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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1lp4ANPCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1lp4ANPCasein kinase II subunit alpha2.7.11.11.000
4dgo0JWCasein kinase II subunit alpha2.7.11.10.681
1dayGNPCasein kinase II subunit alpha2.7.11.10.672
4dgmAGICasein kinase II subunit alpha2.7.11.10.657
1dawANPCasein kinase II subunit alpha2.7.11.10.641
2pvnP63Casein kinase II subunit alpha2.7.11.10.627
4dgnLU2Casein kinase II subunit alpha2.7.11.10.619
4anmWULCasein kinase II subunit alpha2.7.11.10.612
3be9P04Casein kinase II subunit alpha2.7.11.10.602
2pvlP55Casein kinase II subunit alpha2.7.11.10.596
1m2qMNXCasein kinase II subunit alpha2.7.11.10.577
2pvhP19Casein kinase II subunit alpha2.7.11.10.574
5cvhADPCasein kinase II subunit alpha2.7.11.10.567
1m2pHNACasein kinase II subunit alpha2.7.11.10.560
4lfiGNPCasein kinase II subunit alpha2.7.11.10.553
3at3ATKCasein kinase II subunit alpha2.7.11.10.544
2pvjP44Casein kinase II subunit alpha2.7.11.10.542
4jr7GNPCasein kinase II subunit alpha2.7.11.10.525
4gub0Y4Casein kinase II subunit alpha2.7.11.10.522
3q9xEMOCasein kinase II subunit alpha2.7.11.10.516
3owk18ECasein kinase II subunit alpha2.7.11.10.513
4mwhATPCasein kinase II subunit alpha2.7.11.10.513
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.510
2pvkP45Casein kinase II subunit alpha2.7.11.10.509
4fi1ATPCasein kinase II subunit alpha2.7.11.10.509
3nszANPCasein kinase II subunit alpha2.7.11.10.507
4grb0XGCasein kinase II subunit alpha2.7.11.10.504
4jqeANPCasein kinase II subunit alpha2.7.11.10.499
2pvmP29Casein kinase II subunit alpha2.7.11.10.495
1om1IQACasein kinase II subunit alpha2.7.11.10.491
1m2rMNYCasein kinase II subunit alpha2.7.11.10.487
3u4uLNHCasein kinase II subunit alpha2.7.11.10.478
5cshATPCasein kinase II subunit alpha2.7.11.10.476
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.475
1e9hINRCyclin-dependent kinase 22.7.11.220.474
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.473
2x1nX1NCyclin-dependent kinase 22.7.11.220.467
2dwbANPAurora kinase A2.7.11.10.466
3at4CCKCasein kinase II subunit alpha2.7.11.10.465
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.464
1ol5ADPAurora kinase A2.7.11.10.462
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.461
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.461
3rmf20ZCyclin-dependent kinase 22.7.11.220.457
3q9zTXQCasein kinase II subunit alpha2.7.11.10.455
5dt3ATPAurora kinase A2.7.11.10.455
3pe2E1BCasein kinase II subunit alpha2.7.11.10.454
5dn3ATPAurora kinase A2.7.11.10.453
2b52D42Cyclin-dependent kinase 22.7.11.220.452
3qu0X40Cyclin-dependent kinase 22.7.11.220.452
5drdATPAurora kinase A2.7.11.10.452
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.451
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.451
1h1r6CPCyclin-dependent kinase 22.7.11.220.450
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.450
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.449
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.449
3rpv26ZCyclin-dependent kinase 22.7.11.220.448
2w17I19Cyclin-dependent kinase 22.7.11.220.446
1xjdSTUProtein kinase C theta type2.7.11.130.445
2bhhRYUCyclin-dependent kinase 22.7.11.220.445
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.445
3rak03ZCyclin-dependent kinase 22.7.11.220.445
3sqq99ZCyclin-dependent kinase 22.7.11.220.445
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.445
1g5sI17Cyclin-dependent kinase 22.7.11.220.444
4bcoT6QCyclin-dependent kinase 22.7.11.220.444
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.442
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.441
4hvi19STyrosine-protein kinase JAK32.7.10.20.441
5cu6ATPCasein kinase II subunit alpha2.7.11.10.441
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.440
3c50ADPRhodopsin kinase/0.440
3nga3NGCasein kinase II subunit alpha2.7.11.10.440
3ral04ZCyclin-dependent kinase 22.7.11.220.440
4b4oNDPEpimerase family protein SDR39U1/0.440
4bgg844Activin receptor type-12.7.11.300.440
4btjADPTau-tubulin kinase 12.7.11.10.440
4ix6ADPUncharacterized protein/0.440