sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 5c8y | ACP | Tubulin tyrosine ligase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 5c8y | ACP | Tubulin tyrosine ligase | / | 1.000 | |
| 5ca0 | ACP | Tubulin tyrosine ligase | / | 0.601 | |
| 5cb4 | ACP | Tubulin tyrosine ligase | / | 0.588 | |
| 4zhq | ACP | Tubulin tyrosine ligase | / | 0.555 | |
| 4zol | ACP | Tubulin tyrosine ligase | / | 0.515 | |
| 1e7v | LY2 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.483 | |
| 2chz | 093 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.478 | |
| 4o4i | ACP | Tubulin tyrosine ligase | / | 0.475 | |
| 4hvb | 19P | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.474 | |
| 5cwa | 0GA | Anthranilate synthase component 1 | 4.1.3.27 | 0.473 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.470 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.468 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.466 | |
| 4aw3 | MYV | Mycinamicin IV hydroxylase/epoxidase | / | 0.463 | |
| 5la6 | ACP | Tubulin tyrosine ligase | / | 0.463 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.462 | |
| 4anv | 751 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 4fhj | 0TZ | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.460 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.458 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.458 | |
| 2hma | SAM | tRNA-specific 2-thiouridylase MnmA | / | 0.457 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.457 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.456 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.456 | |
| 2q59 | 240 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 4e73 | 0NR | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.453 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.452 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.451 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.451 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.451 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.451 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.450 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.450 | |
| 4fhk | 0U0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4idv | 13V | Mitogen-activated protein kinase kinase kinase 14 | 2.7.11.25 | 0.450 | |
| 1iid | NHM | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.449 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4lxh | C1E | Alpha/beta hydrolase fold | / | 0.449 | |
| 4zj8 | SUV | Orexin receptor type 1 | / | 0.449 | |
| 2izr | BRK | Casein kinase I isoform gamma-3 | 2.7.11.1 | 0.448 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.447 | |
| 4awi | AQ2 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.447 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.447 | |
| 2i4j | DRJ | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3apf | BMW | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.445 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.445 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1zmd | NAI | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.445 | |
| 2y4g | TIR | TamL | / | 0.445 | |
| 3nd1 | SAH | Precorrin-6A synthase (Deacetylating) | / | 0.445 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.445 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 2bfy | H1N | Aurora kinase B-A | 2.7.11.1 | 0.444 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.444 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.444 | |
| 4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.443 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.443 | |
| 4gk2 | L66 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.443 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1l8q | ADP | Chromosomal replication initiator protein DnaA | / | 0.441 | |
| 3a4o | STU | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.441 | |
| 4lch | 1WN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.441 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.441 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1e8x | ATP | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.440 | |
| 2bl4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.440 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.440 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.440 | |
| 4aac | AAV | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.440 |