scPDB - Distribution of Binding site Similarity values of 5arl entry / Site 2

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
5arl	DCM	Ribonuclease 4	3.1.27

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
5arl	DCM	Ribonuclease 4	3.1.27	1.000
3zhs	TD6	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.490
2y60	M8F	Isopenicillin N synthase	1.21.3.1	0.485
4uug	PXG	Branched-chain amino acid aminotransferase, putative	/	0.480
2a58	RBF	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.475
2z7h	GG3	Geranylgeranyl pyrophosphate synthase	/	0.468
3r6i	JMS	Aldo-keto reductase family 1 member C3	/	0.465
1ni1	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.464
3zhv	TDW	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.463
4du6	GTP	GTP cyclohydrolase 1	/	0.463
1n95	HFP	Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha	/	0.461
1n95	HFP	Protein farnesyltransferase subunit beta	2.5.1.58	0.461
1ni1	2C5	Protein farnesyltransferase subunit beta	2.5.1.58	0.461
1w6r	GNT	Acetylcholinesterase	3.1.1.7	0.461
3zoi	M2W	Isopenicillin N synthase	1.21.3.1	0.459
1qti	GNT	Acetylcholinesterase	3.1.1.7	0.458
1s2c	FLF	Aldo-keto reductase family 1 member C3	/	0.458
1lb9	DNQ	Glutamate receptor 2	/	0.457
2vqq	TFG	Histone deacetylase 4	3.5.1.98	0.457
3phj	DHK	Shikimate dehydrogenase (NADP(+))	/	0.456
4hcy	0YN	Transketolase	/	0.456
1gtr	ATP	Glutamine--tRNA ligase	6.1.1.18	0.455
1qru	ATP	Glutamine--tRNA ligase	6.1.1.18	0.455
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.455
2jbs	FMN	p-hydroxyphenylacetate 3-hydroxylase, oxygenase component	/	0.454
3p0e	BAU	Uridine phosphorylase 2	2.4.2.3	0.454
2g8y	NAD	Hydroxycarboxylate dehydrogenase B	/	0.453
3n19	FNR	Xenobiotic reductase	/	0.453
3seq	NXX	Glutamine-dependent NAD(+) synthetase	6.3.5.1	0.453
3zhu	TD8	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.453
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.453
4h7c	10H	Aldo-keto reductase family 1 member C3	/	0.453
1h61	PDN	Pentaerythritol tetranitrate reductase	/	0.451
1obn	ASV	Isopenicillin N synthase	1.21.3.1	0.451
3sl2	ATP	Sensor histidine kinase WalK	/	0.450
4n3l	2FN	Prothrombin	3.4.21.5	0.450
1lnm	DTX	Bilin-binding protein	/	0.449
3g1r	FIT	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.449
3zbs	OVE	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.449
3zv7	NHG	Acetylcholinesterase	3.1.1.7	0.449
4a3u	FMN	NADH:flavin oxidoreductase/NADH oxidase	/	0.449
1n95	FTH	Protein farnesyltransferase subunit beta	2.5.1.58	0.448
1phq	FPE	2-dehydro-3-deoxyphosphooctonate aldolase	2.5.1.55	0.448
1tdu	DUR	Thymidylate synthase	/	0.448
2xf3	J01	Uncharacterized protein	/	0.448
3px3	T3Q	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	2.1.1.235	0.448
3zht	TD9	Multifunctional 2-oxoglutarate metabolism enzyme	1.2.4.2	0.448
1b87	ACO	Aac(6')-Ii protein	/	0.447
1x27	ASP_TYR_VAL_HIS_PTR	Tyrosine-protein kinase Lck	2.7.10.2	0.447
1h22	E10	Acetylcholinesterase	3.1.1.7	0.446
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.446
2e8u	IPE	Geranylgeranyl pyrophosphate synthase	/	0.446
2ges	COK	Pantothenate kinase	2.7.1.33	0.446
4ycp	FMN	tRNA-dihydrouridine(16) synthase	/	0.446
4z4p	SAH	Histone-lysine N-methyltransferase 2D	2.1.1.43	0.446
1i59	ANP	Chemotaxis protein CheA	2.7.13.3	0.445
2ed3	SAH	Diphthine synthase	/	0.445
2hxz	H7J	Cathepsin S	3.4.22.27	0.445
3muo	ZPR	Prolyl endopeptidase	/	0.445
1g9b	BAB	Botulinum neurotoxin type B	3.4.24.69	0.444
3e6e	DCS	Alanine racemase	/	0.444
3fl4	FL4	Mitogen-activated protein kinase 14	/	0.444
3g0y	P9A	3-oxoacyl-[acyl-carrier-protein] synthase 2	2.3.1.179	0.444
4b8w	NAP	GDP-L-fucose synthase	1.1.1.271	0.444
2a59	LMZ	6,7-dimethyl-8-ribityllumazine synthase	2.5.1.78	0.443
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.443
4ixd	1HV	Integrin alpha-L	/	0.443
1vot	HUP	Acetylcholinesterase	3.1.1.7	0.442
1xl8	152	Peroxisomal carnitine O-octanoyltransferase	2.3.1.137	0.442
2q7o	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.442
2v57	PRL	TetR family transcriptional regulator	/	0.442
4xbj	IN5	Alanine racemase, biosynthetic	/	0.442
1lke	DOG	Bilin-binding protein	/	0.441
3dy8	5GP	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
3euf	BAU	Uridine phosphorylase 1	/	0.441
3px2	T3Q	dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase	2.1.1.235	0.441
3zky	WT4	Isopenicillin N synthase	1.21.3.1	0.441
4kq6	DLZ	6,7-dimethyl-8-ribityllumazine synthase	/	0.441
5bt9	NAP	3-oxoacyl-(Acyl-carrier-protein) reductase	/	0.441
2iib	C5P	Alpha-2,3/2,6-sialyltransferase/sialidase	/	0.440
3cot	STR	3-oxo-5-beta-steroid 4-dehydrogenase	/	0.440
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.440