kinase II subunit alpha2.7.11.10.546
3q9xEMOCasein kinase II subunit alpha2.7.11.10.533
2pvmP29Casein kinase II subunit alpha2.7.11.10.509
2pvlP55Casein kinase II subunit alpha2.7.11.10.508
3u4uLNHCasein kinase II subunit alpha2.7.11.10.502
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.501
3be9P04Casein kinase II subunit alpha2.7.11.10.494
3pe2E1BCasein kinase II subunit alpha2.7.11.10.493
1m2pHNACasein kinase II subunit alpha2.7.11.10.487
4dgmAGICasein kinase II subunit alpha2.7.11.10.487
4dgnLU2Casein kinase II subunit alpha2.7.11.10.486
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.479
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.475
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.475
2pvhP19Casein kinase II subunit alpha2.7.11.10.471
2yaaATPDeath-associated protein kinase 2/0.469
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.468
4anmWULCasein kinase II subunit alpha2.7.11.10.468
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.466
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.465
4fv6E57Mitogen-activated protein kinase 12.7.11.240.465
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4aguD15Cyclin-dependent kinase-like 1/0.458
1om1IQACasein kinase II subunit alpha2.7.11.10.457
3bqr4RBDeath-associated protein kinase 3/0.456
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.453
4fv9E71Mitogen-activated protein kinase 12.7.11.240.453
5av3KMPDeath-associated protein kinase 12.7.11.10.453
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.452
5av2KMPDeath-associated protein kinase 12.7.11.10.452
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.451
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.449
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
4ji91M3Tyrosine-protein kinase JAK2/0.447
4ix6ADPUncharacterized protein/0.446
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.444
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.444
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.444
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.444
4ehzJAKTyrosine-protein kinase JAK1/0.443
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.443
4uyf73BBromodomain-containing protein 2/0.443
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.442
4jia1K3Tyrosine-protein kinase JAK2/0.442
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.441
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.441
3lltANPProtein serine/threonine kinase-1/0.440