scPDB - Distribution of Binding site Similarity values of 5ewk entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
5ewk	P34	Putative secreted protein

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
5ewk	P34	Putative secreted protein	/	1.000
1og4	NAI	T-cell ecto-ADP-ribosyltransferase 2	/	0.494
1og1	TAD	T-cell ecto-ADP-ribosyltransferase 2	/	0.491
3s5w	FAD	L-ornithine N(5)-monooxygenase	/	0.489
2get	COK	Pantothenate kinase	2.7.1.33	0.484
4uy6	SAH	Histidine N-alpha-methyltransferase	/	0.484
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.482
4wx2	F6F	Tryptophan synthase alpha chain	/	0.479
4wx2	F6F	Tryptophan synthase beta chain	4.2.1.20	0.479
2bn4	FMN	NADPH--cytochrome P450 reductase	/	0.470
1uae	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.467
2cle	F6F	Tryptophan synthase alpha chain	/	0.467
1cq7	PY5	Aspartate aminotransferase	2.6.1.1	0.466
4b2g	V1N	Uncharacterized protein	/	0.465
4bft	ZVT	Pantothenate kinase	2.7.1.33	0.464
2wsa	646	Glycylpeptide N-tetradecanoyltransferase	/	0.463
4bfx	ZVX	Pantothenate kinase	2.7.1.33	0.463
4e2y	JHZ	Methyltransferase	/	0.463
2clf	F6F	Tryptophan synthase alpha chain	/	0.460
1dgf	NDP	Catalase	1.11.1.6	0.457
1efy	BZC	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.457
1n5v	NOM	ActVA 6 protein	/	0.456
2g0n	GDP	Ras-related C3 botulinum toxin substrate 3	/	0.456
4b66	FAD	L-ornithine N(5)-monooxygenase	/	0.456
3br3	ET	HTH-type transcriptional regulator QacR	/	0.455
3uzw	NAP	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.455
4bzb	DGT	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.455
3arv	SAU	Chitinase A	/	0.454
3rtn	RTN	Beta-secretase 1	3.4.23.46	0.454
4b14	4XB	Glycylpeptide N-tetradecanoyltransferase	/	0.454
1cq8	PY6	Aspartate aminotransferase	2.6.1.1	0.453
1qs2	NAD	Vip2Ac	/	0.453
4jt9	1NS	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	3.5.1	0.453
2vcm	M11	Isopenicillin N synthase	1.21.3.1	0.452
1t4c	COA	Formyl-CoA:oxalate CoA-transferase	/	0.451
3n0h	TOP	Dihydrofolate reductase	1.5.1.3	0.451
4l32	1VF	Tankyrase-2	2.4.2.30	0.451
1tll	FMN	Nitric oxide synthase, brain	1.14.13.39	0.450
3e32	ED2	Protein farnesyltransferase subunit beta	2.5.1.58	0.450
3ksq	Z96	Protein farnesyltransferase subunit beta	2.5.1.58	0.450
4b64	FAD	L-ornithine N(5)-monooxygenase	/	0.450
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.450
1gjr	FAD	Ferredoxin--NADP reductase	1.18.1.2	0.449
1ry8	RUT	Aldo-keto reductase family 1 member C3	/	0.449
2zev	IPE	Geranylgeranyl pyrophosphate synthase	/	0.449
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.449
3irh	DTP	HD domain protein	/	0.449
4ba5	PXG	Probable aminotransferase	/	0.449
5bn3	ADP	V-type ATP synthase alpha chain	/	0.449
5bn3	ADP	NEQ263	/	0.449
5dp2	NAP	CurF	/	0.449
1ja1	FMN	NADPH--cytochrome P450 reductase	/	0.448
1kyv	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.448
1tco	FK5	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.448
1tco	FK5	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	3.1.3.16	0.448
2yac	937	Serine/threonine-protein kinase PLK1	2.7.11.21	0.448
3e7g	H4B	Nitric oxide synthase, inducible	1.14.13.39	0.448
2a1t	FAD	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.7	0.447
2c94	TSF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.447
2rc6	FAD	Ferredoxin--NADP reductase	/	0.447
4e32	DWN	Methyltransferase	/	0.447
3kr6	UD1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	/	0.446
4b1e	6T6	Beta-secretase 1	3.4.23.46	0.446
1g63	FMN	Epidermin decarboxylase	4.1.1	0.445
1g7u	PEP	2-dehydro-3-deoxyphosphooctonate aldolase	2.5.1.55	0.445
2yne	YNE	Glycylpeptide N-tetradecanoyltransferase	/	0.445
3tr0	5GP	Guanylate kinase	/	0.445
4a31	2CB	Glycylpeptide N-tetradecanoyltransferase	/	0.445
1ejb	INJ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.444
1i5r	HYC	Estradiol 17-beta-dehydrogenase 1	1.1.1.62	0.444
2xiq	5AD	Methylmalonyl-CoA mutase, mitochondrial	/	0.444
4j0v	1H7	Beta-secretase 1	3.4.23.46	0.444
4tnz	TTP	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.444
1pax	DHQ	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.443
1sm4	FAD	Ferredoxin--NADP reductase	/	0.443
2aou	CQA	Histamine N-methyltransferase	2.1.1.8	0.443
2rdn	1PL	1-deoxypentalenic acid 11-beta-hydroxylase	1.14.11.35	0.443
1w19	T1P	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.442
1w19	T4P	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.442
3bl7	DD1	m7GpppX diphosphatase	3.6.1.59	0.442
4bix	ADP	Sensor histidine kinase CpxA	/	0.442
4ge9	0L0	Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	2.6.1.39	0.442
4z61	ILE_THR_GLN_TYS_TYS	Phytosulfokine receptor 1	2.7.11.1	0.442
1icp	FMN	12-oxophytodienoate reductase 1	1.3.1.42	0.441
1til	ATP	Anti-sigma F factor	/	0.441
1yry	MSG	Purine nucleoside phosphorylase	2.4.2.1	0.441
2jh0	701	Prothrombin	3.4.21.5	0.441
3c49	KU8	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.441
3ihg	VAK	Aklavinone 12-hydroxylase RdmE	/	0.441
3l3l	L3L	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.441
3n14	FMN	Xenobiotic reductase	/	0.441
3zhv	TDW	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.441
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.441
1g9b	BAB	Botulinum neurotoxin type B	3.4.24.69	0.440
1x8l	OXR	Retinol dehydratase	/	0.440
2oeg	UPG	UDP-glucose pyrophosphorylase	/	0.440
3dr7	GPD	GDP-perosamine synthase	/	0.440
4dan	2FA	Purine nucleoside phosphorylase DeoD-type	2.4.2.1	0.440
4m2b	UPG	UDP-glucose pyrophosphorylase	/	0.440
4pnm	NU1	Tankyrase-2	2.4.2.30	0.440
4tvj	09L	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.440
4uth	FMN	Xenobiotic reductase	/	0.440
5bt9	NAP	3-oxoacyl-(Acyl-carrier-protein) reductase	/	0.440