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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1b2rFADFerredoxin--NADP reductase1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1b2rFADFerredoxin--NADP reductase1.18.1.21.000
1h85FADFerredoxin--NADP reductase1.18.1.20.852
1qgyFADFerredoxin--NADP reductase1.18.1.20.842
1go2FADFerredoxin--NADP reductase1.18.1.20.822
1qh0FADFerredoxin--NADP reductase1.18.1.20.794
1e64FADFerredoxin--NADP reductase1.18.1.20.727
1bjkFADFerredoxin--NADP reductase1.18.1.20.675
4c43FADFerredoxin--NADP reductase1.18.1.20.632
3zc3FADFerredoxin--NADP reductase1.18.1.20.604
2b5oFADFerredoxin--NADP reductase1.18.1.20.599
3zbtFADFerredoxin--NADP reductase1.18.1.20.599
4bprFADFerredoxin--NADP reductase1.18.1.20.582
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.581
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.577
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.576
1gjrFADFerredoxin--NADP reductase1.18.1.20.575
3w5uFADFerredoxin/0.575
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.569
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.567
1ewyFADFerredoxin--NADP reductase1.18.1.20.565
1w87FADFerredoxin--NADP reductase1.18.1.20.559
1e63FADFerredoxin--NADP reductase1.18.1.20.555
1sm4FADFerredoxin--NADP reductase/0.552
1qgzFADFerredoxin--NADP reductase1.18.1.20.545
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.545
3vo2FADFerredoxin--NADP reductase/0.545
1queFADFerredoxin--NADP reductase1.18.1.20.541
3qfsFADNADPH--cytochrome P450 reductase/0.534
1gawFADFerredoxin/0.532
1h42FADFerredoxin--NADP reductase1.18.1.20.530
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.529
2rc6FADFerredoxin--NADP reductase/0.528
1gaqFADFerredoxin/0.522
1e62FADFerredoxin--NADP reductase1.18.1.20.520
1gr1FADFerredoxin--NADP reductase1.18.1.20.515
1amoFADNADPH--cytochrome P450 reductase/0.514
2ok8FADFerredoxin--NADP reductase, apicoplast/0.512
3fpkFADFerredoxin-NADP reductase/0.511
1gvhFADFlavohemoprotein/0.509
1w35FADFerredoxin--NADP reductase1.18.1.20.508
1ja1FADNADPH--cytochrome P450 reductase/0.504
1ogjFADFerredoxin--NADP reductase1.18.1.20.504
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.492
3qftFADNADPH--cytochrome P450 reductase/0.492
1j9zFADNADPH--cytochrome P450 reductase/0.488
3ojxFADNADPH--cytochrome P450 reductase/0.479
4yaoFADNADPH--cytochrome P450 reductase/0.475
3otwCOAPhosphopantetheine adenylyltransferase/0.473
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.470
2vnjFADNADPH:ferredoxin reductase/0.468
1f20FADNitric oxide synthase, brain1.14.13.390.466
1fdrFADFerredoxin--NADP reductase1.18.1.20.466
5ah5LSSLeucine--tRNA ligase/0.465
3e6eDCSAlanine racemase/0.464
4j7gTRHPCZA361.3/0.464
1a8pFADFerredoxin--NADP reductase/0.463
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.463
2w6zL21Biotin carboxylase6.3.4.140.461
4j7hTRHPCZA361.3/0.461
4k1xFADNADPH:ferredoxin reductase/0.461
3e4vFMNUncharacterized protein/0.460
4fk8FADFerredoxin--NADP reductase/0.460
1ri1GTGmRNA cap guanine-N7 methyltransferase2.1.1.560.459
2ejzSAHDiphthine synthase/0.459
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.458
4ead0NPThymidine phosphorylase2.4.2.40.457
3qgi33FGenome polyprotein2.7.7.480.456
4n9qFMNFMN-dependent NADH-azoreductase 1/0.456
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.455
1u0wSTLChalcone synthase 22.3.1.740.454
3q9bB3NAcetylpolyamine amidohydrolase/0.453
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.451
1pr6XYAPurine nucleoside phosphorylase DeoD-type/0.451
1r58AO5Methionine aminopeptidase 2/0.451
4y0kNAPAntE/0.451
2rc5FADFerredoxin--NADP reductase/0.450
1cqxFADFlavohemoprotein/0.449
2bgiFADNADPH:ferredoxin reductase/0.449
3vt7VDXVitamin D3 receptor/0.448
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.447
3aezGDPPantothenate kinase2.7.1.330.447
3wqtANPCell division protein FtsA/0.447
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.447
2vnkFADNADPH:ferredoxin reductase/0.446
3fznD7KBenzoylformate decarboxylase4.1.1.70.446
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.446
1hzzNAPNAD(P) transhydrogenase subunit beta1.6.1.20.445
2hxzH7JCathepsin S3.4.22.270.445
4gm4TZDBenzoylformate decarboxylase4.1.1.70.445
2watCOAFatty acid synthase subunit alpha2.3.1.860.444
3eksCY9Actin-5C/0.444
3er93ATPoly(A) polymerase catalytic subunit2.7.7.190.444
4b65FADL-ornithine N(5)-monooxygenase/0.444
4bfxZVXPantothenate kinase2.7.1.330.444
2uuoLK3UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.443
2ylrFADPhenylacetone monooxygenase1.14.13.920.443
3rbaCODPhosphopantetheine adenylyltransferase/0.443
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.442
3kt8LTNTryptophan--tRNA ligase, cytoplasmic6.1.1.20.442
3p0fBAUUridine phosphorylase 22.4.2.30.442
4gg1TZDBenzoylformate decarboxylase4.1.1.70.442
1lkeDOGBilin-binding protein/0.441
3af1GDPPantothenate kinase2.7.1.330.441
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.441
5bt9NAP3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
2j2pSC2Ficolin-2/0.440
2wzySQXSoluble acetylcholine receptor/0.440
3qfcFADNADPH--cytochrome P450 reductase/0.440