sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 1.000 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.724 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.716 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.707 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.696 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.690 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.686 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.673 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.664 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.663 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.659 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.655 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.654 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.648 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.647 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.643 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.641 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.635 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.633 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.630 | |
| 2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.629 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.628 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.624 | |
| 2pdk | SBI | Aldose reductase | 1.1.1.21 | 0.622 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.620 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.617 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.611 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.606 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.604 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.602 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.600 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.595 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.595 | |
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.595 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.592 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.588 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.586 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.583 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.581 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.581 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.577 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.576 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.574 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.573 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.570 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.567 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.554 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.553 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.545 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.544 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.543 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.530 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.520 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.517 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.514 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.512 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.507 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.497 | |
| 3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.485 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.482 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.481 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.481 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.476 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.476 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.473 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.473 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.472 | |
| 2ipj | FFA | Aldo-keto reductase family 1 member C2 | / | 0.471 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.471 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.470 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.468 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.463 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.461 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.461 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.460 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.460 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.460 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.460 | |
| 4gab | FID | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.460 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.458 | |
| 2vdy | HCY | Corticosteroid-binding globulin | / | 0.458 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.458 | |
| 4wev | SUZ | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.458 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.457 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.457 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.455 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.454 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.454 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.453 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.452 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.451 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3c1o | NAP | Eugenol synthase | / | 0.451 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.451 | |
| 4hcy | 0YN | Transketolase | / | 0.451 | |
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.451 | |
| 2inz | OHP | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.449 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 4kmz | FOL | Folate receptor beta | / | 0.447 | |
| 4phl | PIL | Phosphodiesterase | / | 0.447 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.446 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 4b2g | V1N | Uncharacterized protein | / | 0.446 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.446 | |
| 4gv4 | MEJ | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 1lke | DOG | Bilin-binding protein | / | 0.445 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.445 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.445 | |
| 1c7o | PPG | Hemolysin | / | 0.444 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.444 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.444 | |
| 3ele | PLP | Aminotransferase | / | 0.444 | |
| 3ojx | FMN | NADPH--cytochrome P450 reductase | / | 0.444 | |
| 3pkb | Y16 | Methionine aminopeptidase 2 | / | 0.444 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.443 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.443 | |
| 3gn7 | 3GN | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.442 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.442 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.442 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.442 | |
| 5ds3 | 09L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.441 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.441 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.440 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.440 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.440 |